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ABR-215757 (5757) is a quinoline-3-carboxamide (Q-compound) currently in clinical development for systemic sclerosis. Q-compounds have shown efficacy in several different models of autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis. However, the mechanism of action is still poorly understood. In this thesis we have tried to find the mechanism
There is increasing theoretical and empirical evidence that genetic compatibility among partners is an important determinant of fertilization success and offspring viability. In amphibians, females often actively choose partners from among a variety of males and polyandry is common. Genetic compatibility among partners may therefore be an important determinant of fertilization success and offsprin
Quantum dot (QD)-metal oxide composite forms a "heart" of the QD-sensitized solar cells. It maintains light absorption and electron-hole separation in the system and has been therefore extensively studied. The interest is largely driven by a vision of harvesting the hot carrier energy before it is lost via relaxation. Despite of importance of the process, very little is known about the carrier rel
A comprehensive bulk and surface investigation of high-quality In2O3(001) single crystals is reported. The transparent-yellow, cube-shaped single crystals were grown using the flux method. Inductively coupled plasma mass spectrometry (ICP-MS) reveals small residues of Pb, Mg, and Pt in the crystals. Four-point-probe measurements show a resistivity of 2.0 +/- 0.5 x 10(5) Omega cm, which translates
Streamlining new product development forces companies to make decisions on preliminary information. This article considers this challenge within the context of project management in the aerospace sector and, in particular, for the development of product-service systems. The concept of knowledge maturity is explored as a means to provide practical decision support, which increases decision makers’
Objective: To investigate test-retest reliability and internal consistency of a new instrument for evaluation of mobility device interventions. Material and methods: The instrument comprised 4 scales and one summed index. Two test-retest interviews involved 147 mobility device users (mean age 60 years) with a broad range of functional limitations, living at home. Results: For 2 scales and the summ
A number of methods for measuring moisture transport properties of cementitious materials were compared in a series of experiments. Two OPC mortars with two water-binder-ratios were wet cured for six months and used to produce specimens as discs with different thicknesses and diameters. The cup methods were easy to use, reliable and fairly rapid but need a stable, surrounding, CO2-free climate, ho
This article aims to expand our understanding of projectification in Swedish municipalities. Above all the article explores to what extent processes of projectification can be identified and if so how they unfold. The article draws its inspiration from critical management studies and uses the notion of sensemaking to identify the practices of projectification processes. Three processes of projecti
We describe further development of ballistic imaging adapted for the liquid core of an atomizing spray. To fully understand spray breakup dynamics, one must measure the velocity and acceleration vectors that describe the forces active in primary breakup. This information is inaccessible to most optical diagnostics, as the signal is occluded by strong scattering in the medium. Ballistic imaging mit
We predict that a single-level quantum dot without discernible splitting of its spin states develops a spin-precession resonance in charge transport when embedded into a spin valve. The resonance occurs in the generic situation of Coulomb blockaded transport with ferromagnetic leads whose polarizations deviate from perfect antiparallel alignment. The resonance appears when electrically tuning the
Hypofractionated conformal stereotactic radiotherapy (HCSRT) is an established method of treating brain lesions such as arteriovenous malformations (AVMs) and brain metastases. The aim of this study was to investigate the reliability of treatment plans in the terms of dose distribution and absorbed dose for HCSRT. Methods and materials. Treatment plans for three different clinical intracerebral ta
The aim of this study was to explore community perceptions about child sexual abuse in Tanzania. Thirteen focus group discussions were conducted with adult community members. The core category, children's rights challenged by lack of agency, was supported by eight categories. Aware but distressed portrayed feelings of hopelessness, lack of trust in the healthcare and legal systems reflected percei
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") and 2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) are hallucinogenic amphetamines with addictive properties. The hippocampus is involved in learning and memory and seems particularly vulnerable to amphetamine's neurotoxicity. We evaluated the neurotoxicity of DOI and MDMA in primary neuronal cultures of hippocampus obtained from Wistar ra
The development and functional cycle of the mammary gland involves a number of processes that are caricatured by breast cancer cells during invasion and metastasis. Expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been associated with metastatic, poor prognosis, and high-grade breast cancers. Since hypoxia affects normal epithelial differentiation, we hypothesise that
Recent experiments exposing migratory birds to altered magnetic fields simulating geographical displacements have shown that the geomagnetic field acts as an external cue affecting migratory fuelling behaviour. This is the first study investigating fuel deposition in relation to geomagnetic cues in long-distance migrants using the western passage of the Mediterranean region. Juvenile wheatears (Oe
The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W '), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 1.04 fb(-1). No excess above Standard Model expectations is observed. A W ' with S
III − V semiconductors have so far predom- inately been employed for n-type transistors in high-frequency applications. This development is based on the advantageous transport properties and the large variety of heterostructure combinations in the family of III − V semiconductors. In contrast, reports on p-type devices with high hole mobility suitable for complementary metal − oxide − semiconducto
The four-proton hole Pd-96 neighbor of the doubly-magic Sn-100 nucleus was studied in-beam, using a fusion-evaporation reaction of a Ni-58 beam on a Sc-45 target. States of Pd-96 were established up to an excitation energy of 9707 keV. A core-excited odd-parity isomer with T-1/2 = 37.7(1.1) ns was identified. Shell model calculations were performed in four different model spaces. Even-parity state
