Group A Streptococcus (GAS)causes infections ranging from mild sore throats to severe invasive disease; however, no licensed vaccine is currently available. In this thesis, the author leverages streptolysin O (SLO), an important GAS protein and therapeutic/vaccine target, as a model system to develop a multimodal protein mass spectrometry(MS) strategy. Through an integrated approach of MS-based pr

This paper suggests an approach to solving the time-of-arrival self-calibration problem for imbalanced problems, where there is a low number of receivers but many senders. The idea is to solve several subproblems created by only using data relating to four receivers. The solutions are then clustered according to a proposed metric in order to remove failed reconstructions. They are then combined in

As global climate change intensifies, the question of what makes a place habitable or uninhabitable is critical, particularly in the context of a potential future climate outside the realm of lived experience, and the possible concurrent redistribution of populations partly associated with such climatic shifts. The concept of habitability holds the potential for advancing the understanding of the

In this paper we propose minimal solvers for relative pose estimation for two views of the projected silhouettes of two 3D cylinders. Using such line features instead of the standard point feature correspondences means more stable information (i.e. more stable to lighting condition, seasons, changes in environment etc.). Such features also lead to more compact and semantically interpretable repres

Background: Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis. Methods: Study participants (n = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes. A coronary artery calcium score (CACS) > 0 defi

For effective mixing within microfluidic devices through the application of obstacle-based structures, a straightforward approach involves in-situ fabrication, such as the free-radical photopolymerization of hydrogel structures. However, oxygen inhibition presents a challenge for polydimethylsiloxane (PDMS)-based microfluidic chips. In this paper, we present a solution to the problem of hydrogel-s

Introduction: No national recommendation for antibiotic prophylaxis for planned caesarean section in Sweden exists. Swedish delivery units have chosen different strategies. Some units routinely administer antibiotic prophylaxis to all women for whom a caesarean section is planned, while other units give prophylactic antibiotics to risk groups only. We took advantage of this “natural experiment” to

Time delay estimation or Time-Difference-Of-Arrival estimates is a critical component for multiple localization applications such as multilateration, direction of arrival, and self-calibration. The task is to estimate the time difference between a signal arriving at two different sensors. For the audio sensor modality, most current systems are based on classical methods such as the Generalized Cro

Our food and land-use systems are critical for staying within our planetary boundaries and the Earth’s system resilience. Among the six Transformations required to achieve the Sustainable Development Goals (SDGs), the fourth Transformation—focusing on food, land, and water—is crucial. This Transformation is key to achieving SDG 2 (Zero Hunger), SDG 6 (Clean Water and Sanitation), SDG 12 (Responsib

The life of cutting tool inserts is critically important for efficient machining, reducing manufacturing cost, embedded energy, and enabling more complex parts to be machined. For these applications, cemented carbide (WC-Co) materials are a prime candidate. The performance of these materials can be limited by early fracture, typically via an intergranular fracture path with respect to carbide grai

Early studies on water - n-alkane - ionic surfactant microemulsions provide first hints for the possible existence of a foam-like nanostructure, i.e. a dense packing of polyhedral nanometer-sized water droplets separated by a thin layer of a continuous oil phase. Indeed, we found a foam-like structure in the system water/NaCl - hexyl methacrylate (C6MA) - dioctyl sulfosuccinate sodium salt (AOT).

In recent years, research interest in second language use and acquisition beyond the classroom has grown considerably. However, terminological confusion and definitional differences have made it difficult to compare findings and discover trends across studies, and more broadly synthesise new insights and developments. Therefore, this scoping review is intended to provide an overview of when, where

BACKGROUND: Lung transplantation remains hampered by a scarcity of viable donor lungs, partially attributed to donor lung injuries.METHODS: Three porcine lung injury models were studied: infection-induced using lipopolysaccharide (n = 7), aspiration-induced using endotracheal gastric content (n = 7), and injury using lavage and harmful ventilation (ventilator-induced lung injury; n = 7). Molecular

BACKGROUND AND PURPOSE: Adaptive radiotherapy (ART) involves treatment re-planning based on anatomical changes, which may improve target coverage and sparing of organs-at-risk (OARs). This study retrospectively assessed the technical feasibility and potential benefits of daily ART in combination with reduced planning target volume (PTV) margins for head and neck squamous cell carcinoma (HNSCC).MAT

Purpose: Obstructive sleep apnea (OSA) is a common disease in patients with coronary artery disease (CAD). Approximately 40–80% of cardiovascular disease patients have obstructive sleep apnea. The manifestation of it can vary significantly in different types of CAD patients. This systematic review and meta-analysis investigate the prevalence and severity of OSA in patients with acute coronary synd