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AIMS: Synthetic glucocorticoids, including dexamethasone (DEX), are clinically prescribed due to their immunoregulatory properties. In excess they can perturb glucose homeostasis, with individuals predisposed to glucose intolerance more sensitive to these negative effects. While DEX is known to negatively impact β-cell function, it is unclear how. Hence, our aim was to investigate the effect of DE

Most natural antisense RNAs display a high degree ofsecondary structure with stem-loops as their mostprominent feature. Mutations affecting the Inhibitoryactivity of these RNAs most often map in or close toloop regions in both the antisense and target RNAs.The primary recognition loops often contain 5- 7unpaired nucleotldes. Nucleotide changes in the loopsaffect the binding rate and, hence, the in

Our aim was to understand mechanisms for clustering and cross-linking of gliadins, a wheat seed storage protein type, monomeric in native state, but incorporated in network while processed. The mechanisms were studied utilizing spectroscopy and high-performance liquid chromatography on a gliadin-rich fraction, in vitro produced α-gliadins, and synthetic gliadin peptides, and by coarse-grained mode

Purpose: When healthy children/adolescents are potential stem cell donors to a sibling, ethical questions arise due to reduced autonomy and dependency on their family. This study aimed to explore the experiences of children/adolescents in Sweden who donated stem cells to a severely ill sibling. Method: Semi-structured interviews were conducted with thirteen donors, aged 6–17 years at the time of t

Low back pain is a leading cause of disability worldwide, putting a significant strain on individual sufferers, their families, and the economy as a whole. It has a significant economic impact on the global economy because of the costs associated with healthcare, lost productivity, activity limitation, and work absence. Self-management, education, and adopting healthy lifestyle behaviors, such as

Yiddish language, literature, and culture often deal with Jewish ritual and practice. This is seen in the structure and vocabulary of the language itself and also through a variety of literary styles. This chapter discusses examples from Yiddish language, literature and culture and shows how they each refer to Jewish rituals and practices.

Picosecond ultrasonics is a powerful tool for nanoscale metrology, giving access to dimensions and mechanical, thermal, and optical properties of nanomaterials. By monitoring the temporal evolution of the interaction of light with coherent acoustic phonons, also known as Brillouin oscillations, phonon lifetime and optical absorption can be measured. However, the extraction of these quantities can

We extract the heavy quark diffusion coefficient k and the resulting momentum broadening h p2i of a heavy quark embedded in a far-from-equilibrium gluon plasma using classical-statistical lattice simulations. We find several features in the time dependence of the momentum broadening: a short initial rapid growth of h p2i, followed by linear growth with time due to Langevin-type dynamics and damped

The auto-ignition caused by oblique shocks was investigated experimentally in a supersonic flow regime, with the incoming flow at a Mach number of 2.5. The transient characteristics of the auto-ignition caused by shock evolvements were recorded with a schlieren photography system, and the initial flame kernel generation and subsequent propagation were recorded using a high-speed camera. The fuel m

Understanding the mechanisms at the tool/chip interface during metal cutting is crucial in the production of almost every metallic component used in engineering applications. It is critical to have rapid, durable, and reliable machining processes. This work contributes to the understanding of mechanisms occurring on the tool in the secondary shear zone, and it is focusing on the tool side of the c

As climate change impacts unfold across the globe, growing attention is paid toward producing climate services that support adaptation decision-making. Academia, funding agencies, and decision-makers generally agree that stakeholder engagement in co-producing knowledge is key to ensure effective decision support. However, co-production processes remain challenging to evaluate, given their many int