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Mononuclear complexes and a coordination polymer of the 2-pyridylamino ((NHPy)-Py-2) functionalized P(V) ligand

Three mononuclear metal complexes, [{PO2((NHPy)-Py-2)(2)}(2)M] [Py-2 - 2-pyridyl; M - Zn (1), Ni (2), Co (3)], have been synthesized by reacting metal nitrates with tetrakis(2-pyridylamino)phosphonium chloride, [P((NHPy)-Py-2)(4)]Cl, under solvothermal reaction conditions. The ligand, [P((NHPy)-Py-2)(4)]Cl, is hydrolyzed in the reaction medium. All of the complexes are isostructural and show an oc

Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy

Dasatinib, a broad-spectrum tyrosine kinase inhibitor (TKI), predominantly targets BCR-ABL and SRC oncoproteins and also inhibits off-target kinases, which may result in unexpected drug responses. We identified 22 patients with marked lymphoproliferation in blood while on dasatinib therapy. Clonality and immunophenotype were analyzed and related clinical information was collected. An abrupt lympho

Defining Profiles of Functional Limitations in Groups of Older Persons: How and Why?

OBJECTIVE: Addressing the complexity of multiple health problems in the older population, the objective was to identify combinations of functional limitations for use in simulation analysis, to enable predictions of the potentially most severe person-environment fit (i.e., accessibility) problems among groups of older persons. METHOD: Utilizing data from 1,542 persons aged 75 to 89 years and apply

Amperometric In Vitro Monitoring of Penetration through Skin Membrane

The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharma

Thermo-mechanically coupled model of diffusionless phase transformation in austenitic steel

Abstract in UndeterminedA constitutive model of thermo-mechanically coupled finite strain plasticity considering martensitic phase transformation is presented. The model is formulated within a thermodynamic framework, giving a physically sound format where the thermodynamic mechanical and chemical forces that drive the phase transformation are conveniently identifiable. The phase fraction is treat

Analysis of In Situ Mechanical Properties of Phases in High-Alloyed White Iron Measured by Grid Nanoindentation

The paper presents an analysis of the in situ mechanical properties (e.g., hardness, elastic modulus, and volume fraction) of phases in high-alloy white iron measured by grid nanoindentation statistically, to reveal the contributions of individual phase properties to the global properties of the material. The in situ mechanical properties of phases measured by grid indentation were validated throu

Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins.

Here we report the first survey of galectin binding to glycoproteins of human serum. Serum was subjected to affinity chromatography using immobilized galectins, and the bound glycoproteins were analyzed by electrophoresis, Western blotting, and mass spectrometry. Galectins-3, -8 and -9 bound a much broader range of ligands in serum than previously known, galectin-1 bound less, and galectins-2, -4

Stadsbarndom: om barns erfarenheter av platser i staden

Artikeln presenterar två kvalitativa studier som fokuserat barns användning av och relation till platser utomhus utifrån barns perspektiv. Studierna genomfördes vid olika tidpunkter, i mitten av 1990-talet och under åren 2008–2009, med barn i ungefär samma åldrar (9–11 år), med liknande metoder och i snarlika typer av bostadsmiljöer, men i två olika svenska städer. Teoretiska utgångspunkter hämtas

Measurement of photon production in the very forward direction in deep-inelastic scattering at HERA

The production of photons at very small angles with respect to the proton beam direction is studied in deep-inelastic positron-proton scattering at HERA. The data are taken with the H1 detector in the years 2006 and 2007 and correspond to an integrated luminosity of 126 pb(-1). The analysis covers the range of negative four momentum transfer squared at the positron vertex 6 < Q(2) < 100 GeV2 and i

Targeting the voltage-gated calcium channels as treatment for type 2 diabetes

L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f

Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses

Objectives To determine the sensitivity and specificity of subjective evaluation of gray-scale and Doppler ultrasound findings (here called pattern recognition) when used by experienced ultrasound examiners with regard to making a specific diagnosis of adnexal masses. Methods Within the framework of a European multi-center study, the International Ovarian Tumor Analysis study, comprising nine ultr

Influence of End-Capping on the Self-Assembly of Model Amyloid Peptide Fragments

The influence of charge and aromatic stacking interactions on the self-assembly of a series of four model amyloid peptides has been examined. The four model peptides are based on the KLVFF motif from the amyloid beta peptide, A beta(16-20) extended at the N terminus with two P-alanine residues. We have studied NH2-beta A beta AKLVFF-COOH (FF), NH2-beta A beta AKLVF-COOH (F), CH3CONH-beta A beta AK