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EF-hand Ca2+-binding proteins participate in both modulation of Ca2+ signals and direct transduction of the ionic signal into downstream biochemical events. The range of biochemical. functions of these proteins is correlated with differences in the way in which they respond to the binding of Ca2+. The EF-hand domains of calbindin D-9k and calmodulin are homologous, yet they respond to the binding
High-spin terminating bands in heavy nuclei were first identified in nuclei around Er-158(90). While examples of terminating states have been identified in a number of erbium isotopes, almost nothing is known about the states lying beyond band termination. In the present work, the high-spin structure of Er-156,Er-157,Er-158 has been studied using the Gammasphere spectrometer. The subject of triaxi
Huntington’s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered
In this article the caring power in the Swedish probation service is discussed. By exploring the history of probation, formed since the early 19 th century, the structure that is constructed through human interaction and that defines the role of helper and helped is shown. Within this structure, different interpretations exist and different stories are told. This variation is highlighted through s
Core-level spectroscopy and valence-band photoelectron spectroscopy were used to study the Ge(100)2×1 surface dosed with 0.5–100 L H2O at 160 K. It is determined that H2O adsorbs molecularly at 160 K and forms ice. The H2O molecules dissociate into H and OH radicals on the Ge(100)2×1 surface when the sample is heated to 300 K. A simple adsorption model that accounts for the calculated H and OH cov
Problems related to the urogenital tract are common in elderly women. Control of micturition is often impeded and questionnaire-based studies have reported a prevalence of poor control of micturition in about 30% of postmenopausal women. In an ongoing cohort comprising women born between 1935 and 1945, an interim analysis was performed in 1800 women based on an interview and questionnaire. The pre
The objectives are to relate species distributions among 110 non-fertilized grassland ('dry meadow') sites in southeastern Sweden to soil chemical, physical, exposure and management variables using correlation, stepwise regression and factor (PCA) analysis based on quantitative data. It was suggested that soil acidity variables (pH, base saturation, exchangeable Ca, Al, Mn,and Fe), P, K, Mg, and N
Autoantibodies to insulin (IAA) are one of the first markers of the autoimmune process leading to type 1 diabetes (T1D). While other autoantibodies in T1D have been studied extensively, relatively little is known about IAA and their binding specificities, especially after insulin treatment is initiated. We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment d
Two hypotheses concerning cerebellar function and predictive behavior are the sensory prediction hypothesis and the timing hypothesis. The former postulates that the cerebellum is critical in generating expectancies regarding forthcoming sensory information. The latter postulates that this structure is critical in generating expectancies that are precisely timed; for example, the expected duration
Omega-3 fatty acids (omega-3 FA) are constituents of the membranes of all cells in the body and are precursors of locally produced hormones, eicosanoids, which are important in the prevention and treatment of various diseases, especially in women. Omega-3 FA are of interest in some of the most common conditions affecting women. One mechanism underlying dysmenorrhea is a disturbed balance between a
Objectives: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. Design and methods: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of
The outermost, singly ionized valence state of N-2, the X (2)Sigma(g)(+) state, is investigated in detail as a function of the photon frequency bandwidth for core excitation to the N 1s-->pi(*) resonance, where the photon frequency is tuned in between the first two vibrational levels of this bound intermediate electronic state. We find a strong, nontrivial dependence of the resulting resonant phot
Dysphagia is a common symptom from the oral cavity, pharynx and esophagus, and its causes may be morphological or functional. A biphasic barium swallow is the best way of evaluating these patients. Using a careful clinical history, and by tailoring the examination to the individual case, the radiologist is usually able to pinpoint the cause of the patient's complaints and suggest further diagnosti
Several hundred specimens of a tiny olenid trilobite, Ctenopyge ceciliae sp. nov., have been found in stinkstone nodules in the upper Cambrian Peltura scarabaeoides Zone in southern Sweden. This exceptionally spinose form is known only from disarticulated specimens, but is quite well preserved, and all growth stages are represented. The early ontogenetic stages are exceptionally small, the protasp
In 1782, Jon Petursson, a district physician in Northern Iceland, published a textbook on arthritis and its remedies intended for common use. Working within a very simple diagnostic system, essentially comprising osteoarthritis (arthritis h a ) and inflammatory arthritis (arthritis vaga), he describes arthritis vaga as a common, chronic, symmetric, destructive, inflammatory polyarthritis, sometime
