Purpose Radiation therapy is frequently used in treating different types of tumors, although associated with serious side effects, such as fibrosis and complicated diarrhea. This study was designed to define the adhesive mechanisms behind radiotherapy-induced leukocyte recruitment in the colon. Methods All mice, except control animals, were radiated with a single dose of 20 Gy. Mice were pretreate

BACKGROUND: Brain stem herniation due to raised intracranial pressure (ICP) is a common cause of mortality in severe bacterial meningitis, but continuous measurements of ICP and the effects of ICP-reducing therapy in these patients have, to our knowledge, not been described. METHODS: During a four-year period, an ICP-monitoring device was implanted in patients admitted to our hospital with severe

'Strategic research' has become a goal of government policy throughout the industrial world. This paper follows the emergence of new approaches to the funding of 'strategic research' in Sweden, by examining three research foundations created in the late 1990s, and considers their ambitions, limitations, and achievements.

A total of 10,474 unicompartmental knee arthroplasties was performed for medial osteoarthritis in Sweden between 1986 and 1995. We sought to establish whether the number of operations performed in an orthopaedic unit affected the incidence of revision. Three different implants were analysed: one with a high revision rate, known to have unfavourable mechanical and design properties; a prosthesis wh

Dragon is a word oriented stream cipher submitted to the ECRYPT project, it operates on key sizes of 128 and 256 bits. The original idea of the design is to use a nonlinear feedback shift register (NLFSR) and a linear part (counter), combined by a filter function to generate a new state of the NLFSR and produce the keystream. The internal state of the cipher is 1088 bits, i.e., any kinds of TMD at

The molecular mechanism whereby the small heat-shock protein ( sHsp) chaperones interact with and prevent aggregation of other proteins is not fully understood. We have characterized the sHsp-substrate protein interaction at normal and increased temperatures utilizing a model substrate protein, citrate synthase ( CS), widely used in chaperone assays, and a dodecameric plant sHsp, Hsp21, by chemica

Magnetically trapped atoms in Bose-Einstein condensates are spin polarized. Since the magnetic field is inhomogeneous, the atoms acquire Berry phases of the Aharonov-Bohm type during adiabatic motion. In the presence of an electric field, there is an additional Aharonov-Casher effect. Taking into account the limitations on the strength of the electric fields due to the polarizability of the atoms,

The fetal inflammatory response has been suggested as causal in neonatal morbidity. Serial levels of circulating cytokines were evaluated in 74 infants with a mean gestational age (GA) of 27.1 wk. Pro-inflammatory and modulatory (IL-4, IL-10) cytokines were analyzed from cord blood, and at 6, 24, and 72 h postnatal age. Measure of cytokine burden over time was assessed by calculating the area unde

The objective was to study the effects of ethanol on coagulation and fibrinolysis in whole blood. Blood samples from healthy volunteers were analyzed before and after in-vitro addition of ethanol in order to achieve ethanol concentrations of 0, 1, 2 and 4[per mille sign], respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. We

During biosynthesis of bacteriochlorophyll or chlorophyll, three protein subunits of 140, 70, and 42 kDa interact to insert Mg2+ into protoporphyrin IX. The semi-dominant Chlorina-125,-157, and -161 mutants in barley are deficient in this step and accumulate protoporphyrin IX after feeding on 5-aminolevulinate. Chlorina-125,-157, and -161 are allelic to the recessive xantha-h mutants and contain G

Forests cover about 56% of the land area in Sweden and forest damage due to strong winds has been a recurring problem. In this paper we analyse recorded storm damage in Swedish forests for the years 1965-2007. During the period 48 individual storm events with a total damage of 164 Mm(3) have been reported with the severe storm on 8 to 9 January 2005, as the worst with 70 Mm(3) damaged forest. For

The paper describes a novel method for self-tuning gross heat release computation in internal combustion engines suitable for both online usage in combustion phasing control applications and post-processing of cylinder pressure measurements. The method estimates the polytropic exponents and cylinder pressure offsets immediately preceding and succeeding the combustion event, respectively, using a f

PURPOSE: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design.METHOD: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up

[1] This paper takes a novel approach to a known basic difficulty with computer simulations of nonlinear dynamical systems relevant to climate modeling. Specifically, we show by minimal examples how small systematic modeling errors might survive averaging over an ensemble of initial conditions. The resulting predictive errors can grow slowly enough initially that they may be overlooked without con

AIM: To infect mice with atypical Campylobacter concisus (C concisus) for the first time. METHODS: Three separate experiments were conducted in order to screen the ability of five clinical C concisus isolates of intestinal origin and the ATCC 33237 type strain of oral origin to colonize and produce infection in immunocompetent BALB/cA mice. The majority of the BALB/cA mice were treated with cyclop

This paper proposes a simple residual-based panel CUSUM test of the null hypothesis of cointegration. The test has a limiting normal distribution that is free of nuisance parameters, it is robust to heteroskedasticity and it allows for mixtures of cointegrated and spurious alternatives. Our Monte Carlo results suggest that the test has small-size distortions and reasonable power. In our empirical