Design, Method Development, and Synthesis of Novel Galectin-9N Inhibitors
Introducing an N-sulfonylamidine substituent in galactose increased the selectivity for galectin-9N, a protein involved in functions of the immune system, and is believed to have roles in autoimmune diseases and cancer. In this work, a fast method for regioselective monoalkylation of galactose by microwave irradiation was developed, and eight potential galectin-9N inhibitors were synthesized. Mole