Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on targeted proteasomal degradation has been recently developed. The system is based on a destabilizing domain (DD) of the Escherichia coli dihydrofolate reductase (DHFR) that directs fused proteins to proteasomal destruction. Creating YFP prot

In this thesis, human behavior in rail tunnel fires is explored. Descriptive knowledge is presented related to the evacuation of passenger trains, and the subsequent tunnel evacuation to a safe location. More specifically, a theoretical framework that can aid the understanding of human behavior is identified, and its applicability to rail tunnels is demonstrated. In addition, new empirical data on

Expansion of tourism in the northern periphery regions provides innovative resources for an economic boost to many of the peripheral communities. The northern ecosystems are however extremely vulnerable. It is therefore of vital importance for such communities to plan the growth of tourism along sustainable lines in order to secure long-term economic benefit from tourism. Geographical Information

Background: In a holistic view of care, the family is important for the patient as well as for the staff and integration of family members in health care is a growing trend. Yet, family participation in the care is sparsely investigated and valid assessment instruments are needed. Setting: Data were collected from 200 family members participating in an intervention study at an emergency department

The NADPH oxidase 2 (NOX2) complex is a professional producer of reactive oxygen species (ROS) and is mainly expressed in phagocytes. While the activity of the NOX2 complex is essential for immunity against pathogens and protection against autoimmunity, its role in the development of malignant tumors remains unclear. We compared wild type and Ncf1 (m1J) mutated mice, which lack functional NOX2 com

International studies on the death of elderly nursing home residents show the complexity in the understanding of the professionals who care for the dying. The aim of this study is to explore the discourses about professional caregivers caring for those dying in Denmark in the last decade. A discourse analysis inspired by Foucault was constructed. The material consists of different source documents

This study investigates the lived experience of one transwoman, Claire, a public advocate and a manager with client services responsibilities. We examine Claire's story in order to discuss how situated contexts, such as different roles, locales and interactions, shape the way she experiences and perceives her trans body and gender identity. In particular, our analysis centres on how Claire's lived

Here we present unequivocal experimental proof that microscale cofactor- and membrane-less, direct electron transfer based enzymatic fuel cells do produce significant amounts of electrical energy in human lachrymal liquid (tears). 100μm diameter gold wires, covered with 17nm gold nanoparticles, were used to fashion three-dimensional nanostructured microelectrodes, which were biomodified with Coryn

In a recent paper Pedroni and Yao (2006) present strong evidence suggesting that Chinese provincial per-capita output is diverging, a result that goes against the Chinese government’s goal of a balanced wealth-creation across provinces. This paper provides an in-depth analysis of the reasoning behind this finding. Our main result is that the divergence does exist, even when new data and more advan

PURPOSE. To determine the temporal and spatial expression of Pitx2, a bicoid-like homeobox transcription factor, during postnatal development of mouse extraocular muscle and to evaluate its role in the growth and phenotypic maintenance of postnatal extraocular muscle. METHODS. Mouse extraocular muscles of different ages were examined for the expression of Pitx2 by RT-PCR, q-PCR, and immunostaining

In this letter we show that the use of slightly broadband laser sources like multimode alexandrite lasers for CH PLIF bears the danger of interferences from formaldehyde. Such interferences occur when the laser frequency is not carefully tuned to the B-X (0,0) R-branch band head at around 387.2 nm and manifest either in the appearance of an additional layer in the PLIF image or in a slight broaden

Popular Abstract in English The main aim of this thesis was to contribute to the knowledge about mechanisms involved in the development of type 1 diabetes (T1D) and other autoimmune diseases in children. Immune markers in relation to genetic propensity in children with autoimmune disease, mainly T1D and a small group of juvenile idiopathic arthritis (JIA) and thyroiditis (THYR), as well as healthyThe main aim of this thesis was to contribute to the knowledge about mechanisms involved in the development of type 1 diabetes (T1D) and other autoimmune diseases in children. Immune markers in relation to genetic propensity in children with autoimmune disease, mainly T1D and a small group of juvenile idiopathic arthritis (JIA) and thyroiditis (THYR), as well as healthy controls have been studied.

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, the building blocks for DNA synthesis, and are found in all but a few organisms. RNRs use radical chemistry to catalyze the reduction reaction. Despite RNR having evolved several mechanisms for generation of different kinds of essential radicals across a large evolutionary time frame, this initial r

Correlations induced by quantum statistics are sensitive to the spatiotemporal extent as well as dynamics of particle-emitting sources in heavy-ion collisions. In addition, such correlations can be used to search for the presence of a coherent component of pion production. Two- and three-pion correlations of same and mixed charge are measured at low relative momentum to estimate the coherent fract

Many animal taxa have been shown to possess the ability of true navigation. In this study we investigated the possibilities for geomagnetic bi-coordinate map navigation in different regions of the earth by analysing angular differences between isolines of geomagnetic total intensity and inclination. In no-grid zones where isolines were running almost parallel, efficient geomagnetic bi-coordinate n

In this thesis some research questions regarding durability and quality of roads has been investigated. The questions are analyzed from an image analysis point of view and aims to be a complement to existing methods for analyzing asphalt. One important factor for the durability of the asphalt layer on roads is the affinity between the stones in the asphalt and the binder that holds the stones tog

This thesis deals with motion in language and non-linguistic experience, distinguishing between actual motion (AM) and non-actual motion (NAM). AM is the experience of continuous change in an object’s position, expressed in sentences such as 'The man runs through the forest' and 'The woman is walking'. NAM refers to dynamic qualities involved in conceiving or perceiving static situations and is ex