Search results

Filter

Filetype

Your search for "*" yielded 528642 hits

A societal history of potato knowledge in Sweden c. 1650–1800

This article concerns the societal history of potato knowledge in early modern Sweden. Focusing on the communication process, it analyses when, how, why, and which type of knowledge of the potato was communicated and ultimately experienced a societal breakthrough in early modern Sweden. The article shows that knowledge of the potato was transformed as it crossed social, spatial, and media boundari

Persons and Genes. Is a Gene-Centered Evolutionary Psychology Compatible with a Person-Oriented Approach to Psychological Science?

According to Zagaria et al. (2020), evolutionary psychology may be the meta-theory that is needed if psychological science is to enter a paradigmatic stage. Other writers have suggested that what is needed is a person-oriented approach, which focuses on the person as a complex system that needs to be studied (1) as a whole (holism), (2) as an intentional agent in interaction with its environment (

Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

Increased plasma concentrations of lipoprotein(a) (Lp(a)) are associated with an increased risk for cardiovascular disease. Lp(a) is composed of apolipoprotein(a) (apo(a)) covalently bound to apolipoprotein B of low-density lipoprotein (LDL). Many of apo(a)'s potential pathological properties, such as inhibition of plasmin generation, have been attributed to its main structural domains, the kringl

Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX

Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX-inhibitor complexes using X-ray and neutron crystallography, a CA IX surface variant (CA IXSV; the catalytic domain with six surface amin

A crowdsourced set of curated structural variants for the human genome

A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is more challenging. In this study, we manually curated 1235 SVs, which can ultimately be used to evaluate SV callers or train machine learning models. We deve

Hilpinen's Theory of Inquiry

Risto Hilpinen’s name is associated with seminal contributions to many areas of analytic philosophy, including influential work on deontic logic and the theory of artifacts, as well as important early investigations into inductive logic and indefeasibility analyses of knowledge. A somewhat lesser known body of Hilpinen’s work concerns the theory of inquiry, whereby the central questions are how to

Search for multiple myeloma risk factors using Mendelian randomization

The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS

Network Importance Measures for Multi-Component Disruptions

The identification of important components with the potential for the most disruption is vital in network planning and analysis. Critical infrastructure systems are vulnerable to a variety of failures, whether natural (e.g., space weather, earthquakes) or intentional (e.g., malevolent acts). These systems are increasingly interconnected, which increases the risk of the propagation of disruptions.

Changes in precipitation extremes over the source region of the Yellow River and its relationship with teleconnection patterns

Precipitation extremes and their underlying causes are important processes to understand to plan appropriate adaptation measures. This paper presents an analysis of the spatiotemporal variability and trend of precipitation extremes in the important source region of the Yellow River and explores the connection to global teleconnection patterns and the 850-mb vector wind. Six indices for precipitati

The continent-ocean (Seve-Köli) boundary in the Sarek-Padjelanta Mts. revisited : Swedish Caledonides

In the Swedish Caledonides, the continent-ocean boundary is represented by the basal thrust of the Iapetus-derived Köli Nappe Complex (KNC) which overlies the Seve Nappe Complex (SNC) derived from the outer rifted margin of Baltica and the continent-ocean transition (COT). Current maps and literature subdivide the Seve teconostratigraphy in northern Sweden (Sarek-Padjelanta region) into three mega

Assessing environmental barriers by means of the swedish craig hospital inventory of environmental factors among people post-stroke

Background: When occupational therapists address environmental barriers to occupational engagement, some barriers might not be possible to reduce for single individuals, because decisions have to be taken at community or societal level, for example changes in public transport. Investigating environmental barriers by means of the Swedish Craig Hospital Inventory of Environmental Factors (CHIEF-S) m

Evaluation of digital breast tomosynthesis systems

In this study, two digital breast tomosynthesis (DBT) systems were evaluated: Siemens Mammomat Inspiration TOMO (Siemens Healthineers, Erlangen, Germany) and GE Senographe Pristina (GE, Buc, France). Along with differences such as angular range and detectors type, the systems use different reconstruction algorithms. One was available for the GE system, based on iterative reconstruction (IR). Two a

The Use of Complementary and Alternative Medicine (CAM) in Psychiatric Units in Sweden

Mental ill-health has been termed the pandemic of the 21st century, and a large share of those exposed do not receive treatment. Many people with depression, anxiety and other mental health problems consult complementary or alternative medicine (CAM), and CAM is used in conventional psychiatric care, in Sweden and in other countries. However, the extent to which CAM is used in psychiatric care, an

His Bundle and Left Bundle Pacing in Pediatrics and Congenital Heart Disease : A Single Center Experience

Long-term right ventricular pacing is associated with left ventricular dysfunction and cardiomyopathy, particularly in pediatric patients and those with congenital heart disease (CHD). Research has shown that pacing-induced cardiomyopathy can be reversed with nonselective or selective His bundle pacing in adults, however, the information available about the use of this type of therapy in pediatric

Longitudinal study of cognitive function in glioma patients treated with modern radiotherapy techniques and standard chemotherapy

Introduction: Cognitive function is an important outcome measure in patients with brain tumor, providing information about the patient’s clinical situation, treatment effects and possible progressive disease. The aim of this longitudinal study was to evaluate effects of the currently used radiation and chemotherapy treatment on cognitive function and to investigate associations between cognitive f

Elderly individuals with diabetes and foot ulcer have a probability for healing despite extensive comorbidity and dependency

Background: Limited scientific evidence for prevention and treatment of diabetic foot ulcers in elderly with comorbidities. Aim: To explore patient-related factors and outcomes in patients ≥75 years with diabetes and a foot ulcer. Method: Sub-analysis of consecutively presenting patients ≥75 years (N = 1008) from a previous study on 2,480 patients with diabetic foot ulcer treated in a multidiscipl