Resistance to the HER-2 targeting drug trastuzumab can be observed clinically, but the lack of suitable experimental models hampers studies of resistance mechanisms. We characterized a HER-2–positive carcinoma cell line (JIMT-1) derived from a 62-year-old breast cancer patient which was clinically resistant to trastuzumab. Multicolor fluorescence in situ hybridization revealed a complex hyperdiplo

A study on a possible solar wind interaction with the North AtlanticOscillation (NAO) is performed. Results are presented suggesting arelationship between the NAO index and the electric field strength E ofthe solar wind. A possible scenario for the suggested interaction isthat an electromagnetic disturbance is generated by the solar wind inthe global electric circuit of the ionosphere. This distur

PURPOSE: Adenosine triphosphate (ATP) (Sigma Chemical Co., St. Louis, Missouri) is known to contract animal as well as human detrusor muscle and recent investigations have shown an involvement of ligand gated purinergic-1 receptors in detrusor contraction. In addition, ligand gated purinergic-3 receptors have been demonstrated on suburothelial sensory nerves (C-fibers) and may be involved in diste

AIM: To study the cellular transport of L68Q cystatin C, the cystatin variant causing amyloidosis and brain haemorrhage in patients suffering from hereditary cystatin C amyloid angiopathy (HCCAA). METHODS: Expression vectors for wild-type and L68Q cystatin C were constructed and used to transfect mouse NIH/3T3 cells. Stable cell clones were isolated after cotransfection with pSV2neo. Clones expres

This article is an overview, introducing the currently used supercritical carbon dioxide (scCO2) based technology in association to biotechnological applications. Within each application, the basic principles of the technique, a description of the instrumentation, methodology, and problems encountered, and advantages over the traditional methods are discussed. The areas covered in this paper inclu

Background: In 1992, there were major changes in Swedish law of the deceased, which had led to a dramatic decrease in autopsy rates. The aim of this study was to investigate the prevalence of fatal or potential fatal surgical diseases within a Swedish forensic autopsy cohort, before and after this change in legislation. Methods: Deaths referred for forensic autopsy at the Institution of Forensic M

Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypothese

This study concerns whether the personality of drug addicts is related to their drug of choice. A group of 112 heavy drug addicts participated, each selected for either heroin (29 women, 52 men) or amphetamine (31 men) being their basic drug. Their personality was assessed by means of two percept-genetic techniques, the Spiral Aftereffect Technique (SAT) and the Defense Mechanism Technique modifie

Popular Abstract in Swedish Kavitation uppstår när trycket är så lågt så att vätska övergår till gas och det är ett problem i många vattenkraftverk på grund av att det kan försämra turbinverkingsgraden samt skada närliggande fasta ytor. Denna avhandling behandlar de numeriska svårigheter som man måste komma tillrätta med för att kunna datorsimulera kavitation i vattenturbiner. Dessa beror på den tCavitation is a problem in many hydroelectric power plants since it can cause adverse effects on performance and damage to nearby solid surfaces. The concerns of this thesis are the numerical aspects of flow simulations in cavitating hydraulic turbines which contain several difficulties: turbulent and complex flows, steady and moving parts of the geometry, bubble transport and cavitation developme

Paper wrappers and paper bindings have been used to preserve written and archival documents of all kinds. In the manuscript collection of Ericsberg (National Archives, Sweden) we find many examples of how written material was gathered and protected by simple paper bindings. Paper bindings are used as sketchbooks, for writing and calculating, as diaries, and as notebooks of administrative and econo

This thesis critically examines the world of NGOs in contemporary Nicaragua, and suggests connections between the current development 'boom' and the emergence of a materially privileged local development elite, which by means of its cultural and economic capital are in a position to exiercise considerable power in relation to other less powerful strata of the population. It is based on fieldwork c

Sugar beet (Beta vulgaris L.) plants injected with Cercospora beticola Sacc. as well as non-infected plants were grown under visible light with or without ultraviolet-B (UV-B, 280-320 nm) radiation for 40 days. An interaction between UV-B radiation and Cercospora leaf spot disease was observed, resulting in a large reduction in leaf chlorophyll content, dry weight of leaf laminae, petioles and sto

This study describes the removal of polycyclic aromatic hydrocarbons (PAHs) from creosote oil contaminated soil by modified Fenton's reaction in laboratory-scale column experiments and subsequent aerobic biodegradation of PAHs by indigenous bacteria during incubation of the soil. The effect of hydrogen peroxide addition for 4 and 10 days and saturation of soil with H2O2 on was studied. In both exp