Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large-scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions

The aim of this study was to investigate the global DNA-binding pattern of Wilms' tumor gene 1 (WT1) in leukemic cells. Clinical and preclinical data indicate the zinc finger transcription factor WT1 as an oncogene, but the full target gene repertoire of WT1 in leukemic cells has not been previously characterized. The -KTS isoforms (excluding the three amino acid (KTS) insert between zinc finger t

The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS

Background: Prognostic factors in patients with localized primary cutaneous malignant melanoma (CMM) are well described. However, prognostic factors for recurrence are less documented. Objectives: The aim of this study was to identify prognostic risk factors for first recurrence in patients with localized stages I-II CMM using population-based data. Methods: This study included 1437 CMM patients r

What is the role of arthroscopic surgery in degenerative knee disease? An expert panel produced these recommendations based on a linked systematic review triggered by a randomised trial published in The BMJ in June 2016, which found that, among patients with a degenerative medial meniscus tear, knee arthroscopy was no better than exercise therapy. The panel make a strong recommendation against art

A novel sparse coding framework with unity range codes and the possibility to produce a discriminative dictionary is presented. The framework is, in contrast to many other works, able to handle unsupervised, supervised and semi-supervised settings. Furthermore, codes are constrained to be in unity range, which is beneficial in many scenarios. The paper presents the framework and solvers used to pr

This paper provides regional GDP estimates for the 24 Swedish regions (NUTS-3) for the benchmark year 1571 and for 11 ten-year benchmarks for the period 1750-1850. The 1571 estimates are based on tax sources and agricultural statistics. The 1750-1850 estimates are produced following the widely used methodology by Geary and Stark (2002): labour force figures from population censuses at regional lev

This article analyses new waves of cultural production in the late Soviet and post-Soviet period. It focuses on contemporary artists’ self-perception and self-positioning in the new realities of the postsocialist cultural realm and national awakening discourses. Independent contemporary artists of the post-Soviet period form new artistic movements, such as Punk Shamanism in Kazakhstan, to produce

Despite of having no explicit shape model, multi-atlas approaches to image segmentation have proved to be a top-performer for several diverse datasets and imaging modalities. In this paper, we show how one can directly incorporate shape regularization into the multi-atlas framework. Unlike traditional methods, our proposed approach does not rely on label fusion on the voxel level. Instead, each re

A method using optimal control results as input to operator assist systems, automatic functions and autonomous construction machine control is presented. This method complements the vast research within autonomy to achieve the most fuel efficient solution from results that are already available from concept evaluation and system optimization in early development. The optimal control results are va

Detailed mechanisms behind regeneration after nerve injury, in particular signal transduction and the fate of Schwann cells (SCs), are poorly understood. Here, we investigated axotomy-induced activation of extracellular- signal-regulated kinase-1/2 (ERK1/2; important for proliferation) and m-calpain in vitro, and the relation to Ca2+ deletion and Schwann cell proliferation and death after rat scia

DEBATT. Virusattacken Wannacry visar att sårbarheten i våra digitala system kan öka när myndigheter bedriver hemlig dataavläsning, skriver Stefan Larsson, docent Lunds universitet.

This volume is one of the outcomes of the network project In Search for Transnational Memory in Europe (ISTME), which was financed during four years 2012-2016 by a grant from COST (European Cooperation in Science and Technology) as COST Action IS1203. The Centre for European Studies (CFE) at Lund University was grant holder for ISTME, and the Centre’s Head Prof. Barbara Törnquist-Plewa was chair.