Total levels of circulating prostate-specific antigen (tPSA) are strongly associated with prostate cancer (PCa) risk and outcome but benign prostate disease is the most frequent cause of a moderately elevated PSA level. Free PSA (fPSA) forms are independently associated with PCa risk and contribute modest diagnostic enhancements above and beyond tPSA alone. We developed an immunoassay for fPSA sub

Popular Abstract in Swedish HIV är en av de dödligaste farsoterna i världen och 30-40 miljoner människor beräknas ha dött AIDS. Genom att konstant förändra sig ligger viruset hela tiden ett steg före immunförsvaret, och immunförsvaret klarar därför inte av att bekämpa infektionen. HIV skiljer sig också från andra virus genom att det drabbar och långsamt utplånar immunförsvaret. Det gör att HIV kanThe two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. The V1-V3 region of the HIV-1 env gp120 is important for HIV-1 corecept

The formation of nanoscale amyloid fibrils from normally soluble peptides and proteins is a common form of self-assembly phenomenon that has fundamental connections with biological functions and human diseases. The kinetics of this process has been widely studied and exhibits on a macroscopic level three characteristic stages: a lag phase, a growth phase and a final plateau regime. The question of

Lake water level forecasting is very important for an accurate and reliable management of local and regional water resources. In the present study two nonlinear approaches, namely phase-space reconstruction and self-exciting threshold autoregressive model (SETAR) were compared for lake water level forecasting. The modeling approaches were applied to high-quality lake water level time series of the

We assessed age-related differences in adults in familiarization to treadmill walking within virtual environments (VE), and examined whether treadmill walking after familiarization resembles overground walking. Seventeen younger and 17 older adults walked at preferred speed on an overground walkway and afterwards walked at the same speed for 20 min on a treadmill coupled to a VE. A motion capture

Orthognathic surgery is a frequent procedure at Swedish Oral and Maxillofacial Surgery Departments.The number of clinical and radiographic postoperative follow-up examinations and the choice of radiographic methods seem to vary.The intention with this study was to find out when postoperative clinical and radiographic follow-up was performed following orthognathic surgery and the type of radiograph

We review the observational evidence for extra mixing in stars on the red giant branch (RGB) and discuss why thermohaline mixing is a strong candidate mechanism. We recall the simple phenomenological description of thermohaline mixing and aspects of mixing in stars in general. We use observations of M3 to constrain the form of the thermohaline diffusion coefficient and any associated free paramete

Semiconductor billiards are often considered as ideal systems for studying dynamical chaos in the quantum mechanical limit. In the traditional picture, once the electron's mean free path, as determined by the mobility, becomes larger than the device, disorder is negligible and electron trajectories are shaped by specular reflection from the billiard walls alone. Experimental insight into the elect

Huntington's disease (HD) is caused by an expanded polyglutamine tract in the protein huntingtin (htt). Although HD has historically been viewed as a brain-specific disease, htt is expressed ubiquitously, and recent studies indicate that mutant htt might cause changes to the immune system that could contribute to pathogenesis. Monocytes from HD patients and mouse models are hyperactive in response

The origin of the new kinematically identified metal-poor stellar stream, the KFR08 stream, has not been established to date. We present stellar parameters, stellar ages, and detailed elemental abundances for Na, Mg, Al, Si, Ca, Sc, Ti, Cr, Ni, Zn, Sr, Y, Zr, Ba, La, and Eu for 16 KFR08 stream members based on an analysis of high-resolution spectra. Based on the abundance ratios of 14 elements, we

The structure and chemical composition of Pd nanoparticles exposed to pure CO and mixtures of CO and O-2 at elevated temperatures have been studied in situ by a combination of X-ray Diffraction and X-ray Photoelectron Spectroscopy in pressures ranging from ultra high vacuum to 10 mbar and from room temperature to a few hundred degrees celsius. Our investigation shows that under CO exposure, above

Impaired autonomic control of postural homeostasis results in orthostatic intolerance. However, the role of neurohormones in orthostatic intolerance has not been explained.

The early Holocene and the development of sedentary, agriculturally based life allowed for an unprecedented accumulation of material goods (Bogucki 2011; Scarre 2005:191). This affected the organization and objectives of lithic technologies. In contrast to mobile hunter-gathers, who mainly developed elaborate technologies in response to risk (Collard et al 2013, Torrence 2001) Neolithic societies

Popular Abstract in English Breast cancer is the most common cancer in women worldwide and the leading cause of cancer-related deaths. Although survival rates are low compared to other cancers, more than 500,000 women worldwide die of breast cancer every year. It is however not a single disease but rather a collection of different diseases with similar appearance but distinct molecular mechanisms.Background: Breast cancer is the most common female malignancy and the leading cause of cancer-related deaths worldwide. Targeted therapy against the main biomarkers estrogen receptor alpha (ER) and human epidermal growth factor receptor 2 (HER2/ERBB2) have greatly improved mortality rates, but ab initio or acquired therapy resistance is common. It is imperative to identify patients who will benef

This paper gives embedding theorems for a very general class of weighted Bergman spaces: the results include a number of classical Carleson embedding theorems as special cases. The little Hankel operators on these Bergman spaces are also considered. Next, a study is made of Carleson embeddings in the right half-plane induced by taking the Laplace transform of functions defined on the positive half

Objective: The aim of this study was to explore healthcare workers' opinions on workplace related health resources relevant to promotion of their health. Participants: 16 registered nurses and 19 assistant nurses, from a medical emergency ward at a medium sized hospital in the south of Sweden, participated in the study. Methods: Eight focus group interviews were conducted, the material was con