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Combined and individual tumor-specific expression of insulinlike growth factor-I receptor, insulin receptor and phosphoinsulin- like growth factor-I receptor/insulin receptor in primary breast cancer : Implications for prognosis in different treatment groups
Clinical trials examining insulin-like growth factor-I receptor (IGF1R)-targeting strategies have emphasized that better predictive biomarkers are required to improve patient selection. Immunohistochemical tumor-specific protein expression of IGF1R, insulin receptor (InsR), and phosphorylated IGF1R/InsR (pIGF1R/InsR) individually and combined in relation to breast cancer prognosis was evaluated in
Infectious complications after out-of-hospital cardiac arrest—A comparison between two target temperatures
Background It has been suggested that target temperature management (TTM) increases the probability of infectious complications after cardiac arrest. We aimed to compare the incidence of pneumonia, severe sepsis and septic shock after out-of-hospital cardiac arrest (OHCA) in patients with two target temperatures and to describe changes in biomarkers and possible mortality associated with these inf
Socioeconomic determinants and metabolic syndrome : Results from the Isfahan Healthy Heart Program
Introduction: The prevalence of metabolic syndrome (MetS) is increasing in Iran. We assessed the relationship between socioeconomic status (SES) and Mets components in the Iranian population. Materi- als and Methods: The sample for this study comprised a random cross-section of men and women from two province districts who participated in the Isfahan Healthy Heart Program (IHHP) in 2007. Each part
Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci
B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. We explored genome-wide association studies of chronic lymphocytic leukaemia (CLL, N = 1,842), Ho
Svensk normering av två bedömningsinstrument för lärare Conner's Teacher Rating Scale (CTRS) och Sutter-Eyberg Student Behavior Inventory - Revised (SESBI-R)
Control and treatment of infected wounds
Wounds are classified as acute or chronic. Acute wounds are divided into traumatic and surgical. In intact skin, the normal bacterial colonization is balanced. A wound jeopardizes this balance and infection may occur. In acute wounds, the presence of particular bacterial species such as Staphylococcus aureus seems to be a risk factor for the occurrence of an infection. To reduce the risk of surgic
Aneurysm shrinkage is compatible with massive endoleak in the presence of an aortocaval fistula : Potential therapeutic implications for endoleaks and spinal cord ischemia
Purpose: To present a patient with ruptured abdominal aortic aneurysm (AAA) and aortocaval fistula who was successfully treated with endovascular aneurysm repair in spite of developing a massive endoleak. Case Report: A 70-year-old man with ruptured AAA and aortocaval fistula was treated with endovascular aneurysm repair (EVAR). During 8 years of followup, he had massive perfusion of the aneurysm
Reflektion och kritisk tänkande : om didaktiska principer och deras tillämpning
Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts
Background: Complement is an important mediator in arterial blood pressure-induced vein graft failure. Previously, we noted activation of cell protective mechanisms in human saphenous veins too. Here we have analyzed whether C4b-binding protein (C4bp), an endogenous complement inhibitor, is present in the vein wall. Methods: Human saphenous vein segments obtained from patients undergoing coronary
Algebraic System Theory as a Tool for Regulator Design
When the characteristics of a system, its environment and the specifications are given in terms of external models it is very natural to use algebraic system theory to design control systems. Different problems of this type are discussed in the paper. It is shown that many design problems can be solved in a uniform, simple and direct way using algebraic system theory. Relations to other methods of
Video Feedback Intervention With Children: A Systematic review
Objective: Present a systematic analysis of the outcome research concerning video feedback (VF) programs. Method: Twentyninestudies published between 1990 and 2014 were examined. They focused on children 0–12 years old and had at least onecontrol group. Results: VF programs were similar in design, with interventions focusing on parental and child behavior, parentalsensitivity and attachment. In 41Objective: Present a systematic analysis of the outcome research concerning video feedback (VF) programs. Method: Twenty- nine studies published between 1990 and 2014 were examined. They focused on children 0–12 years old and had at least one control group. Results: VF programs were similar in design, with interventions focusing on parental and child behavior, parental sensitivity and attachment.
Endoplasmic reticulum stress regulation in hematopoietic stem cells
Adult hematopoietic stem cells (HSCs) reside in bone marrow and are maintained in a dormant state within a special microenvironment, their so-called "niche". Detaching from the niche induces cell cycle progression, resulting in a reduction of the reconstitution capacity of HSCs. In contrast, fetal liver HSCs actively divide without losing their stem cell potentials. Thus, it has been unclear what
A multicentric study to evaluate the use of relative retention times in targeted proteomics
Despite the maturity reached by targeted proteomic strategies, reliable and standardized protocols are urgently needed to enhance reproducibility among different laboratories and analytical platforms, facilitating a more widespread use in biomedical research. To achieve this goal, the use of dimensionless relative retention times (iRT), defined on the basis of peptide standard retention times (RT)
Bacterial suppression of RNA polymerase II-dependent host gene expression
Asymptomatic bacteriuria (ABU) is a bacterial carrier state in the urinary tract that resembles commensalism at other mucosal sites. ABU strains often lack the virulence factors that characterize uropathogenic Escherichia coli (E. coli) strains and therefore elicit weak innate immune responses in the urinary tract. In addition, ABU strains are active modifiers of the host environment, which they i
Deliberate establishment of asymptomatic bacteriuria—a novel strategy to prevent recurrent UTI
We have established a novel strategy to reduce the risk for recurrent urinary tract infection (UTI), where rapidly increasing antibiotic resistance poses a major threat. Epidemiologic studies have demonstrated that asymptomatic bacteriuria (ABU) protects the host against symptomatic infections with more virulent strains. To mimic this protective effect, we deliberately establish ABU in UTI-prone p
Om psalmer och visor : 1937-1986. Tillägg till Allan Arvastson, Den svenska psalmer
A universal result for consecutive random subdivision of polygons
We consider consecutive random subdivision of polygons described as follows. Given an initial convex polygon with d≥3 edges, we choose a point at random on each edge, such that the proportions in which these points divide edges are i.i.d. copies of some random variable ξ. These new points form a new (smaller) polygon. By repeatedly implementing this procedure we obtain a sequence of random polygon
Border aggregation model
Start with a graph with a subset of vertices called {\it the border}. A particle released from the origin performs a random walk on the graph until it comes to the immediate neighbourhood of the border, at which point it joins this subset thus increasing the border by one point. Then a new particle is released from the origin and the process repeats until the origin becomes a part of the border it