There has been an increased interest in ways of measuring the value of new therapeutic options in oncology. An example of this in a European context is the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The purpose of this study is to analyse how the value scales, exemplified with ESMO-MCBS, developed mainly to assist decisions by physicians, relate to other measures of clinical benefit and

Systems approaches for the study of immune signaling pathways have been traditionally based on purified cells or cultured lines. However, in vivo responses involve the coordinated action of multiple cell types, which interact to establish an inflammatory microenvironment. We employed standardized whole-blood stimulation systems to test the hypothesis that responses to Toll-like receptor ligands or

Projections by the Intergovernmental Panel on Climate Change (IPCC) and sea ice forecasts suggest that Arctic sea ice will decline markedly in coming decades. Expected effects on the entire ecosystem include a contraction of suitable polar bear habitat into one or few refugia. Such large-scale habitat decline and fragmentation could lead to reduced genetic diversity. Here we compare genetic variab

This paper presents a simulation model of the temperature's influence on the electromagnetic characteristics of an Interior Permanent Magnet Synchronous Machine (IPMSM). Simulation results of an IPMSM traction machine is presented, and experimental measurements verify the accuracy of the model; no load measurements provide the induced voltage as function of temperature and dynamic tests evaluate t

Organizational image is a contested concept in interdisciplinary research, drawing upon organizational communication, corporate communication, organization, marketing, and public relations studies. As such, organizational image is seen as the impression of an organization that exists among both external stakeholders as well as organizational members themselves as “construed external images” and “d

In many system identification methods, process model parameters are considered stochastic variables. Several methods do not only yield expectations of these, but in addition their variance, and sometimes higher moments. This paper proposes a method for robust synthesis of the proportional-integral-derivative (PID) controller, taking parametric process model uncertainty explicitly into account. The

The IEEE 1687 standard describes reconfigurable structures allowing to flexibly access the instruments existing within devices (e.g., to support test, diagnosis, calibration, etc.), by using configuration modules which act as controllable switches. The increasing adoption of this standard requires the availability of algorithms and tools to automate its usage. The resulting networks might be affec

The objective of this paper is to design a compressor for silicon debug that is suitable in an industrial Nexus environment. The compressor must operate in real-time and must be lossless. Important for the compressor is high compression ratio, low hardware cost and high throughput. We implemented the compression on an FPGA and we compared our implementation in terms of throughput and hardware cost

The C-terminal domain V of the basement membrane proteoglycan perlecan was previously shown to play a major role in extracellular matrix and cell interactions. A homologous sequence of 708 amino-acid residues from Drosophila has now been shown to be 33% identical to mouse perlecan domain V. It consists of three laminin G-type (LG) and epidermal growth factor-like (EG) modules but lacks the EG3 mod

Litterära fabrikationer – det litterära fenomen som vanligen kallas ”bluff” eller ”bedrägeri” – har de senaste decennierna gett upphov till en moralisk och tolkningsteoretisk debatt av starkt polariserad karaktär. I centrum för problematiken står de omtvistade betydelserna av författarens identitet och intention, grundläggande litteraturteoretiska frågor som ställs på sin spets av texter som redan

We report 43 novel genes in the water flea Daphnia pulex encoding 73 predicted neuropeptide and protein hormones as partly confirmed by RT-PCR. MALDI-TOF mass spectrometry identified 40 neuropeptides by mass matches and 30 neuropeptides by fragmentation sequencing. Single genes encode adipokinetic hormone, allatostatin-A, allatostatin-B, allatotropin, Ala(7)-CCAP, CCHamide, Arg(7)-corazonin, DENam

The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one comprises the subapical complex (SAC). It is followed by the zonula adherens (ZA) and, further basally, by

More than 20 years ago, an oxytocin/vasopressin-like peptide, CLITNCPRGamide, was isolated from the locust, Locusta migratoria [Proux JP, et al. (1987) Identification of an arginine vasopressin-like diuretic hormone from Locusta migratoria. Biochem Biophys Res Commun 149:180-186]. However, no similar peptide could be identified in other insects, nor could its prohormone be cloned, or its physiolog

We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. tongicomis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the ide

Neuropeptides and their G protein-coupled receptors (GPCRs) play a central role in the physiology of insects. One large family of insect neuropeptides are the adipokinetic hormones (AKHs), which mobilize lipids and carbohydrates from the insect fat body. Other peptides are the corazonins that are structurally related to the AKHs but represent a different neuropeptide signaling system. We have prev

Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple