On the basis of the dual variational formulation of a class of elliptic variational inequalities, a constitutive relation error is defined for the variational inequalities as an a posteriori error estimator, which is shown to guarantee strict upper bounds of the global energy-norm errors of kinematically admissible solutions. A numerical example is presented to validate the strictly bounding prope

A method is proposed for the solution of boundary-value problems of linear and non-linear 2mth-order Fredholm integro-differential equations. A set of algebraic equations are obtained after introduction of Gauss–Lobatto quadrature and the generalized differential quadrature analog into the weak form description of a Fredholm integro-differential equation. Numerical examples are presented to demons

A procedure to identify the imperfection in thin plates is proposed in this paper. The modified potential energy principle, which serves as the theoretical basis of the identification procedure, is improved to allow for the experimental measurements in static tests. Several typical examples are studied to illustrate the effectiveness of the procedure.

In this paper, a goal-oriented error estimation technique for static response sensitivity analysis is proposed based on the constitutive relation error (CRE) estimation for finite element analysis (FEA). Strict upper and lower bounds of various quantities of interest (QoI) that are associated with the response sensitivity derivative fields are acquired. Numerical results are presented to assess th

For model verification which is mainly focused on the control of discretization errors of numerical results, a posteriori error estimation plays an important role in various numerical tools such as the finite element method. The outputs of interest are usually converted into integral functionals over the problem domain for a posteriori error analysis. Among the available techniques for goal-orient

De samhälleliga och mänskliga kostnaderna för långvarigt utanförskap är förödande.Exemplet med den somaliska integrationen i Minnesota i USA visar att det skulle kunna vara annorlunda – men det kräver att vi gör upp med vår misstänksamhet mot etniskt företagande, skriver Benny Carlsson och Andreas Johansson Heinö.

Two iron complexes featuring the bidentate, nonconjugated N-heterocyclic carbene (NHC) 1,1′-methylenebis(3-methylimidazol-2-ylidene) (mbmi) ligand, where the two NHC moieties are separated by a methylene bridge, have been synthesized to exploit the combined influence of geometric and electronic effects on the ground- and excited-state properties of homoleptic FeIII-hexa-NHC [Fe(mbmi)3](PF6)3 and h

The field of ultrafast science is dependent on either ultrashort laser pulse technology or ultrafast passive detection. While there exists a plethora of sub-picosecond laser pulse solutions, streak cameras are singular in providing sub-picosecond passive imaging capabilities. Therefore, their use in fields ranging from medicine to physics is prevalent. Streak cameras attain such temporal resolutio

Defining psychiatric and mental health nursing has been a challenge for decades, and it is still difficult to find a comprehensive definition. We have identified a possibility to clarify psychiatric and mental health nursing based on humanistic philosophy in a general psychiatric care context. The aim was therefore to identify and synthesize the theoretical frameworks from which psychiatric and me

Det finns ett ganska stort antal bestämmelser om att förvaltningsmyndigheter – ofta organiserade som domstolsliknande nämnder – ska ha medverkan av ordinarie domare. I detta bidrag ges en översikt över när lagstiftningen kräver sådandomarmedverkan. Dessutom diskuteras vad ordinarie domares uppdrag i sådana organ innebär praktiskt och principiellt, främst i statsrättsligt och förvaltningsrättsligt

The doctorate forms the basis for academic careers and the regeneration of academia, and has increasingly become important for other sectors of society. The latter is reflected in efforts on institutional, national as well as supranational levels to change and adapt the doctoral degree to new expectations. As doctoral education is embedded in research, changes in governance and funding of research

Aim: In neuroendocrine cells, large dense-core vesicles (LDCVs) undergo highly regulated pre-fusion processes before releasing hormones via membrane fusion. Significant heterogeneity has been found for LDCV population based on the dynamics of membrane fusion. However, how the pre-fusion status impacts the heterogeneity of LDCVs still remains unclear. Hence, we explored pre-fusion determinants of h

Layered TiS2 has been proposed as a versatile host material for various battery chemistries. Nevertheless, its compatibility with aqueous electrolytes has not been thoroughly understood. Herein, we report on a reversible hydration process to account for the electrochemical activity and structural evolution of TiS2 in a relatively dilute electrolyte for sustainable aqueous Li-ion batteries. Solvate

Background and Purpose: Hippocampal-sparing (HS) is a method that can potentially reduce late cognitive complications for pediatric medulloblastoma (MB) patients treated with craniospinal proton therapy (PT). The aim of this study was to investigate robustness and dosimetric plan verification of pencil beam scanning HS PT. Materials and Methods: HS and non-HS PT plans for the whole brain part of c

The accumulation of tau abnormality in sporadic Alzheimer’s disease is believed typically to follow neuropathologically defined Braak staging. Recent in-vivo PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer’s disease. We, therefore, sought a better understanding of the spatial distri

In Alzheimer’s disease, reconfiguration and deterioration of tissue microstructure occur before substantial degeneration become evident. We explored the diffusion properties of both water, a ubiquitous marker measured by diffusion MRI, and N-acetyl-aspartate, a neuronal metabolite probed by diffusion-weighted magnetic resonance spectroscopy, for investigating cortical microstructural changes downs

Formation of amyloid-β (Aβ) fibrils is a central pathogenic feature of Alzheimer's disease. Cell-secreted extracellular vesicles (EVs) have been suggested as disease modulators, although their exact roles and relations to Aβ pathology remain unclear. We combined kinetics assays and biophysical analyses to explore how small (

En ambitiös politik och effektiva styrmedel behövs för en snabb klimatomställning av samhället. Det finns en stor palett av möjliga styrmedel och olika styrmedel fungerar olika bra beroende på vilka hinder för omställningen de är tänkta att hantera. Men även om det i stort är känt vad som behöver göras, vilka styrmedel som finns tillgängliga och hur de bäst kan användas är en annan fråga hur dessa

We present combined theoretical and experimental work investigating the angle-resolved phases of the photoionization process driven by a two-color field consisting of an attosecond pulse train and an infrared pulse in an ensemble of randomly oriented molecules. We derive a general form for the two-color photoelectron (and time-delay) angular distribution valid also in the case of chiral molecules