The present paper serves as an overview of recent developments by the author on the assessment and quantification of robustness of structures; the paper aims in this sense not to present any new results but collects approaches and results from previous publications. A general decision theoretical approach to the assessment and management of structural robustness is outlined. Structural robustness

Whatever type of human and economic activity we study, we find that it is not evenly spread out in space, but instead concentrated to a rather limited number of countries, regions and cities. What in particular is noticeable is that certain places, typically large city regions, host a large share of the wealth and knowledge generated in the modern world. Despite what we can read in the popular pre

Om europeisk invandring till USA.

The affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presenting cognate antigens likely determines whether T cells initiate immune responses, or not. There exist few measurements of two-dimensional (2D) TCR-MHC interactions, and the effect of auxiliary proteins on binding is unexplored. Here, Jurkat T-cells expressing the MHC molecule HLA-DQ8-glia-α1 and th

Background: With the implementation of a research project providing whole genome sequencing (WGS) to all pediatric cancer patients in Denmark (2016–2019), we sought to investigate healthcare professionals' views on WGS as it was actively being implemented in pediatric oncology. Methods: Semistructured interviews were carried out with pediatric oncologists, clinical geneticists, and research coordi

Background: The environment where we humans live provides the fundamental requirements we need to survive – food to eat, water to drink, and air to breathe. The quality of these elements has a major impact on human health, as they can contain substances that are detrimental to health. These we call environmental pollutants. This thesis explores the effects of exposure to air pollutants in particul

Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). Another feature of the disease is represented by formation of abnormal protein aggregates, known as Lewy Bodies (LBs),

As more offshore wind parks are commissioned, the focus will inevitably shift from a planning, construction, and warranty focus to an operation, maintenance, and investment payback focus. In this latter case, both short-term risks associated with wind turbine component assemblies, and long-term risks related to integrity of the support structure, are highly important. This research focuses on the

A prototype of wind turbines in 5 megawatt class was built and tested at the first German offshore wind energy test field in the North Sea. In order to investigate dynamic behaviors under a complex state of loads, a continuous dynamic monitoring system was implemented by Federal Institute for Material Research and Testing (BAM). It recorded structural responses and environmental/operational variab

Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis. Integrating label-free quantitative proteomics data into genome-wide metabolic modeling, we built up a model that predicts the metabolic fluxes in ECs when cultured on a tridimens