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Calpain, a Ca2+-dependent cysteine protease, has been implicated in neuronal apoptosis following spinal cord injury. In this study, activation of calpain was investigated in motor neurons of adult spinal cord slices from the mouse, using a cell-permeable fluorogenic calpain substrate and Western blotting. Calpain was rapidly activated in the motor neurons of excised spinal cord slices and calpain
In addition to the two known compounds neotautenol [2] and erythrinassinate B [4], two new compounds, an isoflavanone named sigmoidin J [1] and a coumestan derivative named sigmoidin K [3], have been isolated and characterized from the root bark of the Cameroonian medicinal plant Erythrina sigmoidea. Their structures have been established as 7, 4'-dihydroxy-2',5'-dimethoxy-6'(gamma, gamma-dimethyl
The North West Caucasian language Kabardian has a minimal vowel system, the analysis of which has engendered significant controversy. Phonetically, Kabardian is interesting for the extensive assimilation of its few vowel phonemes to the surrounding consonants. Two published descriptions of these assimilations by J. C. Catford ("The Kabardian Language," Maitre Phonetique, 3rd series, 1942, 77, 15-1
Breast cancer survival differs 9 percentage points between the neighbouring countries of Denmark and Sweden. The authors' aim was to analyse whether this was caused by early detection in Sweden. The extent of disease and outcome was compared in two population-based breast cancer cohorts in 1983-1989. Breast cancer management was decentralized in Denmark without mammography screening whereas treatm
The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler and Diskhaler. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double-blind, double-dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50, 100, 200, and 400 microg, were given on one study day at intervals of 30 min. On another stud
Insertion of lithium in anatase TiO2, giving LixTiO2, is performed under ultrahigh vacuum (UHV) conditions and studied using synchrotron radiation based electron spectroscopy. Core level photoemission spectra are directly compared to results obtained after electrochemical insertion, illustrating the usefulness of the UHV approach. The growth of a state of mainly Ti 3d character in the band gap is
Stress management was studied in male patients with solvent-induced chronic toxic encephalopathy (TE) of types 2A (TE 2A, n = 31) and 2B (TE 2B, n = 26). The patients were compared with a healthy reference group (n = 57). Self-reported symptoms (90-item Symptoms Checklist [SCL-90]), sense of coherence, coping strategies, and level of mastery were measured. As expected, both TE groups reported high
ATP-sensitive K(+) channels (K(ATP) channels) of pancreatic beta-cells play key roles in glucose-stimulated insulin secretion by linking metabolic signals to cell excitability. Membrane phosphoinositides, in particular phosphatidylinositol 4,5-bisphosphates (PIP(2)), stimulate K(ATP) channels and decrease channel sensitivity to ATP inhibition; as such, they have been postulated as critical regulat
Pyridoxine-dependent seizures are rare in newborn infants, although recent data suggest that the prevalence probably is underestimated. In all newborn infants with recurrent epileptic seizures the general recommendation is to administer pyridoxine and simultaneously record an electroencephalogram (EEG). Conclusion: One infant with pyridoxine-responsive seizures and another with pyridoxine-dependen
1 We model the potential vegetation and annual net primary production (NPP) of China on a 10' grid under the present climate using the processed-based equilibrium terrestrial biosphere model BIOME3. The simulated distribution of the vegetation was in general in good agreement with the potential natural vegetation based on a numerical comparison between the two maps using the DeltaV statistic (Delt
Innehåll: Forskningsbehov inom ballastområdet; Lättballast ; Ballastens funktion i betong ; Testmetoder och kvalitetskriterier för ballast till betong
För att kunna beräkna tiden till aktivering av en rökdetektor krävs en beskrivning av strömnings- och temperaturförhallandena samt röktätheten i detektorns omgivning. Den transienta utvecklingen av strömnings-, temperatur- och koncentrationsförhållandena i ett rum med en brandkälla och av godtycklig geometri kan simuleras med hjälp av sk fältmodeller. I denna rapport presenteras resultaten fran en
Properties of nonionic triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) (EOnPOmEOn) in aqueous solution and their interaction with the ionic surfactants sodium dodecyl sulfate and hexadecyltrimethylammonium chloride have been investigated by static and dynamic light scattering, high sensitivity differential scanning, and isothermal titration calorimetry. The studie
