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Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to ren
Insect distributions are shifting rapidly in response to climate change and are undergoing rapid evolutionary change. We investigate the molecular signatures underlying local adaptation in the range-expanding damselfly, Ischnura elegans. Using a landscape genomic approach combined with generalized dissimilarity modelling (GDM), we detect selection signatures on loci via allelic frequency change al
Aging entails health challenges globally, but pertinent data from low-income countries like Uganda remains scarce. A cross-sectional study was carried out at Mulago National Referral Hospital in Kampala, among 134 patients (38% men and 62% women) aged ≥60 years. Data was collected on sociodemographic characteristics, medical disorders, cognitive function, hearing handicap, and functional status, t
Text visualization techniques often make use of automatic text classification methods. One of such methods is stance analysis, which is concerned with detecting various aspects of the writer's attitude towards utterances expressed in the text. Existing text visualization approaches for stance classification results are usually adapted to textual data consisting of individual utterances or short me
Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This po
From early childhood, Hanna, born with Spinal Muscular Atrophy II, has adhered to a standing posture for all her independent locomotion. Aim: To investigate why Hanna in childhood chose to stand and the meaning that standing holds for Hanna as an adult. Method: Single case study of a single person, Hanna, based on her contemporary statements as an adult about her lived experience from childhood, i
Monte Carlo simulations were used to determine the contrast-to-noise ratio of acoustooptical tomographic imaging with slow light filters versus possible imaging depth. Both reflection and transmission setups were considered. The theoretical model showed that imaging through 12 cm of breast tissue could be plausible.
A paleomagnetic and chronogical study has been performed on the Turinge gabbro-diabase formation and on a cross cutting basic dyke in central Sweden and on the Joulovaara gabbro intrusion in northern Sweden in the Fennoscandian Shield. U-Pb age of baddeleyite and 40Ar/39Ar ages of hornblende and biotite reveal a cooling history of the deep gabbro-diabase intrusion in Turinge. The cooling is sugges
Soluble guanylyl cyclase (sGC) is an effector enzyme of nitric oxide (NO). Recent work has unravelled how levels of this enzyme are controlled, and highlighted a role in vascular disease. We provide a timely summary of available knowledge on transcriptional regulation of sGC, including influences from the NOTCH signalling pathway and genetic variants. It is speculated that hypertension-induced rep
Additive manufacturing and its related techniques have frequently been put forward as a promising candidate for planetary in-situ manufacturing, from building life-sustaining habitats on the Moon to fabricating various replacements parts, aiming to support future extra-terrestrial human activity. This paper investigates the mechanical behaviour of lunar regolith simulant material components, which
BACKGROUND: Sense of Coherence (SOC) is important for successful adaptation and mental well-being in people with life-long medical conditions. Late effects of polio (LEoP) often lead to a life-long disability, but no study has assessed SOC in this population. OBJECTIVE: To assess SOC in persons with LEoP and to explore the association between SOC, demographics (age, gender, marital status and leve
Pharmacotherapy of epilepsy is usually initiated after two or more unprovoked seizures, a decision that should be made after assessment of the individual risk of further seizures. Antiepileptic drugs (AEDs) are selected based on documented efficacy for the type of seizures, the epilepsy and possible epilepsy syndrome of the patient, taking potential adverse effects and comorbidity into account. Fo
Innovation auditing is a well-established practice used by managers to identify strengths and weaknesses in innovation. Existing audit frameworks fall short, however, because they neglect three major trends that currently transform the innovation landscape. These trends are as follows: 1) a shift from closed to more open models of innovation (“openness”), 2) a shift from providing physical product
The effect of the support material and chemical state of Rh in Rh/A2O3 and Rh/SiO2 model catalysts during CO2 hydrogenation were studied by a combined array of in situ characterisation techniques including diffuse reflectance infrared Fourier transform spectroscopy, energy-dispersive X-ray absorption spectroscopy and high-energy X-ray diffraction at 250-350 °C and atmospheric pressure. CO2 methana
Cardiac resynchronization therapy (CRT) has proven prognostic benefits in patients with heart failure (HF) with left bundle branch block (LBBB) QRS morphology. Electrocardiographic left atrial (LA) abnormality has been proposed as a noninvasive marker of atrial remodeling. We aimed to assess the impact of electrocardiographic LA abnormality for prognosis in patients with HF treated with CRT. Basel
The aim of this work is to study the performance of nanoporous carbon membrane for hydrogen recovery from off-gas streams. The study is based on a rigorous mathematical model which can predict the performance of nanoporous selective surface flow (SSF) carbon membrane. Basically, the developed model is based on two transport mechanisms: the dusty gas flow through porous media and the surface adsorp
To mimic the active sites of the hydrolytic enzyme zinc phosphotriesterase, a new dinucleating unsymmetric ligand, PICIMP (2-([2-hydroxy-5-methyl-3-(([(1-methyl-1H-imidazol-2-yl)methyl](pyridin-2-ylmethyl)amino)methyl)benzyl][(1-methyl-1H-imidazol-2-yl)methyl]amino)acetic acid), has been synthesized and characterized. The hydrolytic efficacy of the complex solution (PICIMP/ZnCl2 = 1:2) has been in
Early life environments shape phenotypic development in important ways that can lead to long-lasting effects on phenotype and fitness. In reptiles, one aspect of the early environment that impacts development is temperature (termed 'thermal developmental plasticity'). Indeed, the thermal environment during incubation is known to influence morphological, physiological, and behavioral traits, some o
