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The inquiry into topicality calls for a deeper understanding of explicit "topic markers" such as apropos and concerning, which are found in many if not all the languages of Europe. From a syntactic perspective, phrases introduced by such expressions are not identifiable with any of the construction types that alter the information structure of the clause involving the left periphery. Thus, apropos
This volume contains innovative papers that target the linguistic status of topic at the interface between grammar and discourse. The purpose of the volume is to discuss the universal properties of topics and, at the same time, to document the range of discourse-semantic and grammatical variation within this phenomenon in European languages. The volume is structured accordingly: (i) theoretical fo
This paper presents a novel analysis of the discourse properties of the phenomenon called "Stylistic Fronting" (SF). The widely held view according to which Stylistic Fronting has no discourse-semantic effects in Icelandic, but is related to topic or focus interpretation in Romance, is challenged. It is argued that SF is not simply triggered by formal features but has relevance for information str
Honeybees are one of our most important insects, not only for their pollination services but also for their production of honey. Honey is the main food for honeybees, produced from collected nectars and transported to the hive. Humans have consumed this mysterious food and applied it since ancient times in traditional medicine around the world. In 2005 we discovered an unknown key to honeybees’ he
This paper discusses early medieval stone towers on Gotland. It summarizes the scholarly interpretations of their functions and dating,and analysis the towers in different spatial settings; towers at farmsteads, at churches and at harbours. Generally, we should see the towers on Gotland as concrete symbols of the presences of different types of elite. The towers at churches and farms reflects the
In the first part of this chapter we illustrate how a big data project can be set up and optimized. We explain the general value of big data analytics for the enterprise and how value can be derived by analyzing big data. We go on to introduce the characteristics of big data projects and how such projects can be set up, optimized and managed. Two exemplary real word use cases of big data projects
Exercise during cancer treatment improves cancer-related fatigue (CRF), but the importance of exercise intensity for CRF is unclear. We compared the effects of high- vs low-to-moderate-intensity exercise with or without additional behavior change support (BCS) on CRF in patients undergoing (neo-)adjuvant cancer treatment. This was a multicenter, 2x2 factorial design randomized controlled trial (Cl
Urban agglomeration is an important strategy used to promote economic development and urbanization in China. Understanding the structure of urban agglomeration is therefore essential for policy-makers and planners. In this study, the Beijing–Tianjin–Hebei urban agglomeration (BTHUG) is explored through a proposed spatial network analytical framework and a large mobile phone data set (over 20 milli
Background and Purpose: The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month af
Background: Acute myeloid leukemia (AML) patients have limited effect from T-cell-based therapies, such as PD-1 and CTLA-4 blockade. However, recent data indicate that AML patients with TP53 mutation have higher immune infiltration and other immunomodulatory therapies could thus potentially be effective. Here, we performed the transcriptional analysis of distinct T-cell subpopulations from TP53-mu
This study addresses a response to shifting baseline syndrome (SBS), a syndrome implying that land managers' acceptance of environmental change declines gradually due to lack of historical knowledge. Some actions to counteract SBS are haunted by methodological problems associated with measuring natural states and ignoring societal effects on ideas of naturalness. To balance methodological discussi
Background: Host–microbe interactions may influence dermatitis pathogenesis in the nasomaxillary folds of French bulldogs, which is often complicated by secondary bacterial and fungal infections. Objective: To assess the skin-fold microbiome in systemically healthy French bulldogs and to determine the influence of topical medications on this microbiome. Animals: Nineteen healthy French bulldogs. M
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients. Worryingly, Acinetobacter have become multi- and extensively drug resistant (MDR/XDR) over the last few decades. The complement system is the first line of defense against microbes, thus it is hig
The paleobiogeography of Early–Middle Devonian (Pragian–Eifelian) brachiopods from West Gondwana was assessed to determine any potential controls (regional climatic differences or global eustasy) that may have driven bioregionalization. The Pragian–Eifelian interval of West Gondwana was examined because work by previous authors suggested that this was a period when regionally extensive areas of pr
Previous studies have shown that high intratumoral stromal content is associated with a worse prognosis in breast cancer, especially in the triple-negative subtype. However, contradictory results have been reported for estrogen-receptor-positive (ER+) breast cancer, indicating that the prognostic role of intratumoral stromal content may be subtype-dependent. In this study, we investigated the impo
Environmental exposures to a myriad of chemicals are associated with adverse health effects in humans, while good nutrition is associated with improved health. Single chemical in vivo and in vitro studies demonstrate causal links between the chemicals and outcomes, but such studies do not represent human exposure to environmental mixtures. One way of summarizing the effect of the joint action of c
Early adolescence is the period of the emergence of most mental disorders contributing significantly to the mental health burden globally, including India. The major challenges in India are early identification of mental health problems, treatment gap, lack of professionals, and interventions that address the same. Our review aimed to assess the effectiveness of mental health interventions among a
