Autophagy is an essential quality control mechanism for maintaining organellar functions in eukaryotic cells. Defective autophagy in pancreatic beta cells has been shown to be involved in the progression of diabetes through impaired insulin secretion under glucolipotoxic stress. The underlying mechanism reveals the pathologic role of the hyperactivation of mechanistic target of rapamycin (mTOR), w

BACKGROUND: To clarify, in a national sample, associations between risk for seven psychiatric and substance use disorders and five key transitions in Sweden's public educational system. METHODS: Swedish-born individuals (1972-1995, N = 1 997 910) were followed through 12-31-2018, at mean age 34.9. We predicted, from these educational transitions, risk for major depression (MD), obsessive-compulsiv

IntroductionSpeech in children with cleft palate can be affected by velopharyngeal dysfunction, which persists after primary palate repair. The incidence of surgery to correct velopharyngeal dysfunction in this patient group has previously been reported as 2.6–37%. We aimed to investigate the incidence of velopharyngeal dysfunction surgery in Swedish children with cleft palate and to examine poten

Objective: To describe the clinical and ultrasound characteristics of recurrent granulosa cell and Sertoli–Leydig cell tumors. Methods: This was a retrospective observational study performed at Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS, Rome (Gemelli center). Patients with a histological diagnosis of recurrent granulosa cell tumor o

Impairment of intestinal epithelium is a typical feature of inflammatory bowel disease (IBD) that causes leakage of bacteria and antigens from the intestinal lumen and thus results in persistent immune activation. Hence, healing and regeneration of the damaged gut mucosa is a promising therapeutic approach to achieve deep remission in IBD. Currently, available systemic therapies have moderate effe

We present a radial velocity (RV) analysis of TOI-1136, a bright Transiting Exoplanet Survey Satellite (TESS) system with six confirmed transiting planets, and a seventh single-transiting planet candidate. All planets in the system are amenable to transmission spectroscopy, making TOI-1136 one of the best targets for intra-system comparison of exoplanet atmospheres. TOI-1136 is young (∼700 Myr), a

Long-span floors are particularly sensitive to footfall-induced vibrations, making their analysis and design critical for ensuring occupant comfort. Cross-laminated timber (CLT) panels have high stiffness relative to their self-weight and are commonly made of spruce. Hardwoods such as birch and beech possess higher stiffness and mass density, which can potentially improve the vibrational performan

Softwood species are the most commonly used species in structural applications in north-ern Europe. However, in the last couple of years, utilization of hardwoods has gatheredincreased momentum, and different hardwood species, such as birch, have even been uti-lized in cross laminated timber and glued laminated timber [1]. In general hardwoodsshow an increase in strength and stiffness as compared

Background: Medical student master’s theses are often carried out as research projects, and some are published as research papers in journals. We investigated the percentage of master’s theses conducted by 5th -year students at the Medical Degree Program at Lund University, Sweden, that subsequently served as the basis for research publications. In addition, we explored both student and supervisor

Climate change is expected to increase the frequency and intensity of extreme weather events. Individualized and timely advice on how to cope with thermal stress is therefore needed to encourage protective strategies and reduce morbidity and even mortality among vulnerable populations. Such advice can be based on integration of human thermal models, weather forecasts and individual user characteri

Sveriges neuro­psykologers förening: Ökningen av adhd-diagnoser är ett samhälls­problem som inte kan lösas enbart av vården, och lösningen finns knappast i en växande mängd av utredningar, diagnoser och medicinering.

Patientsäkerheten är hotad vid neuropsykiatriska utredningar, och främst gäller det adhd och autism. Alltför snäva tidsramar ger inte utrymme för den noggrannhet som krävs vid utredningar, skriver flera debattörer.

PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a p

Biografisk artikel om Dagmar Karlberg (1866-1845), Kalmars första och Lunds universitets sjuttonde studentska, fil lic i matematik men främst verksam som "utländsk korrespondent" och översättare, känd för att ha kunnat 28 språk.

This article presents an online survey with 323 respondents and 28 semi-structured interviews performed to investigate people’s perceptions of fire evacuation training and their attitudes towards it. The survey results showed that respondents with experience in fire evacuation training judge a fire in buildings that feature non-combustible materials to be more severe than other people, but no effe

The question of the rationality of conspiratorial belief divides philosophers into mainly two camps. The particularists believe that each conspiracy theory ought to be examined on its own merits. The generalist, by contrast, argues that there is something inherently suspect about conspiracy theories that makes belief in them irrational. Recent empirical findings indicate that conspiratorial thinki

Blinks, the closing and opening of the eyelids, are used in a wide array of fields where human function and behavior are studied. In data from video-based eye trackers, blink rate and duration are often estimated from the pupil-size signal. However, blinks and their parameters can be estimated only indirectly from this signal, since it does not explicitly contain information about the eyelid posit