Background: Amyloid-beta (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe (MTL). However, there is evidence that age-related Aβ-independent tau pathology is present outside the MTL (Kaufman et al., Acta Neuropathol, 2018). We examine tau deposition determined by positron emission tomography (PET) in regions typically involved earlier/later in AD and do

《在幽昏中顯影：港中對話中國獨立紀錄片2014-2020》一書以導演、學者、觀眾對話的形式，討論了中國獨立紀錄片研究會（香港）2014至2020年期間展映、製片、發行的獨立電影。我們從中選擇了記錄較為完整的“叛逆中國”、“飛越瘋人院”、“情慾中國”三個展映單元的獨立紀錄片討論，以及針對夾邊溝右派農場倖存者記憶、維吾爾和新疆議題、三自教會、地下知識分子、前政府高官、工人抗爭等18部影片的映後交流文本或者導演訪談文本，形成本書“性、性別與女性主體”、“權利與政治”、“歷史與記憶”、“放逐與流亡”四個部分的主要內容。本書還收入研究會參與製片的《喊叫與耳語》首映對談，曾金燕對艾未未在跨國視野（流亡處境）下關於藝術（如《人流》）、社會行動和審查的兩次訪談，曾金燕對應亮半自傳劇情片《自由行》的訪談、曾金燕對艾曉明關於性別、紀錄片和社會行動的訪談、曾金燕與王月眉關於在香港八年“邊緣”經驗的筆談。額外收入

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast can

Background: Different tau biomarkers become abnormal at different stages of Alzheimer’s disease (AD), with CSF p-tau typically being elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture the earliest changes of tau accumulation, we selected a group of amyloid-β-positive (A+) individuals with elevated CSF p-tau levels but ne

Extensive anti-government protests were held in Poland in October 2020 related to accumulated social tensions due to COVID-19 pandemic among others. We attempt a question of how understanding communication patterns among protesters could possibly support epidemiological harm reduction campaigns. To do so, we analysed tweets in Polish language with hashtags: #Strajkkobiet representing pro-choice mo

In this paper, we present a global solution to a nonlinear H-infinity optimal control problem for control-affine systems with an associated potential function. We also give a closed-form expression for an optimal controller and demonstrate its potential for sparsity. This paper thus advances a recent result which considers the same problem restricted to systems with symmetric state matrix and nonl

Background: Markers of downstream events are a key component of clinical trials of disease-modifying therapies for Alzheimer’s disease (AD). Morphometric metrics like cortical thickness are established measures of atrophy but are not sensitive enough to detect Aβ-related changes that occur before overt atrophy become visible. We aimed to investigate to what extent diffusion MRI can provide sensiti

Constructing simulation models can be a complex and time-consuming task, in particular if the models are constructed from scratch or if a general-purpose simulation modeling tool is used. In this paper, we propose a model construction framework, which aims to simplify the process of constructing discrete event simulation models for emergency medical service (EMS) policy analysis. The main building

The article presents a semantic theory suggesting that equivalence and polyvalence are closely connected phenomena. The connection between them is utilised by making equivalence the basis of an argument for polyvalence within semantics, or in other terms, for a stratified semantics encompassing two levels of description. This argument from equivalence lends new support to frameworks assuming a str

Concerns about water and energy security have enhanced the water–energy nexus studies. However, even being well explored, some crucial aspects lack further analyses, such as the historical background of the relationship between the resources. This kind of analysis provides an in-depth understanding of the current situation and future perspectives and must, therefore, be included in WEN investigati

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly

The Astropy Project supports and fosters the development of open-source and openly developed Python packages that provide commonly needed functionality to the astronomical community. A key element of the Astropy Project is the core package astropy, which serves as the foundation for more specialized projects and packages. In this article, we summarize key features in the core package as of the rec

Lunds universitets yttrande över den s k arkivutredningen.

Social policy developed as a research field and academic discipline to ensure protection from social risks in the era of emerging capitalism and industrialization. While welfare states have successfully increased their citizens’ wellbeing, they have also contributed to the ecological crisis, while the shared scientific understanding of exceeded planetary boundaries and worsening climate change sce

Over the last 7 years, a multidimensional crisis in Venezuela has resulted in massive emigration. Over 7 million have fled the country, with more than 2.4 million seeking to settle in Colombia. Of these, as of 2021, more than 1 million were undocumented, but the situation has started to change with the implementation of an ambitious migrant regularisation scheme. Regularisation promises access to

AimTo describe child health care nurses' experiences of teaching infant massage in parent groups.DesignThis was an exploratory-descriptive qualitative study based on individual interviews.MethodQualitative semi-structured interviews were conducted with child health care nurses (N = 9) according to the COREQ guidelines and analyzed with qualitative content analysis.ResultsFive categories were ident

Artiklarna i detta nummer bearbetar frågor om levbarhet, motstånd och hopp på olika sätt, utifrån olika disciplinära kontexter och med en bredd av material. Frågan som ställs handlar om vilka som anses ha liv värda att skydda, och vad som gör livet levbart för de som positioneras utanför det begripliga och därmed skyddsvärda och sörjbara. Vi förhåller oss här till Butlers analys och förslag att täThe articles in this issue address issues of livability, resistance and hope in different ways, from different disciplinary contexts and with a wide range of materials. The question posed is who is considered to have lives worth protecting, and what makes life liveable for those who are positioned outside the intelligible and thus worthy of protection and care. Here we relate to Butler's analysis

Evidence is lacking on how to understand the reasons for variations, both in prevalence of ADHD and ADHD medication prescribing patterns in children and adolescents, within Region Skåne. These variations are not in line with current national clinical guidelines and seem to have increased over time. This qualitative interview study illuminates pediatric psychiatrists' attitudes toward ADHD and thei

AbstractBackground We aimed to evaluate if optimization by maximizing QRS duration (QRSd) reduction is feasible in an all-comercardiac resynchronization therapy (CRT) population, and if reduced, QRSd is associated with a better clinical outcome.Methods Patients with LBBB receiving CRT implants during the period 2015–2020 were retrospectively evaluated. Implantsfrom 2015–2017 were designated as conBackgroundWe aimed to evaluate if optimization by maximizing QRS duration (QRSd) reduction is feasible in an all-comer cardiac resynchronization therapy (CRT) population, and if reduced, QRSd is associated with a better clinical outcome.MethodsPatients with LBBB receiving CRT implants during the period 2015–2020 were retrospectively evaluated. Implants from 2015–2017 were designated as controls. S