Systemic infusions of angiotensin II (AngII) rapidly induce large, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor(s), AngII generates reactive oxygen species (ROS) and produces Ca(2+) influx into cells, leading to activation of a plethora of signaling cascades, including e.g. calcineurin, and small GTPases, such as Rac-1 and

A long chain of pulse-coupled oscillators was studied. The oscillators interacted via a phase response curve similar to those obtained from pacemaker cells in the heart. The natural frequencies were random numbers from a distribution with finite bandwidth. Stable frequency-entrained states were shown always to exist above a critical coupling strength. Below the critical coupling, the probability t

In the beginning of the 1990s, the Tunisian Ministry of Agriculture launched an ambitious program for constructing small hillside reservoirs in the northern and-central region of the country. At present, more than 720 reservoirs have been created. They consist of small compacted earth dams supplied with a, horizontal overflow weir. Due to lack of hydrological data and the area's extreme floods, ho

A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) in 2001. The assessment included a review of radiotherapy techniques in current use in Sweden. The following conclusions were drawn: Radiotherapy demands adequate knowledge of diagnostic methods, anatomy, cancer biology and of the physical and biological properties

The adsorption of modified polyacrylamides (PAM) at the silica surface has been studied by ellipsometry. To study the influence of the type of modification of the polyacrylamide on the adsorption behaviour, we have used cationic, anionic and hydrophobically modified polyacrylamides with varying charge density and degree of hydrophobisation. The adsorbed amount and adsorbed layer thickness were obt

Policy proposals for the management of water resources need to take into account two emerging themes: public involvement in the development of resource use policy and water management on a catchment level. The CATCH-model, a decision support system for catchment-based water management, builds on the use of ‘discourse and deliberation’ within stakeholder groups to define relevant socio-economic par

Due to the scarcity of reliable antibodies, RBC typing for Doa and Dob is notoriously difficult. Inaccurate typing can place patients at risk for hemolytic transfusion reactions. The molecular basis of the DOA/DOB polymorphism is associated with three nucleotide changes:378 C>T, 624 T>C,and 793 A>G of DO. While the 378 C>T and 624 T>C are silent mutations, the 793A>G polymorphism in codon 265 enco

Nanoparticles were used as a pseudostationary phase in capillary electrochromatography (CEC) electrospray ionisation-mass spectrometry (ESI-MS) for separation of both neutral analytes by a reversed phase mechanism, as well as for cationic analytes by a cation exchange mechanism. Nanoparticles suspended in electrolyte, were injected as a plug prior to the sample using a partial filling technique (P

High-spin states of the isospin T-z = -1/2 nucleus Ni-55 have been identified for the first time by means of the reaction Si-28(Ar-36,2 alpha n) at 143 MeV beam energy. The GAMMASPHERE array together with ancillary detectors was used to detect gamma rays in coincidence with evaporated light particles. The level scheme of Ni-55 comprising four transitions is compared to its mirror partner Co-55 and

One of the purposes of the project was to develop the method of preparation of 3D macroporous hydrogel with a structure of interconnected pores by the use of noncovalent interactions. The combination of chitosan and noble-metal complexes was investigated as cross-linking agents for the preparation of ionic cryogels (ICs). Furthermore, the treatment of the ICs containing gold complex by glutaraldeh

BackgroundVariants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease. MethodsThe Genetic Epidemiology of Parkinson's Disease Consortium recently

The inner relative humidity (RH) and degree of saturation (S) of high-performance concrete cured for 2 years in water or 3% NaCl solution were measured at three different levels from the concrete surface (outer layer 0 to 16 mm, middle layer 16 to 32 mm, and inner layer 32 to 50 mm). The effects of many factors, such as water-to-cement (w/c) ratio, content of silica fume, and air content, were inv

The research work that is presented in this thesis aims at mapping out the various mechanisms which control the process of steel corrosion in concrete. The process of corrosion is illustrated with a schematic model where the service life is divided into a period of initiation and a period of propagation. The time up to the initiation of the corrosion process is determined by the flow of penetratin

Context: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. Objective: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n

A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the