Geospatial data have been pervasive and indispensable for various real-world application of e.g. urban planning, traffic analysis and emergency response. To this end, the data integration and knowledge transfer are two prominent issues for augmenting the use of geospatial data and knowledge. In order to address these issue, Semantic Web technologies have been considerably adopted in geospatial dom

Solid tumors, including gliomas, still represent a challenge to clinicians and first line treatments often fail, calling for new paradigms in cancer therapy. Novel strategies to overcome tumor resistance are mainly represented by multi-targeted approaches, and cell vector-based therapy is one of the most promising treatment modalities under development. Here, we show that mouse bone marrow-derived

Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled f

This study presents the results of surgery in the elderly for primary hyperparathyroidism (PHPT) from a single institution's experience. We retrospectively analyzed 898 cases of surgically treated PHPT, divided into two groups: 135 elderly patients (A) and 763 patients younger than 65 years (B). PHPT was symptomatic in 68.8 per cent patients in group A and in 81.6 per cent in group B. Unilateral t

Background: Parents’ birth experiences affect bonding with their infant, which in turn may influence the child's future health. Parents’ satisfaction with childbirth is multi-dimensional and dependent on both expectations and experiences. Increasing involvement of partners in intrapartum care may lead to an assumption that the birthing couple shares attitudes and expectations of intrapartum care.

Objective: To evaluate the evolution of cognitive impairment in relation to cerebrospinal fluid (CSF) profiles of amyloid-β (Aβ), total-Tau and phosphorylated-Tau in Parkinson's disease (PD). Methods: Prospective, longitudinal, observational study up to 10 years with follow-up every 2 years. We assessed CSF profiles in 415 patients with sporadic PD (median age 66; 63% men) and 142 healthy controls

Perhaps the most important unmet clinical need in Parkinson's disease (PD) is the development of a therapy that can slow or halt disease progression. Extensive preclinical research has provided evidence for the neurorestorative properties of several growth factors, yet only a few have been evaluated in clinical studies. Attempts to achieve neuroprotection by addressing cell-autonomous mechanisms a

Changes to agricultural systems in Sub-Saharan Africa are subject to a wide range of drivers, often resulting in rapid and nonlinear dynamics. Such dynamics are however rarely recognized in studies of trends and drivers, which usually rely on assumptions of gradual progressions, and often using highly aggregated data. This paper addresses this lack of recognition and understanding of nonlinear pro

Quinolines, indolizines, and coumarins are well known structural elements in many biologically active molecules. In this report, we have developed straightforward methods to incorporate quinoline, indolizine, and coumarin structures into galactoside derivatives under robust reaction conditions for the discovery of glycomimetic inhibitors of the galectin family of proteins that are involved in immu

Introduction: The demographic changes with population ageing and a rapidly growing share of very old peoplewill put an increasing pressure on the health and social care system. In order to both restrict early retirement and force people to extend their working life reforms are changing pension systems in many European countries. Besides that older people have to extend their working life it is imp

Importance: Childhood appendicitis is commonly complicated by gangrene and perforation, yet the causes of complicated appendicitis and how to avoid it remain unknown. Objective: To investigate whether children with IgE-mediated allergy have a lower risk of complicated appendicitis. Design, Setting, and Participants: This retrospective cohort study included all consecutive patients younger than 15

To study the intergenerational dynamics of productivity, social mobility and demographic change of any contemporary society is a challenge. To do this for a pre-industrial society at the southern tip of Africa seems almost impossible. Yet this is the purpose of the Cape of Good Hope Panel, an annual panel data set–still under construction–of Cape Colony settler tax records over almost two centurie

A heterogeneous catalyst system for Suzuki and Heck coupling reactions was developed using polyoxometalates as supports for palladium. The catalyst system was synthesized in a one step process using sodium phosphotungstate and palladium acetate. We used the supported catalyst in organic media without the need for special ligands. Substantial activity was observed after several recycles. The cataly

Globalisation has led to the transformation and proliferation of urban borders. Old hierarchies and relations between centres and sub-centres and centres and peripheries are challenged, and new alliances between different places and districts are formed. How can urban design and urban design research meet the challenges of a complex and quickly transforming multi-scalar society? In this article I

Eight new species of Hieracium sect. Tridentata, namely H. antrorsum, H. quercifolium,H. stenianum, H. vestrogothicum, and H. vetlandaënse are described from the Götaland region (southern Sweden), H. grothii from Norrbotten in the Norrland region(northeast Sweden), and H. sparsifolium var. suppansum Johanss. and H. adampliatumvar. pilosius Ohlsén are raised to specific rank as H. suppansum and H.

The purpose of this paper is to understand the relationship between the formal (governance established in law) and informal institutions (governance not established in law) that underpin the planning, operation and improvement of local and regional public transport, by using case studies of four countries: Britain (more specifically England, outside London); the Netherlands; Germany; and Sweden. T

Previous research has shown integrated planning to be important for achieving aims concerning more environmentally friendly transport operations, but less good at explaining prerequisites of implementation. This paper analyses how management and working practises in local authorities, here understood as steering cultures, affect implementation of integrated land-use and public transport planning a

Background and aim: Transport planning faces new demands for a dialogue with users. Transport planners no longer just build roads; nowadays they also must listen to users, whose wishes are meant to have an impact on the design and maintenance of the road transport system. Yet how can we know what users really want? This article sets out to analyze the methods with which transport planners gather i

This article analyses how urban authorities manage goals of sustainable development in decentralized planning contexts when faced with economic growth opportunities offered by a powerful development actor. This challenge is described and analysed in a comparative case study of how two Swedish cities handled the issue of new IKEA stores in decision-making and planning. The analysis centres on how p