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Using HTK for Prolonged Pancreas Preservation Prior to Human Islet Isolation

Background. Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to University-of-Wisconsin solution (UWS) for abdominal organ preservation, but data about HTK efficiency to preserve pancreata during prolonged cold ischemia time (CIT) are conflicting. In human islet transplantation, HTK provided similar isolation outcomes after short CIT. The present study aimed to inves

Isotope meteorology of cold front passages: A case study combining observations and modeling

This study investigates the role of below-cloud evaporation and evapotranspiration for the short-term variability of stable isotopes in near-surface water vapor and precipitation associated with central European cold fronts. To this end, a combination of observations with high temporal resolution and numerical sensitivity experiments with the isotope-enabled regional weather prediction model COSMO

Biochar-mediated changes in soil quality and plant growth in a three year field trial

While many laboratory studies have focused on the short term effects of biochar addition to soil), there have been comparatively few tracing its longer term effects in the field. This study investigated the multiyear impact of biochar on crop performance and soil quality with specific emphasis on carbon (C) and nitrogen (N) cycling over a 3 y period. Biochar was added to an agricultural field at 0

Fractures and Alcohol Abuse – Patient Opinion of Alcohol Intervention.

Purpose: To clarify patient opinions about alcohol intervention in relation to surgery before investigating the effect in a Scandinavian multi-centre randomized trial. Material and Methods: A qualitative study. Thirteen consecutive alcohol patients with fractures participated after informed consent. They were interviewed during their hospital stay. The number of participants was based on the crit

Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery.

The mechanisms behind target vs. host cell recognition of the human antimicrobial peptide LL-37 remain ill-defined. Here, we have investigated the membrane disruption capacity of LL-37 using large unilamellar vesicles (LUVs) composed of varying mixtures of POPC, POPG and cholesterol to mimic target and host membranes respectively. We show that LL-37 is unable to induce leakage of entrapped calcein

Still a green leader? The European Union's role in international climate negotiations

Since the early 1990s, the European Union (EU) has presented itself as a leader on climate change. Recently, however, this picture has been challenged in the media and by non-governmental organization representatives. The aim of our article is to evaluate the Union's present role in the area of international climate politics. We do this by scrutinizing the EU's own role conception, but also, and p

Age-specific oxidative status and the expression of pre- and postcopulatory sexually selected traits in male red junglefowl, Gallus gallus

Oxidative stress is emerging as a key factor underpinning life history and the expression of sexually selected traits. Resolving the role of oxidative stress in life history and sexual selection requires a pluralistic approach, which investigates how age affects the relationship between oxidative status (i.e., antioxidants and oxidative damage) and the multiple traits contributing to variation in

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.OBJECTIVE: To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated w

Models and methodology for optimal trajectory generation in safety-critical road–vehicle manoeuvres

There is currently a strongly growing interest in obtaining optimal control solutions for vehicle manoeuvres, both in order to understand optimal vehicle behaviour and, perhaps more importantly, to devise improved safety systems, either by direct deployment of the solutions or by including mimicked driving techniques of professional drivers. However, it is non-trivial to find the right combination

Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.

Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the resp

Maternal Smoking during Pregnancy and Daughters' Preeclampsia Risk.

An obstetrical paradox is that maternal smoking is protective for the development of preeclampsia. However, there are no prior studies investigating the risk of preeclampsia in women who were exposed to tobacco smoking during their own fetal period. We aimed to study the subsequent risk of preeclampsia in women who were exposed to tobacco smoke in utero, using a national population-based register.

Ultrafast Transient Optical Studies of Charge Pair Generation and Recombination in Poly-3-Hexylthiophene(P3ht):[6,6]Phenyl C61 Butyric Methyl Acid Ester (PCBM) Blend Films

Charge generation and recombination are studied in blend films of poly-3-hexylthiophene (P3HT) and [6,6']phenyl C61 butyric acid methyl ester (PCBM) using ultrafast transient absorption spectroscopy. We find that the charge generation yield depends upon both blend film composition and thermal annealing. The data suggest that recombination occurs over a wide range of time scales and that, in the le

Commissioning and Performance of the ATLAS Transition Radiation Tracker with high energy collisions at LHC

The ATLAS Transition Radiation Tracker (TRT) is the outermost of the three sub-systems of the ATLAS Inner Detector at the Large Hadron Collider at CERN. It consists of close to 300,000 thin-wall drift- tubes (straws) providing on average 30 two-dimensional space points for charged particle tracks. The straws have 0.13 mm resolution and measure tracks with vertical bar eta vertical bar < 2 and p(T)

Phenotype and function of intestinal CD103+ dendritic cells

Popular Abstract in Swedish Vårt immunsystem består av ett nätverk av olika sorters celler och molekyler, vars uppgift är att försvara oss mot patogener (sjukdomsalstrande organismer) som till exempel virus och bakterier, medan det samtidigt måste tolerera proteiner och ämnen som finns naturligt i vår kropp. Immunsystemet kan delas upp i två delar; det medfödda (eller ospecifika) och det adaptiva Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. Intestinal dendritic cells (DCs) and macrophages, found throughout the

A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population - the Malmo preventive project study

Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between

Visual acuity in an opportunistic raptor, the chimango caracara (Milvago chimango)

Raptors are always considered to have an extraordinary resolving power of their eyes (high visual acuity). Nevertheless, raptors differ in their diet and foraging tactics, which could lead to large differences in visual acuity. The visual acuity of an opportunist bird of prey, the Chimango caracara (Mivalgo chimango) was estimated by operant conditioning. Three birds were trained to discriminate t