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CenTauR : Toward a universal scale and masks for standardizing tau imaging studies

INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2

Genetic Moderation of the Association of β-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease

Background and Objectives: There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline. The factors explaining this heterogeneity are particularly important for understanding pr

Evaluation of single-fraction high dose FLASH radiotherapy in a cohort of canine oral cancer patients

Background: FLASH radiotherapy (RT) is a novel method for delivering ionizingradiation, which has been shown in preclinical studies to have a normal tissuesparing effect and to maintain anticancer efficacy as compared to conventionalRT. Treatment of head and neck tumors with conventional RT is commonlyassociated with severe toxicity, hence the normal tissue sparing effect of FLASHRT potentially ma

Rethinking bioeconomy innovation in sustainability transitions

Over the past two decades, a new research field dealing with “sustainability transitions” has emerged, analyzing the transformation of socio-technical systems towards more sustainable futures. While there is consensus on the crucial role of the bioeconomy in sustainability transitions research, we argue that the true potential of many bioeconomy innovations is not yet sufficiently recognized and a

Understanding medical aspects of violent crimes in Sweden’s region Skåne: a retrospective cross-sectional design of the ViCS project

Introduction: While there has been a reduction in specific homicide categories in Sweden, the last decade has witnessed an increase in the overall rate. The escalation is predominantly linked to heightened gun violence associated with criminal gangs. As a result, Sweden faces an extreme rate of shootings and firearm-related homicides, constituting one of the most severe instances across Europe. Ho

Guest editorial: Accounting and performance measurement in the age of rankings, quality assurance, accreditation, and excellence frameworks

Over the past three decades, numbers, particularly those that can be expressed in financial terms, have come to be presented as a form of truth. Today, numbers guide and govern us, and shape and influence who we are, or who we should try to become (Kurunmäki et al., 2016). A few decades ago, this quantifying movement was restricted to a few fields. Today, however, it appears as if no one can escap

Peacocks, penknives and power : On the implications of evolutionary psychology for strategic communication

This article conceptualizes evolutionary theory as a bridge between existing theorizing in strategic communication on the one hand, the mind sciences on the other. It discusses six core concepts of evolutionary psychology that have a bearing on strategic communication theory: a) the human as a highly flexible social species; b) the regulation of individually-minded vs. collectively-minded behavior

Mixing in ice covered lakes

Mixing in ice covered lakes is caused by through-flow currents, oscillations of the ice cover and by convective currents induced by heat flow from the sediments or by solar radiation penetrating the ice. Mainly from studies in Swedish lakes, current velocities and mixing coefficients are quantified for the different processes generating water movement. Seiche movement caused by wind induced oscill

KENGEDE MAFIC DYKE SWARM AND EXPANSION OF THE 1.50 Ga KUONAMKA LARGE IGNEOUS PROVINCE OF NORTHERN SIBERIA

Within the Anabar shield in the northern part of the Siberia, Late Precambrian mafic igneous units are widespread, which form dyke swarms of different ages of different trends. This paper presents new data on the composition, structure and U-Pb dating of the E-W trending Kengede dyke swarm. Three new U-Pb ID-TIMS baddeleyite ages (1496±7, 1494±3 and 1494±5 Ma) were obtained from three dykes, indic

Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems

Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo,

A possible 5 km wide impact structure with associated 22 km wide exterior collapse terrain in the Alhabia–Tabernas Basin, southeastern Spain

The Tabernas–Alhabia Basin is a structural depression situated in the province of Almería, southeastern Spain. The basin is filled with Neogene, Pliocene, and Pleistocene sediments resting discordantly on a Paleozoic metamorphic basement. During the marine Tortonian sedimentation, a bed of breccia (Gordo megabed) was formed. It consists of rotated sedimentary megablocks commonly capped and/or surr

Characterisation and analysis of the surface texture of injection-moulded automotive interior ABS and PP components

Interior automotive plastic components are often manufactured by injection moulding since this technique enables cost-efficient manufacturing, large design freedom, and easy integration of functions. However, to obtain a high-quality impression, it is important to produce components with uniformity in texture, colour, and gloss. Unfortunately, this is rather difficult since a large number of mater