Glutamate decarboxylase autoantibodies (GAD65Ab) and β-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21 32 (66%) insulin-treated patients (mean age 43, range 16-79 years) had GAD65Ab; all GAD65Ab persisted 3 years later. At onset, 20 82 (24%) non-insulin-treated patients (mean age 56, range 20-79 years) had GAD65Ab. Of thos

Most autoimmune diabetes occurs in those without a diabetic relative, but few cases are identifiable prospectively. To model general population prediction, 491 consecutive newly diabetic children from all of Sweden were tested for autoantibodies to glutamate decarboxylase (GAD65ab), insulin (IAA), and islet cells (ICA), and for HLA-DQ genotypes by PCR; 415 matched control children were tested in p

Patients with adult-onset Type 1 (insulin-dependent) diabetes mellitus (IDDM) are more difficult to identify than young patients, as their clinical onset is often less acute with a questionable state of insulin dependency. Classification may be facilitated by the detection of autoantibodies that are associated with IDDM. The prevalence of islet cell autoantibodies (ICA) and insulin autoantibodies

Glutamic acid decarboxylase antibodies (GAD65Ab) are common in new onset Caucasian insulin-dependent diabetic (IDDM) patients but it is unclear if this marker is also prevalent in patients of other ethnic backgrounds. We determined antibodies against human recombinant GAD in Japanese diabetic patients using a radioimmunoassay with competition between in vitro translated 35S-GAD65 and non-labelled

The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p

A study of 109 Swedish patients and 85 healthy Swedish controls with Crohn's disease (CD) by HLA class II RFLP genotyping was carried out. There was no significant association for any single DR or DQ specificity or phenotypic combination of DR and/or DO specificities among our study group of Caucasian extraction.

Den statliga förvaltningen i dess olika skepnader har sedan länge mycket stor betydelse för samhället och enskilda i de nordiska länderna. En central fråga i offentlig rätt och statsvetenskap är hur förvaltningens ställning i samhället ska förstås. I ett offentligrättsligt perspektiv handlar det då bland annat om förvaltningens konstitutionella eller statsrättsliga roll. Hur fastställs de rättslig

We report on the straightforward metal-free synthesis of poly(p-terphenyl perfluorophenylsulfonic acid)s by efficient superacid catalyzed Friedel–Crafts polycondensations of commercially available perfluoroacetophenone and p-terphenyl, followed by sulfonation of the pendant pentafluorophenyl groups via a selective and quantitative thiolation-oxidation procedure. The stiff and well-defined polymer

Delegationen för senior arbetskraft har i uppdrag att verka för ett mer inkluderande och åldersoberoende synsätt i arbetslivet. Delegationen ska sammanställa och sprida kunskap om forskning om äldres möjligheter och även föreslå åtgärder som motverkar åldersdiskriminering för att bättre tillvarata senior erfarenhet. Som en viktig del av arbetet med uppdraget har delegationen valt att ta fram en se

Introduction: Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear. Methods: This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessnes

Given the increasingly polarized debates in many modern democracies over migration and integration, the behaviour of members of parliament (MPs) with a migrant background has important implications for patterns of representation. Drawing on role congruity theory, we hypothesize that MPs with a migrant background deliver more legislative speeches in debates that are of interest for citizens with a

The digital twin is a rather new industrial control and automation systems concept. While the approach so far has gained interest mainly due to capabilities to make advanced simulations and optimizations, recently the possibilities for enhanced security have got attention within the research community. In this paper, we discuss how a digital twin replication model and corresponding security archit

A charging infrastructure of electric vehicles is important in order to make the transition from fossil fuels to electricity. There are multiple charging methods, one of which is to use an Electric Road System (ERS)as a static charger. The connection between an ERS and a vehicle is automatic and gives an advantage over other systems which require a human to connect a plug. The focus of the study p

Autonomous machines are in the near future likely to increasingly interact with humans, and carry out their functions outside controlled settings. Both of these developments increase the requirements of machines to be trustworthy to humans. In this work, we argue that machines may also benefit from being able to explicitly build or withdraw trust with specific humans. The latter is relevant in sit

Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs)increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. In this article, a Multi-Agent model depicting long distance transport i

Body weight has been shown to be a predictor of clinical progression in Huntington's disease (HD). Alongside widespread neuronal pathology, both HD patients and the R6/2 mouse model of HD exhibit weight loss and increased energy expenditure, providing a rationale for targeting whole-body energy metabolism in HD. Leptin-deficient mice display low energy expenditure and increased body weight. We the

Pancreatic islets rich in beta-cells were isolated from non-inbred ob/ob-mice and used for studying various aspects of the function of the plasma membrane. A review is given of the authors' work along the following lines: the role of transmembrane transport or membrane binding in the recognition of insulin-releasing sugars, amino acids, sulfonylureas, and sulphydryl-blocking agents; the role of cy