Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique strong adhesion and internalization properties towards DC. These properties were mediated by interaction of the GlcNAc(beta1

Popular Abstract in Swedish Spel och spelbräden har fått lite uppmärksamhet av forskare som undersöker de antika kulturerna. Denna avhandling samlar och analyserar arkeologiskt spelmaterial från bronsålderns Kreta, definierar forskningsfältet och presenterar ett ramverk med materialavgränsningar och typologier. Vidare undersöks spelandet som en del av socialhistorien. Varje del i avhandlingen - soThe old, world-wide phenomenon of playing board games has received little attention among scholars studying the ancient cultures. This thesis collects and analyses game-related material from Bronze Age Crete, defines the field of research and provides a framework with definitions and typologies. A further goal is to use the results of the analyses to extend beyond the archaeological material and e

When planning new environments, such as homes and workplaces, for the physically disabled it is important to encourage active participation from all those involved. In a research programme initiated at the Lund Institute of Technology, Sweden, a new planning method is being introduced which utilizes computer-aided design as a planning tool. This tool supports and activates the understanding and pa

This chapter critically examines the role of networked advocacy groups in the policy making process of intellectual property rights reform. Through analysing the case of la Quadrature du Net, we question the assumption that political intermediaries or elites are dissappearing, leaving space for a more inclusive, direct democracy in which decision-makers interact more directly with citizens. Next t

The state-of-art of reliability studies in the area of fire-exposed structures or structural members is illustrated, taking examples from published papers concerning load-bearing building structures of steel, reinforced concrete, and wood. In parallel, trends are described in the present development of rational structural fire design methods, principally adapted to modern loading and safety philos

Energy conservation is a large part of the NLO corrections to BFKL. A formalism is presented which includes effects of energy-momentum conservation in the dipole formalism in transverse coordinate space. Energy conservation gives a very strong suppression at small x, which implies that the effect of multi-pomeron exchange and saturation are pushed to very small x-values or very high energies. Pert

The increasing semiconductor functionality relies on more complex integrated circuits with higher component densities. Miniaturisation and its implications on resource consumption in semiconductor facilities have been fairly well explored in a number of life cycle assessment (LCA) studies, which show that, in spite of the growing product complexity, resource intensities per product unit are gradua

Diabetic retinopathy is the most common cause of blindness in the Western world in people aged 65 years or less. Intensive blood glucose control reduces the risk for development and progression of retinopathy. There is also a strong association between hypertension and retinopathy, and antihypertensive treatment seems to reduce the risk for both development and progression of retinopathy. The reti

Popular Abstract in Swedish Människans immunsystem utgörs av en komplex sammansättning av celler och molekyler, som interagerar med varandra men även med kroppens övriga vävnader. Dess huvudsakliga uppgift är att förse sin värd med ett försvar mot yttre och inre förhållanden, som kan orsaka denna skada, t.ex. bakterie- och virusinfektioner eller betingelser för utveckling av cancer. Denna försvarsThis thesis is based upon four original papers in which human dendritic cells (DCs) and B cells have been analyzed in terms of how they influence the character of adaptive immune responses. DCs isolated from human tonsils were found to possess a capacity to directly regulate proliferation, isotype switching, and antibody production in B cells. DC-produced cytokines, including IL-13, were identifie

There is a growing interest on Open Source Enterprise Resource Planning (OS-ERP) systems among organizations today. When developing ERP systems a major problem is requirements management. Proponents of open source development often claim it has a high level of involvement from users in adopting organizations. However, comparing with proprietary ERP development it is not that clear if users are mor

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