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The interfaces of innovation in mathematics and the arts.

Emmer (1993) claimed creativity to be a bridge between art and mathematics exemplified (www. olats.org/colloque/textes/texte7.shtml) in his traveling exhibition The Eye of Horus: Art and Mathematics (Emmer, 1990). A shared language is needed to make bridges between science, art and metaphysics (Thiessen, 1998). Scientific phenomena and concepts need to be possible to isolate for better understandi

Genome-Based Sexing Provides Clues about Behavior and Social Structure in the Woolly Mammoth

While present-day taxa are valuable proxies for understanding the biology of extinct species, it is also crucial to examine physical remains in order to obtain a more comprehensive view of their behavior, social structure, and life histories [1, 2]. For example, information on demographic parameters such as age distribution and sex ratios in fossil assemblages can be used to accurately infer socio

Hollow Direct Air Cooled Rotor Windings: Experimental Verification

This paper presents the experimental verification of a cooling concept based on hollow direct air cooling windings for the rotor of an electrically excited synchronous machine (EESM) with the application of traction drive for electric vehicles (EVs). Developing the performance of EESMs is important for the EV industry since it is today so reliant on permanent magnets. The idea behind the cooling c

Development of a multiplex PCR for detection of Fusobacterium necrophorum, Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis

Streptococcus pyogenes, or group A streptococci (GAS) is a well known agent of pharyngitis. The same goes for the closely related S. dysgalactiae subspecies equisimilis (SDSE). Recent data indicates that a third pathogen called Fusobacterium necrophorum, with similarly severe complications to GAS is the second most common pathogen in pharyngitis. These infections cause the greatest damage in low

Labelling of Voltage Gated Sodium Channels

DNA Encoded Library (DEL) screening has emerged as a transformative technology in pharmaceutical research, enabling the high-throughput screening of billions of compounds. While DEL screening has been successful in identifying small molecule ligands for various protein targets, challenges remain in targeting specific classes of proteins, such as membrane proteins, which are challenging to purify a

Examining the surgical backlog due to COVID-19 in Latin America and the Caribbean : insights from a scoping review

This scoping review assessed the surgical backlog in Latin America and the Caribbean (LAC) due to COVID-19 and identified mitigation strategies. We searched seven databases for citations from December 2019 to December 2022, focusing on LAC patients with cancelled or postponed procedures. We registered our protocol at Open Science Framework (https://osf.io/x2nd8) and adhered to PRISMA-ScR guideline

Population genomics of the muskox' resilience in the near absence of genetic variation

Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox (Ovibos moschatus), an

“It Reminds Me Not to Trust China” The Influence of Foreign Conflicts on Taiwanese National Identity

This study investigates the influence of the crackdown on democracy in Hong Kong and the Russian invasion of Ukraine on Taiwanese identity building and the approach to cross strait relations among young Taiwanese adults. The study builds on eight in-depth semi-structured interviews with young Taiwanese adults between the age of 25-35. It utilizes constructivist theory of identity building and surv

Development and Optimization of a Silica Column-Based Extraction Protocol for Ancient DNA

Rapid and cost-effective retrieval of endogenous DNA from ancient specimens remains a limiting factor in palaeogenomic research. Many methods have been developed to increase ancient DNA yield, but modifications to existing protocols are often based on personal experience rather than systematic testing. Here, we present a new silica column-based extraction protocol, where optimizations were tested

A convection-diffusion-reaction system with discontinuous flux modelling biofilm growth in slow sand filters

A Slow Sand Filter (SSF) consists of biofilm attached to saturated packed sand with supernatant water on top, through which water flows by gravity. SSFs are used in the production of drinking water to improve water quality and remove pathogens, and, as they use biological filtration via the microbes present in the biofilm, they are simple and cheap to construct. A drawback of SSFs is that the diff

High genetic diversity and low differentiation reflect the ecological versatility of the African leopard

Large carnivores are generally sensitive to ecosystem changes because their specialized diet and position at the top of the trophic pyramid is associated with small population sizes. Accordingly, low genetic diversity at the whole-genome level has been reported for all big cat species, including the widely distributed leopard. However, all previous whole-genome analyses of leopards are based on th

Million-year-old DNA sheds light on the genomic history of mammoths

Temporal genomic data hold great potential for studying evolutionary processes such as speciation. However, sampling across speciation events would, in many cases, require genomic time series that stretch well back into the Early Pleistocene subepoch. Although theoretical models suggest that DNA should survive on this timescale1, the oldest genomic data recovered so far are from a horse specimen d

Deciphering New Neurocircuitries to Modulate Appetite

Food for Thought, or Thought for Food? Obesity affects 12 % of adults worldwide (GBD 2015 Obesity Collaborators, 2017). This number is only expected to increase in the future. Serious risks are associated with obesity such as heart disease, high blood pressure, and type two diabetes (Pantalone et al., 2017). There are not currently effective and safe methods to aid weight loss (Ruban et al., 2019

Potential involvement of t-circles in the Alternative Lengthening of Telomeres in Naumovozyma castellii

Merry Go Round: Rolling-circle telomere elongation Imagine a shoelace. At the end of the shoelace, there is a protective piece called an aglet, keeping the fibers together. A human chromosome is a bit like that, too – long and linear, with a characteristic structure at the end called the telomere, which protects the chromosome from instability. With each cell division, a piece of the telomeric

Catalytic conversion of CO2 and lignin into valuable chemicals

Increasing concern regarding climate change and environmental sustainability have driven research regarding the development of innovative solutions for CO₂ mitigation and biomass utilization. This thesis explores the catalytic conversion of CO₂ and lignin into valuable chemicals, as a promising approach to achieving carbon neutrality and enhancing the circular economy. The study focused on two key

The Effect of Cartilage Oligomeric Matrix Protein on Anti-Tumor Immune System

Kroppens goda och onda sida i cancer Alla är familiära med sjudomen cancer, antignen via en bekant, vetskap om sjukdomen eller personligt. Trots att det är en relativt vanlig sjudom betyder inte det att kroppen inte har ett försvar mot cancern, vi har faktiskt vårt immunförsvar. Några av de viktiga celler vi har som skydd är våra T-celler, en del av våra vita blodkroppar. Dock, kan kroppen också

Rhythmic parameters and lateralisation in the percussive behaviour of Japanese Macaques (Macaca fuscata)

Japanese macaques (Macaca fuscata) exhibit a suite of stone handling behaviours (SHB, e.g. rolling, pounding, etc.) that lack an obvious instrumental function. As SHBs appear to be socially transmitted, previous research has focused on evolutionary theories of tool use and cumulative culture. It has been assumed that SHBs in general represent a form of solitary play whose function is to hone and m

Medication strategies in first episode psychosis patients : A survey among psychiatrists

Aim: There is an ongoing debate regarding the optimal timing of discontinuation of antipsychotic drugs for patients with first episode psychosis. Although most guidelines recommend maintenance therapy for at least 1 or 2 years after reaching remission, study results indicate that early discontinuation may be beneficial for at least a subsample of patients. To date, little is known about which medi