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Dynamic effects on cutting forces with highly positive versus highly negative cutting edge geometries

Understanding the influence of the cutting edge geometry on the development of cutting forces during the milling process is of high importance in order to predict the mechanical loads on the cutting edge as well as the dynamic behavior on the milling tool. The work conducted in this study involves the force development over the entire engagement of a flute in milling, from peak force during the en

Digital Recruitment and Acceptance of a Stepwise Model to Prevent Chronic Disease in the Danish Primary Care Sector : Cross-Sectional Study

BACKGROUND: During recent years, stepwise approaches to health checks have been advanced as an alternative to general health checks. In 2013, we set up the Early Detection and Prevention project (Tidlig Opsporing og Forebyggelse, TOF) to develop a stepwise approach aimed at patients at high or moderate risk of a chronic disease. A novel feature was the use of a personal digital mailbox for recruit

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

Background: Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Here we studied, for the first time, effects of sex on DNA methylation and gene expression in primary human myoblasts (activated satellite cells) before and after differentiation int

Nanoscale quantum calorimetry with electronic temperature fluctuations

Motivated by the recent development of fast and ultrasensitive thermometry in nanoscale systems, we investigate quantum calorimetric detection of individual heat pulses in the sub-meV energy range. We propose a hybrid superconducting injector-calorimeter setup, with the energy of injected pulses carried by tunneling electrons. It is shown that the superconductor constitutes a versatile injector, w

Being acknowledged by others and bracketing negative thoughts and feelings : Frail older people’s narrations of how existential loneliness is eased

Aims and objectives: The aim of this study was to describe how EL was eased, as narrated by frail older people. Background: Existential loneliness (EL) is an unavoidable part of the human condition. It is a complex phenomenon that has been described as disconnection from life. If EL is acknowledged in the care of older people, the experience of EL can be reduced. Design: In this qualitative study,

Follow-up on: optimizing lesion detection in small bowel capsule endoscopy and beyond: from present problems to future solutions

Introduction: This review presents noteworthy advances in clinical and experimental Capsule Endoscopy (CE), focusing on the progress that has been reported over the last 5 years since our previous review on the subject. Areas covered: This study presents the commercially available CE platforms, as well as the advances made in optimizing the diagnostic capabilities of CE. The latter includes recent

Using microworlds to study critical infrastructure protection—the effect of incentives on risk management

A computer simulated microworld was used to study risk management in a critical infrastructure context. 36 students assumed the role of an electric distribution company Chief Executive Officer (CEO) making decision on how to spend resources between investments in risk reduction and other investments. We studied the effect of differences in terms of the incentives to invest in risk reduction and th

GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration

Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these negative outcomes is that the clinical trials were done in late-stage patients that have advanced nigrostriatal degeneration and may therefore not re

Testing the vertical and cyber-physical integration of cognitive robots in manufacturing

In recent years, cognitive robots have started to find their way into manufacturing halls. However, the full potential of these robots can only be exploited through (a) an integration of the robots with the Manufacturing Execution System (MES), (b) a new and simpler way of programming based on robot skills, automated task planning, and knowledge modeling, and (c) enabling the robots to function in

Residual stresses in high speed turning of nickel-based superalloy

Residual stresses induced by machining operations can be critical for the performance and lifetime of the machined components. Tis paper investigated the influence of cutting conditions, including the use of cutting fluid, cutting speed and tool flank wear, on the residual stresses in high speed turning of Inconel 718 alloy. X-ray diffraction measurements revealed characteristic residual stress di

Family resilience in immigrants’ entrepreneurial opportunity creation process

This paper adopts an inductive case study to examine the role of family resilience in the immigrants’ opportunity creation process. We employ family resilience (Walsh, 2002) and the opportunity creation process (Alvarez and Barney, 2007). We conducted an inductive case study on four cases of immigrant entrepreneurs who established businesses in Sweden and who have their origins in Lebanon and Syri

Family and neighborhood socioeconomic inequality in cryptorchidism and hypospadias : A nationwide study from Sweden

Objectives: To examine whether there is an association between neighborhood deprivation and incidence of cryptorchidism and hypospadias, after accounting for family-level and individual-level sociodemographic characteristics. Methods: All boys born in Sweden between January 1, 2001 and December 31, 2010 were followed. Data were analyzed by multilevel logistic regression, with family-level and indi

A Centre for Teaching and Learning ”Moving in from the Margins”

Background: Faculty development roles are changing within organizations (Gibbs 2013). In previous research the expanding role in organizations as “Coming in from the margins” was described (Schroeder 2011). We studied how different levels of participation evolved within a research intense faculty with a complex organization and various educational programs.Summary of Work: The Centre was establish

Femtosecond-laser electronic-excitation tagging velocimetry using a 267 nm laser

Femtosecond (fs)-laser electronic-excitation tagging velocimetry (FLEET) in a nitrogen flow field using a 267 nm laser was performed under the condition of fs-laser filamentation. The filamentous properties and their effects on velocity measurements were investigated and were compared with those of an 800 nm fs-laser. The results show that the required energy of the 267 nm laser pulse is as low as