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Thermometric analysis of blood metabolites in ICU patients

Real-time monitoring of patient’s blood metabolites, such as glucose and lactate, could potentially improve surgery and recovery outcomes for patients in surgical and intensive care units. Our enzyme thermometric biosensor which is based on flow injected calorimetric determination of immobilized enzyme reaction is capable of performing continuous, fast, and quantitative analysis of metabolites usi

Autoimmunity plays a role in the onset of diabetes after 40 years of age

Aims/hypothesis: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of a

On the political feasibility of climate change mitigation pathways : Is it too late to keep warming below 1.5°C?

Keeping global warming below 1.5°C is technically possible but is it politically feasible? Understanding political feasibility requires answering three questions: (a) “Feasibility of what?,” (b) “Feasibility when and where?,” and (c) “Feasibility for whom?.” In relation to the 1.5°C target, these questions translate into (a) identifying specific actions comprising the 1.5°C pathways; (b) assessing

Many-body calculations of two-photon, two-color matrix elements for attosecond delays

We present calculations for attosecond atomic delays in the photoionization of noble-gas atoms based on the full two-color two-photon random-phase approximation with exchange in both the length and velocity gauge. Gauge-invariant atomic delays are demonstrated for the complete set of diagrams. The results are used to investigate the validity of the common assumption that the measured atomic delays

Comparison of outcomes in infected cardiovascular implantable electronic devices between complete, partial, and failed lead removal : an ESC-EHRA-EORP ELECTRa (European Lead Extraction ConTrolled) registry

AIMS: The present study sought to determine predictors for success and outcomes of patients who underwent cardiac implantable electronic devices (CIED) extraction indicated for systemic or local CIED related infection in particular where complete lead removal could not be achieved.METHODS AND RESULTS: ESC-EORP ELECTRa (European Lead Extraction ConTRolled Registry) is a European prospective lead ex

The Role of Complement in Transfusion-Related Acute Lung Injury

Transfusion-related acute lung injury (TRALI) is a life-threatening complication of acute respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells appear to be important for p

Measurement of W± boson production in Pb+Pb collisions at √sNN=5.02Te with the ATLAS detector

A measurement of W± boson production in Pb+Pb collisions at sNN=5.02Te is reported using data recorded by the ATLAS experiment at the LHC in 2015, corresponding to a total integrated luminosity of 0.49nb-1. The W± bosons are reconstructed in the electron or muon leptonic decay channels. Production yields of leptonically decaying W± bosons, normalised by the total number of minimum-bias events and

Measurement of W± -boson and Z-boson production cross-sections in pp collisions at √s=2.76 TeV with the ATLAS detector

The production cross-sections for W± and Z bosons are measured using ATLAS data corresponding to an integrated luminosity of 4.0 pb- 1 collected at a centre-of-mass energy s=2.76 TeV. The decay channels W→ ℓν and Z→ ℓℓ are used, where ℓ can be an electron or a muon. The cross-sections are presented for a fiducial region defined by the detector acceptance and are also extrapolated to the full phase

Antibodies against neo-epitope of microbial and human transglutaminase complexes as biomarkers of childhood celiac disease

Tissue transglutaminase (tTG) and microbial transglutaminase (mTG) cross-link gliadins to form complexes that expose immunogenic neo-epitopes to produce tTG and mTG-neo-epitope antibodies. The aim of this study was to test the diagnostic performance of antibodies against non-complexed and complexed forms of transglutaminases, to correlate their activities to the intestinal damage and to explore ag

Evidence for prejunctional GABAB receptors mediating inhibition of ovarian follicle contraction induced by nerve stimulation

The motor effects of gamma-aminobutyric acid (GABA) on the bovine ovarian follicle were studied in vitro using strips from follicle walls. Electrical field stimulation of nerves in the preparation, secured by tetrodotoxin blockade, caused a contraction that was almost totally abolished by phentolamine and only slightly affected by atropine. This mainly adrenergic neurogenic response was inhibited

Alteration by histamine of the sympathetic nerve-mediated contractions in the bovine ovarian follicle wall in vitro

The histaminergic effect on electrically induced contractions and tritium release was studied in vitro, using strips from the wall of mature bovine ovarian follicles. Follicular fluid and blood plasma from the animals were analysed for electrolyte, bicarbonate, glucose and total protein concentrations in order to compare them with the concentrations of these components in the Krebs-Ringer solution

QCD matter with a crossover and a first-order phase transition

We present a phenomenological parametrization of the phase diagram of QCD as a function of temperature T and baryochemical potential µ. The parametrization is constructed by introducing a switching function which controls the nature of the transition between the Hadron-Resonance Gas (HRG) and Quark-Gluon Plasma (QGP) phases of nuclear matter, such that the equation of state (EOS) possesses a rapid

Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk

Genome-wide association studies (GWAS) have identified 45 susceptibility loci associated with lung cancer. Only less than SNPs, small insertions and deletions (INDELs) are the second most abundant genetic polymorphisms in the human genome. INDELs are highly associated with multiple human diseases, including lung cancer. However, limited studies with large-scale samples have been available to syste