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In vivo knee kinematics during gait reveals new rotation profiles and smaller translations

In order to identify abnormal or pathological motions associated with clinically relevant questions such as injury mechanisms or factors leading to joint degeneration, it is essential to determine the range of normal tibiofemoral motion of the healthy knee. In this study we measured in vivo 3D tibiofemoral motion of the knee during gait and characterized the nonsagittal plane rotations and transla

Isoindigo-based aza-BODIPY small molecule for N-type organic field-effect transistors

To date, most of the reported conjugated materials are p-type semiconductors, while the advances in n-type or ambipolar conjugated materials greatly fall behind those in p-type counterparts. Well-defined n-type semiconductors should possess suitable electron-deficient groups and relatively low lowest unoccupied molecular orbitals (LUMO) levels that facilitate the electron injection and stabilize t

Auditory brainstem responses in tinnitus : A review of who, how, and what?

The auditory brainstem response (ABR) in tinnitus subjects has been extensively investigated over the last decade with the hopes of finding possible abnormalities related to the pathology. Despite this effort, the use of the ABR for tinnitus diagnosis or as an outcome measure is under debate. The present study reviewed published literature on ABR and tinnitus. The authors searched PubMed, MedLine,

The tumor promoter cysteinyl leukotriene receptor 1 regulates PD-L1 expression in colon cancer cells via the Wnt/β-catenin signaling axis

Immunotherapy targeting programmed death-ligand 1 (PD-L1) or PD-1 in solid tumors has been shown to be clinically beneficial. However, in colorectal cancer (CRC), only a subset of patients benefit from PD-1/PD-L1 treatment. Previously, we showed that high cysteinyl leukotriene receptor 1 (CysLT1R) levels are associated with poor prognosis in CRC patients. Recently, we have revealed the role of the

Accelerating a car from rest : friction, power and forces

The directions of frictional forces for bodies in motion are conceptually challenging. Students may be able to provide a correct solution using only calculus without drawing free-body diagrams. This can make their misconceptions go unnoticed and put them at risk to become further reinforced. Here, we discuss first-year bachelor students’ responses to multiple-choice questions and an open-ended que

Lead-free cesium titanium bromide double perovskite nanocrystals

Double perovskites are a promising family of lead-free materials that not only replace lead but also enable new optoelectronic applications beyond photovoltaics. Recently, a titanium (Ti)-based vacancy-ordered double perovskite, Cs2 TiBr6, has been reported as an example of truly sustainable and earth-abundant perovskite with controversial results in terms of photoluminescence and environmental st

‘We do what we can with what we have’ - The daily life of people with disabilities and the long and complicated road to improve it in Pando Bolivia

In the search for grasping how the everyday life experience for people with a disability is shaped in relation to the local social and political complexities in Cobija/Pando four themes are crucial to understand. Firstly, illustrating how the rhetorical definition of disability removes the wrongfulness or responsibility from the shoulders of the individual to an exclusive social environment. Even

It's no longer just an ebb and flow, it's a constant

Det här är ett arbetet som rör sig i gränsland. Det berör platsen där sociologi och psykologi möts, och utforskar därifrån gränsen som löper mellan normalitet och abnormalitet. I fokus står borderline personlighetssyndrom, en psykiatrisk diagnos som karaktäriseras av instabilitet i affekt, relationer och identitet. Diagnosen diskuteras här huvudsakligen utifrån en teori om att problematiken huvuds

Tuning halide perovskite energy levels

The ability to control the energy levels in semiconductors is compelling for optoelectronic applications. In this study, we managed to tune the work function (WF) of halide perovskite semiconductors using self-assembled monolayers of small molecules to induce stable dipoles at the surface. The direction and intensity of the surface dipoles rely on specific molecule-to-surface interactions. Electro

The tenets of quantile-based inference in Bayesian models

Bayesian inference can be extended to probability distributions defined in terms of their inverse distribution function, i.e. their quantile function. This applies to both prior and likelihood. Quantile-based likelihood is useful in models with sampling distributions which lack an explicit probability density function. Quantile-based prior allows for flexible distributions to express expert knowle

Contrasting effects of wooded and herbaceous semi-natural habitats on supporting wild bee diversity

The use of pesticides and the lack of resources caused by the simplification of landscapes are often cited as the main drivers of the loss of wild bees. Landscape complexity has been shown to interact with local pesticide use in studies of the effect of these factors on the abundance and diversity of insects. But, to date, few studies have simultaneously investigated local and landscape effects on

Virtuosos of Mimesis and Mimicry : a Case Study of Movements Propagating Conspiracy Theories in Ireland and Poland

In recent years, conspiracy theories have been increasingly defined as a new social enemy, a threat to democracy. But scholars of conspiracy theories also point out that we have very little research that examines a direct link between conspiracy theories and political practice. We still know very little about the ways in which conspiratorial beliefs influence different forms of civic engagement an

Stable eye versus mouth preference in a live speech-processing task

Looking at the mouth region is thought to be a useful strategy for speech-perception tasks. The tendency to look at the eyes versus the mouth of another person during speech processing has thus far mainly been studied using screen-based paradigms. In this study, we estimated the eye-mouth-index (EMI) of 38 adult participants in a live setting. Participants were seated across the table from an expe

Deep learning volumetric brain segmentation based on spectral CT

The purpose of this pilot study was to evaluate if a deep learning network can be used for brain segmentation of grey and white matter using spectral computed tomography (CT) images. Spectral CT has the advantage of a lower noise level and an increased soft tissue contrast, compared to conventional CT, which should make it better suited for segmentation tasks. Being able to do volumetric assessmen

Naphthodipyrrolopyrrole-based Aza-BODIPY dye for N-type organic field-effect transistors

To date, n-type semiconductor designs are less investigated than their p-type counterparts, due to the fact that the charge transport mobility and the stability of the n-type materials are generally lower than those of the p-type ones. Well-defined n-type semiconductors often require low lowest unoccupied molecular orbital (LUMO) levels that facilitate the electron injection from the electrode int

Sex differences in muscle activation patterns associated with anterior cruciate ligament injury during landing and cutting tasks : A systematic review

Neuromuscular control is critical for maintaining dynamic joint stability and mitigating the risk of anterior cruciate ligament (ACL) injury. Given the increased risk of ACL injury in females, sex-based differential muscle activation strategies are often associated with this risk. For example, the quadriceps-dominant muscle activation strategy sometimes observed in females has been discussed as a

The clinical significance of electromyography normalisation techniques in subjects with anterior cruciate ligament injury during treadmill walking

This study investigated the clinical interpretation of three electromyographic (EMG) normalisation techniques to detect neuromuscular alterations in patients diagnosed with anterior cruciate ligament knee injury during treadmill walking. The EMG signal was normalised using the mean value during the gait cycles (MEA), the maximum value during the gait cycles (MAX), and a maximum voluntary isometric

Centrosome Movements Are TUBG1-Dependent

The centrosome of mammalian cells is in constant movement and its motion plays a part in cell differentiation and cell division. The purpose of this study was to establish the involvement of the TUBG meshwork in centrosomal motility. In live cells, we used a monomeric red-fluorescenceprotein-tagged centrin 2 gene and a green-fluorescence-protein-tagged TUBG1 gene for labeling the centrosome and th