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One of the largest challenges of computational chemistry is calculation of accurate free energies for the binding of a small molecule to a biological macromolecule, which has immense implications in drug development. It is well-known that standard molecular-mechanics force fields used in most such calculations have a limited accuracy. Therefore, there has been a great interest in improving the est
Substrate pH has been shown to be important for bryophyte distribution, although bryophytes are believed to obtain more or less all of their nutrients from rain water and deposition of airborn dust. In order to better understand bryophyte-pH relations we investigated pH ranges of bryophytes and bryophyte richness at different pH in southern Sweden. In addition, species turnover and critical pH val
Capacitive binding assays have long been considered highly sensitive. The underlying method in such assays includes sending short potential pulses and then registering the current. However, with the introduction of current pulses and registration of potential responses, the stability improved significantly, leading to assays of extreme sensitivities. The new assaying technology has been applied in
Opportunities for online shopping are transforming travel behaviour related to shopping, and they have the potential to reduce overall travel demands. This paper analyses the potential for reductions in carbon dioxide (CO2) emissions from passenger transport due to an increased use of online shopping in Sweden and adds to the broader picture of what potential growing online shopping might have on
Objective To provide clinical clues to differential diagnosis in patients with chorea and other movement disorders with blood acanthocytes. Methods We present a long-term video accompanied follow-up of six Caucasian patients with neuroacanthocytosis from several centers, three diagnosed with chorea-acanthocytosis (ChAc): 34-y.o.(no.1), 36-y.o.(no.2), 43-y.o.(no.3), two diagnosed with McLeod Syndro
We introduce a general decomposition method applicable to all forms of bivariate rank dependent indices of socioeconomic inequality in health, including the concentration index. The technique is based on recentered influence function regression and requires only the application of OLS to a transformed variable with similar interpretation. Our method requires few identifying assumptions to yield va
The 6th Haemophilia Global Summit was held in Prague, Czech Republic, in September 2015. The programme was designed by an independent Scientific Steering Committee of haemophilia experts and aimed to share optimal management strategies for haemophilia at all life stages, explore recent potential advances in the management of haemophilia A and B and discuss challenges in haemophilia care. In this s
Recent scholarship in IR has increasingly focused on the “global transformation” of the 19th century. Many of the defining features of modern IR first emerged in the 19th century, among them a new group of actors – international organisations. Yet the intergovernmental organisations (IGO) of the late 19th and early 20th century were not identical to the IGOs of the post-1945 period. 19th century I
The paper explores perceptions during the early 20th century regarding the required and desired underpinnings of a post-imperial India—i.e. one in which both British India and the indirectly ruled Princely States were first, by the British, proposed and then, through the work of the Indian Constituent Assembly, made to constitute a federation. At the heart of the paper resides a query regarding In
Conceptually, this paper is about make-believe states and how such state is a socially constructed space, imagined and performed by those who perceive themselves as belonging to that state. It asks through what imaginaries and performative practices does a state come into being? Make-believe is here employed as an analytical category to refer both to the work of the imagination and to the material
Aujourd’hui, le Secrétaire général des Nations unies joue un rôle essentiel en matière de diplomatie préventive et de sensibilisation aux problématiques d’envergure mondiale. Pourtant, la Charte des Nations unies le présente simplement comme « le plus haut fonctionnaire de l’Organisation ». Comment en est-il venu à jouir d’une telle autonomie sur la scène politique internationale ? En quoi le prem
The aim of this thesis is to make it simple and efficient to produce applications for smartphones. The main area of application is within the health care sector, where alarm receiving devices are needed to inform personnel of pending situations. Most medical alarm systems are unique and hence require a unique GUI (Graphical User Interface). However, at the core, the main functionality is to commun
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy in those at risk, despite an increasing understanding of the underlying molecular and cellular pathways. One of the major factors that have impeded rap
Rationale: A microdeletion at locus 15q13.3 is associated with high incidence rates of psychopathology, including schizophrenia. A mouse model of the 15q13.3 microdeletion syndrome has been generated (Df[h15q13]/+) with translational utility for modelling schizophrenia-like pathology. Among other deficits, schizophrenia is characterised by dysfunctions in prefrontal cortical (PFC) inhibitory circu
Purpose: Many centers aim to plan liver transarterial radioembolization (TARE) with dosimetry, even without CT-based attenuation correction (AC), or with unoptimized scatter correction (SC) methods. This work investigates the impact of presence vs absence of such corrections, and limited spatial resolution, on 3D dosimetry for TARE. Methods: Three voxelized phantoms were derived from CT images of
Reviews of evidence are a vital means of summarising growing bodies of research. Systematic reviews (SRs) aim to reduce bias and increase reliability when summarising high priority and controversial topics. Similar to SRs, systematic maps (SMs) were developed in social sciences to reliably catalogue evidence on a specific subject. Rather than providing answers to specific questions of impacts, SMs
Soot concentration measurements were performed using diode-laser extinction in an atmospheric air-blown entrained flow gasifier at two vertical levels. The gasifier was operated at different air-fuel equivalence ratios and with variations in fuel and burner configurations. Two fuels were investigated: wood powder and peat powder. These were burned using two burner configurations, one giving a rota
