The prevalence of type 2 diabetes (T2D) is increasing worldwide, but current treatments have limitations. miRNAs may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D is associated with altered expression and DNA methylation of miRNAs using adipose tissue from 14 monozygotic twin pairs discordant for T2D. Four members each of the miR-30

Emotions have traditionally been considered the enemy of reason in Social Science. However, emotions can both enhance and hinder learning in Social Science. It is therefore important to reflect upon why and how emotions play a role, rather than shutting the emotions out or leaving them unreflected in the teaching. This paper draws on ethnographic data from Social Science teaching in four Swedish u

Aim: Studies have suggested that there is a difference in risk of local recurrence(LR) with circumferential resection margins (CRM) less than 1.0 mm. We aimed toexamine how exact resection margins affect LR risk.Method: Data from the Swedish Colorectal Cancer Registry (SCRCR) were usedfor retrospective analysis of resected rectal cancers between 2005 and 2013. Primaryendpoint was LR.Results: 12146

BackgroundTo explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines.MethodsIn this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisin-6 gene was performed using 3'/5' RACE PCR. The quantitative RT-PCR used to study t

Organisms must cope with different risk/reward landscapes in their ecological niche. Hence, species have evolved behavior and cognitive processes to optimally balance approach and avoidance. Navigation through space, including taking detours, appears also to be an essential element of consciousness. Such processes allow organisms to negotiate predation risk and natural geometry that obstruct forag

Industrialization and globalization processes in Vietnam have resulted in increased marketization of care, which is imbued with ideological goals that capitalize upon and invigorate gendered morality. Morality thus provides a helpful analytical entry for my exploration of the ways in which feminized ethics of care is informed by moral codes and values for appreciated and condemned behavior in wome

This article tells a story of the aftermath of the ‘failed revolution’ in Egypt through the prism of sound and gendered political prisoner bodies. It created embodied re-actions among Cairene men—years after their lived prison experiences—in which depression, sorrow, stress, paranoia, rage, or painful body memories are prevalent. Affect theory shows how sonic vibrations—important stimuli within ev

This report describes how the work has been conducted in the project “A National Strategy for Standardisation of Digital Information Management within the BuiltEnvironment” (further on denoted NSS). This report describes the project background, aim, objective, methodology, schedule, organisation, and identified areas and processes that have been the basis for the development of the initial three-y

The title aldehydes (lr, 1s, 2, and 3) underwent virtually diastereospecific conjugate addition by lithium methylcyanocuprate. The bulkiness of the anomeric benzyloxy or methoxy groups direct the attacking nucleophile to the less hindered side of the furanosidic ring. The stereochemical outcome of the Diels-Alder additions of cyclopentadiene to lr and 1s was governed almost completely by the bulki

Phytic acid treated with Baker's yeast gave D-myo-inositol-1,2,6-tris(phosphate) (α-trinositol) which was transformed into (+)-D-1,2-O-isopropylidene-myo-inositol and (-)-D-4,5-tri- O-benzyl-myo-inositol, two key intermediates in the synthesis of optically active myo-inositol derivatives and related compounds.

The reaction of perbenzylated (±)-myo-inositol 1,2-bis- and 1,2,6-tris-phosphites with benzyl bromoacetate, followed by catalytic (Pd/C) hydrogenolysis affords (±)-myo-inositol 1,2-bis- and 1,2,6-tris(carboxymethylphosphonate). The same procedure is used for the synthesis methyl α-D-mannopyranoside 2,3,4-tris(carboxymethylphosphonate).

Language and different sexual health discourses constitute barriers to the uptake of information on sexual and reproductive health and rights among migrants. Challenges remain with regards to the design and implementation of culturally appropriate programmes and interventions. This study explored the role of civic communicators in increasing access to sexual health information among migrants reset

Benzylidene protected bis-MPA, 2,2-bis(hydroxymethyl)propanoic acid, was synthesised and evaluated as building block in the construction of dendrimers. It was found that the anhydride of benzylidene protected bis-MPA reacts with neopentylic alcohols to give high yields of acylated products. Purification is facilitated by the crystalline nature of most ester products. Deprotection by hydrogenolysis