Short fatigue cracks are known to have a growth behaviour different from that of long cracks, the latter well predicted by linear elastic fracture mechanics. Short cracks can grow at high rates at load levels well below the threshold value for long cracks, before entering into the long crack region, or arrest and become nonpropagating cracks. The growth behaviour of short cracks is strongly influe

Skiljeförfarandet är en privat alternativ tvistlösningsmetod, med syfte att snabbt och slutligt avgöra tvister utan insyn utifrån. Från den utgångspunkten är det viktigt att skiljeförfarandet inte följs av en långdragen och offentlig domstolsprocess. Skiljedomar kan därmed inte överprövas på materiella grunder. För att skiljeförfarandet ska vara ett rättssäkert och godtagbart alternativ till domstThe arbitration procedure is a private alternative dispute resolution method aimed at quickly and definitively resolving disputes without external oversight. From this perspective, it is important that the arbitration is not followed by a prolonged and public court process. Arbitral awards, therefore, cannot be appealed on substantive grounds. However, for the arbitration to be a legally secure an

The traditional management of acute coronary syndrome has relied on the identification of ST-segment elevation myocardial infarction (STEMI) as a proxy of acute coronary occlusion. This conflation of STEMI with acute coronary occlusion has historically overshadowed non-ST-segment elevation myocardial infarction (NSTEMI), despite evidence suggesting 25% to 34% of NSTEMI cases may also include acute

This study has explored school counselors' experiences of their professional role in working with mental health issues among adolescents aged 12-19 in Skåne, Sweden. Using a qualitative method based on semi-structured interviews, the study investigated the challenges encountered by seven selected school counselors in their daily practice. The interviews have been conducted at the school counse

The recent popularity of audiobooks has led to new ways of using the format as publishers and producers reproduce and “reactualise” older works by adapting them into audio. The article examines this development, focusing on the case of Storytel’s 2022 audio adaptation of George Orwell’s 1984 and the marketing campaign surrounding it, combining a publishing studies approach (Squires 2007; Murray 20

Studiens fokus ligger i att undersöka unga kvinnors medvetenhet kring användningen av deepfakes inom pornografi samt hur unga kvinnor och deras beteende på sociala medier påverkas av fenomenet. Studien utfördes med en kvantitativ metod i form av en webbenkät samt en kvalitativ metod i form av fem intervjuer. Till skillnad från tidigare forskning ämnar studien att förstå kvinnors agerande på socialThe phenomenon deepfake was created in 2017 and has since developed and received a lot of attention, especially in pornography thus the absolute majority of all deepfakes on the internet are of pornographic content, with 90% of those who are exposed to deepfakes are woman. The purpose of this essay is to investigate young women’s awareness of deepfakes as well as how the phenomenon used in porn co

It is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to catalyze the turnover of multiple, chemically distinct substrates, plays a key role in the evolution of new enzyme functions. In this context, the members of the alkaline phosphatase superfamily have been extensively studied as model systems in order to understand the phenomenon of enzyme multifuncti

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for the first time, that DNA epigenetic modifications change the molecule's dynamical landscape, increasi

In recent years, it has become increasingly clear that many enzymes are catalytically "promiscuous". This can provide a springboard for protein evolution, allowing enzymes to acquire novel functionality without compromising their native activities. We present here a detailed study of Pseudomonas aeruginosa arylsulfatase (PAS), which catalyzes the hydrolysis of a number of chemically distinct subst

The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research,

Aims: To estimate the proportion eligible for lipid-lowering therapy (LLT) when using the systemic coronary risk estimation 2 (SCORE2) on apparently healthy individuals. Methods and results: Individuals aged 50-64 years were randomly invited to The Swedish Cardiopulmonary Bioimage Study (n = 30 154). Participants with previous atherosclerotic cardiovascular disease (CVD), diabetes mellitus, or chr

Objective: Around 30% of people with schizophrenia are refractory to antipsychotic treatment (treatment-resistant schizophrenia). Abnormal structural neuroimaging findings, in particular volume and thickness reductions, are often described in schizophrenia. Novel biomarkers of active brain pathology such as neurofilament light chain protein are now expected to improve current understanding of psyc

Objective: Stress-related mental health problems (MHP) are increasing worldwide. It has been shown that people with stress-related MHP may benefit from nature-based interventions (NBI), and equine-assisted therapy (EAT) to support their health, recovery, and activity level of daily life. However, the evidence-base to support this is still weak and there is a knowledge gap concerning health-, recov

Dagens textilindustri är starkt präglad av fast fashion, en global industri som bygger på stora inköp och små marginaler vilket leder till en överproduktion där 40 procent av de textilier som tillverkas globalt aldrig kommer ut på marknaden. Detta resulterar i bristande arbets- och levnadsförhållanden i produktionsländer samt enorma utsläpp. Med hjälp av politiska incitament och teknologiska framsToday's textile industry is strongly characterized by fast fashion, a global industry based on large purchases and small margins, leading to overproduction where 4 percent of the textiles produced globally never reach the market. This results in poor working and living conditions in producing countries and huge emissions. With policy incentives and technological advances, we can move towards l

A study about differences between swedes an non swedes and how a non swede can claim a place in Sweden and feel safe.