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Mantle cell lymphoma (MCL) remains a challenging and generally incurable disease. We aimed to evaluate survival trends in advanced-stage MCL over the past three decades, focusing on the impact of evolving first-line therapies. We pooled six randomized phase III trials of treatment-naïve, advanced-stage MCL patients enrolled between 1996 and 2020. Patients were grouped into four eras by enrollment
Over the last twenty years, an exciting interplay has emerged between proof systems and algorithms. Some natural families of algorithms can be viewed as a generic translation from a proof that a solution exists into an algorithm for finding the solution itself. This connection has perhaps been the most consequential in the context of semi-algebraic proof systems and basic primitives in algorithm d
The internet has undergone a profound transformation, evolving from an academic-military experiment into the dominant infrastructure of the platform-based Web 2.0, and is now potentially transitioning toward a decentralized Web3. While this evolution is often portrayed as a primarily technical process, this chapter emphasizes the importance of understanding the socio-political and institutional co
Non-technical summary. How the media talks about climate issues shapes public understanding of these issues. This article explores the news media debate about aviation and climate change in the US between 2016 and 2020. It finds that news coverage focused mostly on industry-led solutions, such as new technology and carbon offsetting. By contrast, reducing demand for flying was given little attenti
Perovskite oxides are a versatile class of materials with tunable electronic structures, making them attractive for catalytic applications, including the oxygen evolution reaction (OER). The surface reactivity of these oxides is closely tied to the electronic structure of transition metal cations, particularly their 3d orbital occupation, which can be modulated by interfacial engineering. In this
Background and aims: Drought weakens tree defenses, predisposing Norway spruce (Picea abies) to spruce bark beetle (Ips typographus) attack. The extreme 2018 summer drought in Sweden triggered an unprecedented bark beetle outbreak. Our objective was to quantify how weather, soil moisture, and tree provenance influence Norway spruce defense capacity to a necrotrophic beetle-associated pathogen. Met
Small modular reactors (SMRs) are increasingly promoted as part of future fossil-free energy systems, yet they may introduce new types of risks and involve a broader set of actors compared to conventional nuclear power plants. The study examines how key actors in Sweden understand SMRs and interpret their roles in radiation emergency preparedness. This qualitative study is based on qualitative int
Background: Early ambulation is a cornerstone of enhanced recovery after surgery (ERAS) programs, reducing pulmonary and thromboembolic complications. Gynecologic oncology patients are at particular risk, yet factors of delayed ambulation remain underexplored. Using objective monitoring from a real-time locating system (RTLS), this study examined patient and procedural predictors of delayed ambula
Nonwoven fibre networks underpin filtration, insulation and geotextiles, where liquid uptake, redistribution and release govern performance. In needle-punched felts, barbed needles mechanically entangle fibres and partially reorient them towards the thickness direction (z), creating out-of-plane “pillars” and heterogeneity. While mechanical and structural consequences of needling are well document
AIM: To assess the efficacy of deprescribing blood pressure-lowering medications in hypertensive patients suffering from severe hypotensive syncope.METHOD: Multicentre, prospective, pragmatic, non-randomized uncontrolled, study. Deprescribing (withdrawal or dose reduction of antihypertensive and psychoactive medications with blood pressure lowering effects) was guided by clinical experience and su
Background: The prognostic significance of myocardial infarction with non-obstructive coronary arteries (MINOCA) in older adults remains uncertain, particularly in comparison with revascularized acute coronary syndromes (ACS) and other acute myocardial injury phenotypes. Methods: In the prospective population-based cohort of the Malmö Diet and Cancer Study (n = 30,466), 925 participants who exp
Is the future of digitalisation autonomous machines, or will humans retain a critical role? If we want to maintain the ability of the system to adapt before, during and afterevents, we need to take advantage of the strengths of people and technology as a human-machine system, say Rogier Woltjer and Tom Laursen.KEY POINTSƒ Recognising the interaction and interdependence between humans and technolog
This article examines how many of Sweden’s most successful global companies have remained rooted in their home regions rather than relocating to Stockholm. By creating local networks of suppliers, skilled workers, research institutions, and public services, these firms have helped sustain dynamic regional economies. The Swedish experience raises important questions for Korea, where economic activi
Battery-swapping technology addresses key limitations of electrified agricultural machinery: battery energy density and efficient energy replenishment. This paper integrates an optimization algorithm for dispatchable battery-swapping into an electric farming simulation framework. A three-year simulation compares the optimized strategy, which leverages batteries for both field operations and energy
Retaining glycosyltransferases catalyze the formation of stereochemically conserved glycosidic bonds through mechanisms that remain debated. Using bovine α1,3-galactosyltransferase (α3GalT) as a model, we combine mutagenesis, equilibrium unfolding, kinetics, and molecular dynamics simulations to understand how donor-induced loop ordering promotes catalysis. Alanine-scanning mutagenesis of the C-te
Evidence is inconclusive on whether immigrants are at higher risk of substance use disorders compared to non-immigrants. We investigated the risk of drug and alcohol use disorder (DUD and AUD) in first- and second-generation immigrants with refugee and non-refugee backgrounds using the nationwide Swedish longitudinal healthcare and legal registers. We included 798 141 males and 756 903 females who
