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Neutral microprotein, a novel human plasma and urinary protein associated with a yellow-brown chromophore. Isolation from protein HC preparations and partial characterization

An apparently novel human plasma and urinary protein of low molecular weight was isolated from several highly purified preparations of protein HC by gel chromatography and high voltage electrophoresis with a yield of about 8 mg/g. The protein has a molecular weight of about 20,000, neutral electrophoretic mobility at pH 6.5 and a high content of half-cystine. It is associated with a yellow-brown c

Occurrence of gamma-trace in the calcitonin-producing C-cells of simian thyroid gland and human medullary thyroid carcinoma

gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a mo

The complete amino acid sequence of human complex-forming glycoprotein heterogeneous in charge (protein HC) from one individual

The complete amino acid sequence of the single polypeptide chain of human complex-forming glycoprotein heterogeneous in charge (protein HC) isolated from a single individual is reported with the supporting data. The primary structure was determined by automatic degradation of the intact chain and of fragments obtained by chemical and enzymatic degradations of the native or reduced and S-carboxymet

Sustainabilty and retail marketing : Corporate, product and store perspectives

This paper investigates sustainability in retailing based on three different perspectives: i) the overall corporate management, ii) the development of an attractive product range, iii) the daily in-store management and activities. The purpose is to identify a set of main themes for each perspective, investigate contradictions and areas of conflict, and discuss how to bridge the perspectives. A qua

FE analysis on the association between tool edge radius and thermal-mechanical load in machining Inconel 718

The cutting edge geometry has a significant influence on thermal-mechanical loads and the quality of machined surface in machining operations. In this study, a joint numerical and experimental investigation was conducted to study the effects of tool edge radius on process variables (tool temperatures, force components, stresses) and process dynamics in orthogonal machining Inconel 718. The numeric

Analyzing the Environmental Consequences of Production Processes from a System of Systems Perspective : A Case of Gear Manufacturing in the Automotive Industry

Many research studies have been done to investigate different aspects of environmental challenges. In the product development context, there have been attempts to reduce the environmental impacts of associated activities including the production processes themselves. As a result, various technological improvements have been made and new production processes e.g. powder metallurgy technologies have

Comparing acquisition and operation life cycle costs of powder metallurgy and conventional wrought steel gear manufacturing techniques

The automotive industry has striven for fuel economy and resource efficiency through the deployment of powder metallurgy (PM) manufacturing processes for few decades. However, PM technology for transmission gears is currently only used at a small scale within the automotive industry. This is mainly due to: its shortcomings in material properties and performance gaps for final parts; lack of advanc

CPR a general Cost Performance Ratio in Manufacturing - A KPI for judgement of different technologies and development scenarios

Several parameters and variables affect the production cost and the company competitiveness. The manufacturing part cost is directly influenced by factors related to tools, workpiece materials, equipment, personnel, automation, etc. These factors also have a significant influence on the manufacturing efficiency and performance. The presented model determines the production performance with respectSeveral parameters and variables affect the production cost and the company competitiveness. The manufacturing part cost is directly influenced by factors related to tools, workpiece materials, equipment, personnel, automation, etc. These factors also have a significant influence on the manufacturing efficiency and performance. The presented model determines the production performance with respect

Simulation of nanometric cutting using molecular dynamics

The aim of this work is to perform molecular dynamic simulations of nanometric cutting on single crystal copper with a diamond tool in orderto investigate the dependence of crystallographic orientation and cutting speeds on the cutting forces, machined surface and temperature. It wasfound that the temperature in the substrate, locally and globally, increased for increasing velocity. A higher degre

Determining process parameters for successful material reclamation of lead-free brass chips using hot forging operations: Lubrication

When small and hollow components are being manufactured, it is not uncommon that a majority of the workpiece material is removed by machining. A demand for parts made with lead-free brass alloys can potentially increase the manufacturing cost and therefore it is necessary to investigate ways to increase the material utilization. As part of a more resource efficient production, a method for reusing

Dosimetric and Clinical Predictors for Acute and Late Gastrointestinal Toxicity Following Chemoradiotherapy of Locally Advanced Anal Cancer

Aims: To analyse dosimetric and clinical predictors for acute and late gastrointestinal toxicity following chemoradiotherapy of anal cancer. Materials and methods: Consecutive patients with locally advanced (T2 ≥4 cm – T4 or N+) anal cancer were selected from an institutional database (n = 114). All received intensity-modulated radiotherapy with concomitant 5-fluorouracil and mitomycin C. Gastroin

Multi-objective testing of different brass alloy components for DFM

This paper investigates the differences of leaded and low-lead brasses in terms of mechanical and thermal properties, machinability and product strength using physical testing and simulations. The information can be used in companies for Design for Manufacturability (DFM) while designing processes for lead free brass. The novelty of this research is to combine data from different testing methods t

Functional recovery of the germ line following splicing collapse

Splicing introns from precursor-messenger RNA (pre-mRNA) transcripts is essential for translating functional proteins. Here, we report that the previously uncharacterized Caenorhabditis elegans protein MOG-7 acts as a pre-mRNA splicing factor. Depleting MOG-7 from the C. elegans germ line causes intron retention in most germline-expressed genes, impeding the germ cell cycle, and causing defects in

Syndecan receptors : pericellular regulators in development and inflammatory disease

The syndecans are the major family of transmembrane proteoglycans,usually bearing multiple heparan sulfate chains. They are present onvirtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in bothvertebrates and invertebrates have shown that syndecans link to the actincytoskeleton and can fine-tune cell adhesion

Analytical and Experimental Determination of the Ra Surface Roughness during Turning

In this article an analytical equation for calculating the theoretical arithmetic mean surface roughness, Ra, in the case of turning using a tool with a circular nose radius is presented. The deviation that often occurs between the expected and the obtained surface roughness during these machining operations is investigated. Influence of the minimum chip thickness is discussed especially in regard

Syndecans in Inflammation at a Glance

Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small molecules, proteinases, and other extracellular matrix proteins to initiate downstream signaling pathways. Syndecans play a major role in inflamm

Glycan Mimetics from Natural Products : New Therapeutic Opportunities for Neurodegenerative Disease

Neurodegenerative diseases (NDs) affect millions of people worldwide. Characterized by the functional loss and death of neurons, NDs lead to symptoms (dementia and seizures) that affect the daily lives of patients. In spite of extensive research into NDs, the number of approved drugs for their treatment remains limited. There is therefore an urgent need to develop new approaches for the preve

Quantitative analysis of chip segmentation in machining using an automated image processing method

Analysis of chip formation is one of the most established and informative methods for description of the cutting process. A number of established techniques ranging from optical to electron microscopy have been developed for analysis of continuous chips. Yet, machining of difficult-to-cut materials is accompanied by segmented chip formation. This paper presents an original algorithm based on image

Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous Tre-2/Bub2/CDC16 (TBC) Rab GTPase-activating proteins