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Purpose: The aim of this study was to establish a valid national cohort of patients diagnosed with acromegaly by combining data from the general National Patient Register (NPR) and the disease-specific Swedish Pituitary Register (SPR). Methods: Patients ≥ 18 years of age at diagnosis of acromegaly reported from 1991 to 2018 who were registered in the NPR and/or SPR were included. The diagnosis of

I kapitlet diskuteras sambandet mellan estetiska regler och kvalitet i ett arkitektursammanhang. Utgångspunkt är fallstudier hämtade från den amerikanska stadbyggnadsrörelsen New Urbanism och den teori som jag utvecklade i min avhandling "Seaside, Windsor och Celebration". Viktiga huvudbegrepp är stabil och spontan kvalitet, vilka står för kvalitet som är hög/god tack vare rådande normer, respekti

International development cooperation is undergoing a transformation, driven by the urgent need for more effective, holistic approaches to address enduring global challenges. This thesis explores the paradigmatic shift towards complex adaptive systems (CAS) thinking in Swedish bilateral development cooperation project management, in response to these challenges. This shift mirrors a broader evolut

Agricultural intensification at field and landscape scales, including increased use of agrochemicals and loss of semi-natural habitats, is a major driver of insect declines and other community changes. Efforts to understand and mitigate these effects have traditionally focused on ecological responses. At the same time, adaptations to pesticide use and habitat fragmentation in both insects and flow

The authors propose a computationally efficient approach to estimate the directions of arrival of far-field sources impinging on a sensor array. The proposed estimator is formed using a sparse reconstruction framework, employing a novel adaptive grid selection technique to reduce the dimensionality of the used dictionary matrix. The method further makes use of a SPICE-inspired dictionary to adapti

Purpose: To investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [18F]flutemetamol and [18F]florbetaben. Methods: Cognitively impaired and unimpaired individuals (N = 250, 36% Aβ-positive) were included and injected with [18F]flutemetamol (N = 175) or [18F]florbetaben (N = 75). PET scans were acquired in list-mode (90–110 min po

In this paper, we investigate a class of braided convolutional codes (BCCs), where the component codes are convolutional self-orthogonal codes (CSOCs), called braided convolutional self-orthogonal codes. Compared to conventional BCCs, the advantages of braided CSOCs include the availability of several low-complexity decoding methods and the relative ease of extending these methods to high rates Mo

Structural deterioration and increasing load demand are two main factors that compromise the serviceability and functioning of civil constructions. The vastity of the bridge portfolio and the few resources available require maintenance optimization to provide the required user safety. In this context, vibration-based monitoring may provide information about the structural performance and support d

Objective: We aimed to test whether region-specific factors, including spatial expression patterns of the tau-encoding gene MAPT and regional levels of amyloid positron emission tomography (PET), enhance connectivity-based modeling of the spatial variability in tau-PET deposition in the Alzheimer disease (AD) spectrum. Methods: We included 685 participants (395 amyloid-positive participants within

Purpose: The primary objective of this research is to determine critical success factors (CSFs) that enable textile enterprises to effectively implement Kaizen, a Japanese concept of continuous development, particularly during disruptive situations. The study aims to provide insights into how Kaizen is specifically employed within the textile sector and to offer guidance for addressing future cris

Background: Growing evidence suggests intergenerational effects of paternal pre-conceptional smoking through the germ line, but its specific impact on offspring semen quality remains uncertain because of challenges in isolating paternal exposure from maternal passive smoking or underreporting. Methods: We reran previous analyses estimating differences in semen parameters and testicular size accord

Som en del av HORIZON EUROPE-projektet AfroSAFE: Säkert system för radikal förbättring av trafiksäkerheten i afrikanska låg- och medelinkomstländer, en översyn av nationella bestämmelser, riktlinjer och procedurer för väginfrastruktursäkerhetshantering (RISM), såväl som vägar. designriktlinjer utfördes i Ghana, Tanzania och Zambia. Information samlades in från relevanta myndigheter och granskningeAs part of the HORIZON EUROPE project AfroSAFE, a review of national regulations, guidelines, and procedures for Road Infrastructure Safety Management (RISM), as well as road design guidelines was carried out in Ghana, Tanzania, and Zambia. Information was collected from relevant authorities and the review had special attention to the safety of vulnerable road users (pedestrians, cyclists, and mot

We compare Holocene tree cover changes in Europe derived from a transient Earth system model simulation (Max Planck Institute Earth System Model - MPI-ESM1.2, including the land surface and dynamic vegetation model JSBACH) with high-spatial-resolution time slice simulations performed in the dynamic vegetation model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) and pollen-based quantita

Purpose: Linked health-care registries and high coverage in Nordic countries lend themselves well to epidemiologic research. Given its relatively high incidence in Western Europe, complexity in diagnosis, and challenges in registration, multiple myeloma (MM) wasselected to compare registries in Denmark, Finland, and Sweden.Patients and Methods: Data were obtained from four archetypal registries in

Pollinators are important drivers of floral trait evolution, yet plant populations are not always perfectly adapted to their pollinators. Such apparent maladaptation may result from conflicting selection through male and female sexual functions in hermaphrodites. We studied sex-specific mating patterns and phenotypic selection on floral traits in Aconitum gymnandrum. After genotyping 1786 offsprin

Innovation and its management in retail organisations is an emerging field, yet the measurement of innovation in this context remains challenging and under-researched. The study investigates innovation in large Swedish retail companies, focusing on monitoring and measurement of innovation performance. Through a qualitative, multiple case study, our findings reveal that retailers are aiming to beco