Osteosarcoma is the most common primary bone malignancy, often detected in children and adolescents and commonly associated with TP53 alterations along with a high number of chromosomal rearrangements. However, osteosarcoma can affect patients of any age, and some tumors display less genetic complexity. Besides TP53 variants, data on key driving mutations are lacking for many osteosarcomas, partic

I denna artikel ställs frågan om inte den lojalitetsplikt, som utmejslats allt tydligare på senare tid genom HD:s praxis och som dessutom blir starkare i tider av kris, tillsammans med 36 § avtalslagens oskälighetsstandard vid ändrade förhållanden, idag kan leda till slutsatsen att det (åtminstone i kristider) föreligger en omförhandlingsskyldighet – vad som skulle kunna kallas ansvar för culpa in

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.

Background: The application of a bioresorbable calcium sulfate/hydroxyapatite (CaS/HA) ceramic at the interface of fenestrated screws and osteoporotic bone significantly enhances the immediate mechanical anchorage compared with non-augmented controls. However, the anchoring effectiveness of different screw augmentation techniques in spines with varying vertebral bone mineral density (BMD) remains

Piezoelectric actuators embedded in compliant structures have many potential applications, which call for effective design approaches. Existing optimization driven design methods focus on the piezoelectric actuator location or the macro topology of the host compliant structure while ignoring the possibility to exploit the use of multiple materials and hierarchical material design. In this study, a

Background: Human breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit (TDLU). This structure is endowed with its very own lobular fibroblasts representing one out of two steady-state fibroblast subtypes—the other being interlobular fibroblasts. While cancer-associated fibroblasts (CAFs) are increasingly appreciated as co

The discovery of collective effects in small collision systems has spurred a renewed interest in hadronization models, and is also a source for collective effects all the way to large collision systems, where they are usually ascribed to the creation of a Quark–Gluon Plasma. In this topical mini-review, the microscopic model for string interactions, based on the Lund string hadronization model, de

John L. Schellenberg has suggested that we should guide the evolution of religion towards the goal of discovering the truth about transcendent reality. I argue that we need some way of discerning progress if this project is to be practically feasible. I explore what discernible progress would require in some possible future scenarios. Focus lies on scenarios involving improved cognitive contact wi

Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaini

We report on the precise radial velocity follow-up of TOI-544 (HD 290498),ã bright K star ( V = 10.8), which hostsã small transiting planet recently disco v ered by the Trãnsiting Exoplanet Survey Satellite (TESS) . We collected 122 high-resolution High Accuracy Radial velocity Planet Searcher (HARPS)ãnd HARPS-N spectra to spectroscopically confirm the transiting planetãnd measure its mass. The ne

Investigation of the dynamics of colloids in bulk can be hindered by issues such as multiple scattering and sample opacity. These challenges are exacerbated when dealing with inorganic materials. In this study, we employed a model system of Akaganeite colloidal rods to assess three leading dynamics measurement techniques: 3D-(depolarized) dynamic light scattering (3D-(D)DLS), polarized-differentia

This work investigates the impact of pilot flame and fuel composition on the structures and stabilization of swirling turbulent premixed methane/hydrogen/air flames in a lab-scale gas turbine model combustor. Simultaneous measurements of the velocity field and OH radicals distribution in the combustor were conducted using particle imaging velocimetry (PIV) and planar laser-induced fluorescence (PL

Globally we are facing a complex web of grand challenges that are impacting the lived environment, our development pathways, and wider quality of life. Urban environments serve as a key context around which these grand challenges are not only experienced while also providing multiple opportunities to reduce environmental impacts and resource consumption; improve health outcomes; eradicate poverty;

Avhandlingen är en sammanläggning av fyra artiklar om universell utformning i praktiken. Att designa för alla människor är en vägledande princip som Sveriges riksdag och regering beslutat om som del av implementeringen av FN:s konvention om rättigheter för personer med funktionsnedsättning. Avhandlingen bidrar med kunskap om förståelse, genomförande och samskapande gällande universell utformning. The thesis is a compilation of four articles and deals with Universal design in practice. This concept for designing for all is according to the Swedish Parliament and Government a guiding principle for the society. It is part of the implementation of the UN Convention on the Rights of Persons with Disabilities. The thesis contributes with knowledge about the understanding, implementation and co-c

To complete a new Swedish railway line in a much shorter timeframe than today, alter natives to the traditional methods need to be explored. One option is the use of prefabricated concrete slabs elevated on piers, analogous to the concept used in China for building new railways in record time (He et al., 2017). The method has the advantage of directly tackling the barrier effects exhibited by trad

Across the world, so-called warlord democrats (WDs) – former military or political leaders of armed groups who subsequently enter formal electoral politics – strongly influence the dynamics and trajectory of post-civil war politics. However, scholarship on war-to-peace transitions and post-conflict politics have often failed to pay attention to the agency of these important actors. This article re

Denna studie undersöker hur äldreboenden presenterade sina verksamheter på Instagram under covid-19-pandemins första år, genom kvalitativ analys av fyra intervjuer med företrädare för äldreboenden, samt 1748 bilder från två Instagramkonton.Resultatet visar att medan boendenas företrädare i intervjuerna beskrev år 2020 som kaosartat, presenterades livet på äldreboendena på Instagram som aktivt och