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Startups use prototyping to develop and validate their products and business models. For startups, it is important to have a good knowledge of relevant adoption factors, to make decisions regarding which prototyping technology to adopt. In this article, we identify such factors based on our practical experiences of startups in various industries. We define a research framework, describe challenges
Precipitation is intrinsically associated with high uncertainty, which is exacerbated exponentially over time—especially concerning climate change. However, the current design practice in urban drainage infrastructure remains firmly bound to deterministic assumptions regarding the design load. This approach is too simplified—focusing only on the return period of the design event—and ignores the co
Erving Goffman’s book Frame Analysis (1974) differs from several of his other texts (e.g. the praised books The Presentation of Self in Everyday Life, Encounters, Stigma and Asylums) in that it is probably read because of Goffman’s reputation rather than because it is considered to have an indispensable message. Frame Analysis doesn’t seem to be a book that you must read. It lacks the heuristic ch
Frequency division duplex (FDD) massive multiple-input multiple-output (MIMO) systems introduce a large overhead in downlink channel estimation in contrast to the time division duplex (TDD) mode. This overhead results in a considerable spectral efficiency (SE) gap between the FDD and TDD modes. In this paper, we consider the performance of the TDD and FDD massive MIMO systems with a spatially corr
Bifidobacterium longum endo-α-N-acetylgalactosaminidase (GH101), EngBF, is highly specific toward the mucin Core 1 glycan, Galβ1-3GalNAc. Apart from the side chains involved in the retaining mechanism of EngBF, Asp-682 is important for the activity. In the crystal structures of both EngBF and EngSP (from Streptococcus pneumoniae), we identified a conserved water molecule in proximity to Asp-682 an
Measuring the redshift of active galactic nuclei (AGNs) requires the use of time-consuming and expensive spectroscopic analysis. However, obtaining redshift measurements of AGNs is crucial as it can enable AGN population studies, provide insight into the star formation rate, the luminosity function, and the density rate evolution. Hence, there is a requirement for alternative redshift measurement
Increased wealth and per capita energy use have transformed lives and shaped societies, but energy poverty remains a global challenge. Previous research has shown positive relationships among metrics of health and happiness and economic indices such as income and gross domestic product and between energy use and human development. To our knowledge, however, no comprehensive assessment has examined
Traditionally, election polls have asked for participants' own voting intentions. In four elections, we previously found that we could improve predictions by asking participants how they thought their social circles would vote. A potential concern is that the social-circle question might predict results less well in elections with larger numbers of political options because it becomes harder to ac
In recent decades, the Barents Sea has warmed more than twice as fast as the rest of the Arctic in winter, but the exact causes behind this amplified warming remain unclear. In this study, we quantify the wintertime Barents Sea warming (BSW, for near-surface air temperature) with an average linear trend of 1.74 °C decade-1 and an interdecadal change around 2003 based on a surface energy budget ana
Objective: Immediate cartilage structural alterations in the acute phase after an anterior cruciate ligament (ACL) rupture may be a precursor to posttraumatic osteoarthritis (PTOA) development. Our aim was to describe changes in cartilage matrix in the subacute phase of the acutely ACL-injured knee compared to the contralateral uninjured knee. Design: Participants (n = 118) aged 15–40 years with a
Purpose: The aim of this study was to develop and validate an artificial intelligence (AI)-based method using convolutional neural networks (CNNs) for the detection of pelvic lymph node metastases in scans obtained using [18F]PSMA-1007 positron emission tomography-computed tomography (PET-CT) from patients with high-risk prostate cancer. The second goal was to make the AI-based method available to
Twenty-three lines from a mutagenized Bangladeshi BARI Gom-25 wheat population that included previously identified salt-tolerant lines, and the BARI Gom-25 control variety, were cultivated in a drip-irrigated salinity test field at Salt Farm Texel, Netherlands, to assess their performance during salt stress in European climatic conditions. Lines were tested at irrigation salinity levels of 1, 4, 8
Several recently published trials investigate novel therapies for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). To estimate the benefit of these therapies in the real-world setting, comprehensive data on patients treated in clinical routine are needed. We report outcomes for 736 R/R DLBCL patients identified among all curatively treated DLBCL patients in Sweden in the period 2007–
Cannabis sativa var. Kompolti, a variety routinely used for food production purposes, is characterized by a low concentration of psychoactive molecules, although containing many other biologically attractive metabolites in all parts of the plant, including the roots. In the present work, we evaluate the specific biological activities of the roots’ extract from plants cultivated through aeroponics,
The total of catalytic particles is often unavailable to participate in the electrochemical reactions in a PEFC, which limits the PEFC performance. The electrochemical surface area (ECSA) becomes an important metric to diagnose the catalyst layer's performance and evaluate the development of new electrode materials to achieve better overall efficiency. This work intends to analyze the effects of a
Maternal smoking during pregnancy constitutes a potential, major risk factor for adult male reproductive function. In the hitherto largest longitudinal cohort, we examined biomarkers of reproductive function according to maternal smoking during the first trimester and investigated whether associations were mitigated by smoking cessation prior to the fetal masculinization programming window. Associ
Introduction: People with haemophilia (PwH) may experience symptoms of haemophilia-related pain, depression or anxiety, which can negatively impact health-related quality of life. Aim: To obtain the perspective of PwH and treaters from Sweden, Finland and Denmark on the management of haemophilia-related pain, depression and anxiety using cross-sectional survey data from the MIND study (NCT03276130
Malaria and helminthic co-infection during pregnancy causes fetomaternal haemorrhage and foetal growth retardation. This study determined the pooled burden of pregnancy malaria and helminthic co-infection in sub-Saharan Africa. CINAHL, EMBASE, Google Scholar, Scopus, PubMed, and Web of Science databases were used to retrieve data from the literature, without restricting language and publication ye
With new developments in sensor technology, a new generation of vehicle dynamics controllers is developing, where the braking and steering strategies use more information, e.g. knowledge of road borders. The basis for vehicle-safety systems is how the forces from tyre–road interaction is vectored to achieve optimal total force and moment on the vehicle. To study this, the concept of attainable for
