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Automated Vibratome Sectioning of Agarose-Embedded Lung Tissue for Multiplex Fluorescence Imaging

Due to its inherent structural fragility, the lung is regarded as one of the more difficult tissues to process for microscopic readouts. To add structural support for sectioning, pieces of lung tissue are commonly embedded in paraffin or OCT compound and cut with a microtome or cryostat, respectively. A more recent technique, known as precision-cut lung slices, adds structural support to fresh lun

Soluble CD163 predicts outcome in both chemoimmunotherapy and targeted therapy–treated mantle cell lymphoma

The outcome for patients with mantle cell lymphoma (MCL) has drastically improved with new treatments directed toward the tumor immune microenvironment, where macrophages play an important role. In MCL, the presence of M2 macrophages defined by CD163 expression in diagnostic biopsies has been associated with a worse prognosis. An alternative way to assess the abundance of M2 macrophages is by meas

Pedestrian/cyclist experience during dark conditions: A conceptual model

Walking and biking are active transport modes, that may be part of sustainable transport chains, thereby reducing car use. In the scientific literature, they have commonly been investigated separately (e.g. Ewing et al., 2006; Kellstedt et al., 2021), but since pedestrians and cyclists often share the same environments, it makes sense to consider them jointly. This research proposes a conceptual m

Cumulative incidence of type 1 diabetes in two cohorts of children with different national gluten recommendations in infancy

Aims: Between 1985 and 1996, Sweden experienced an “epidemic” of celiac disease with a fourfold increase in incidence in young children. Timing and amount of gluten introduced during infancy have been thought to explain this “epidemic”. We aimed to study whether the cumulative incidence of type 1 diabetes differs between children born during the “epidemic” compared to children born after. Methods:

Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation

The dendritic arbour of striatal projection neurons (SPNs) is the primary anatomical site where dopamine and glutamate inputs to the basal ganglia functionally interact to control movement. These dendritic arbourisations undergo atrophic changes in Parkinson's disease. A reduction in the dendritic complexity of SPNs is found also in animal models with severe striatal dopamine denervation. Using 6-

The legal aspects of cruise ship passenger contracts

The purpose of this chapter is to discuss the legal issues relating to cruise ship passenger contracts, their nature and salient features, parties to the contract and their rights and obligations. Claims arising out of passenger carriage subject to applicable law and contracts containing standard terms and conditions are addressed. It is rare for passengers to examine the terms and conditions of t

Incidence of Dermatitis Herpetiformis in Sweden 2005 to 2018 : A Nationwide Retrospective Cohort Study

Dermatitis herpetiformis has been investigated in the past; however, only a limited number of studies have reported its incidence based on validated nationwide population-based registries. To address this gap, the aims of this study are to estimate the incidence of dermatitis herpetiformis in Sweden and to validate the National Patient Register (NPR) for diagnosis of dermatitis herpetiformis. A po

The importance of user involvement : a systematic review of involving older users in technology design

Background and Objectives: There is a lack of understanding of how older adults' involvement and participation matters in actual design practice. This systematic literature review investigates existing empirical studies involving older users during the design of technologies and explores the nature and consequences of involving older people. Research Design and Methods: Our literature review is in

Periodontitis is associated with airflow obstruction in the Malmö Offspring Dental Study

AIM: To investigate the association between periodontitis and lung function in the Malmö Offspring Dental Study.MATERIALS AND METHODS: In all 1001 individuals (49.9% female, mean age: 44.6) from Malmö Offspring Dental Study were included. Periodontitis was assessed by a full-mouth examination protocol including bleeding on probing and classified according to the American Academy of Periodontology/

How Ethnic Discrimination Shapes Political Reintegration After War : Insights from a Conjoint Experiment in Colombia

The reintegration of former armed group affiliates into formal politics is a fundamental challenge for post-conflict societies. Arguably, this challenge is even more difficult in settings where ethnic discrimination is pervasive, since discrimination implies comparatively higher barriers to political reintegration for racialized ex-combatants. In this paper, we explore how ethnicity and armed grou

New Archaeointensity Results from the Iron Age in Southern Africa

Abstract In this study we present new palaeointensity measurements on Iron Age (200 AD – 1840 AD) pottery from the southern Africa region, where there is only limited data available at present. Many sites only produce a single accepted palaeointensity result and we have therefore opted to focus on analysis at sample level as opposed to site level, which is more common in traditional archaeomagneti

Proving gender and sexuality in the (homo)nationalist Greek asylum system : Credibility, sexual citizenship and the ‘bogus’ sexual other

The aim of this article is to analyse and critique Greek authorities’ expectations for a ‘credible’ account in queer asylum claims. As some of the caseworkers’ accounts portray, through 16 semi-structured interviews, in order to be deemed ‘credibly queer’ applicants are expected to have passed through a painful, discursively narratable process of self-realization and have suffered enough in their

Polycrystalline cubic boron nitride material

This disclosure relates to a high cBN content polycrystalline cubic boron nitride, PCBN, material. The binder matrix material comprises 19 to 50 wt.% chromium, or a compound thereof.This disclosure relates to a high cBN content polycrystalline cubic boron nitride, PCBN, material. The binder matrix material comprises 19 to 50 wt. % chromium, or a compound thereof.

Polycrystalline cubic boron nitride material

This disclosure relates to a polycrystalline cubic boron nitride, PCBN, material that includes a binder matrix material containing nitride compounds. The nitride compounds are selected from HfN, VN, and/or NbN.