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Ambitions and obstacles for evidence-based municipal primary healthcare - a mixed- methods study

BackgroundResearch is limited on registered healthcare professionals (RHCP) usage of research and evidence-based practice (EBP) in Swedish municipal primary healthcare work.Aim/ObjectivesThe aim of this study was to increase the understanding of experiences, attitudes, and conditions of usage of research and implementation of EBP among RHCPs in a Swedish municipality setting. Further, the study ai

Carotenoids in fresh and processed tomato (Solanum lycopersicum) fruits protect cells from oxidative stress injury

BACKGROUND: Lipophilic antioxidants in tomato (Solanum lycopersicum) fruits exert important functions in reducing the risk of human diseases. Here the effect of thermal processing on the antioxidant activity of lipophilic extracts from the commercial tomato hybrid ‘Zebrino’ was analysed. Carotenoid content and lipophilic antioxidant activity were determined and the ability of tomato extracts in re

Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites

Aim: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2′ of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt). Materials & methods: Spectroscopic and crystallographic data of the Pt(II)-AFt nanocomposite have been collected and in vitro anticanc

Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivo

HPLC-PDA-MS/MS analysis of Syzygium jambos leaf extract allowed the identification of 17 secondary metabolites, including flavonol glycosides, flavonol di-glycosides, and flavones as well as ellagitannins and phenolic acids. The extract showed promising antioxidant activities in different experimental models. In Caenorhabditis elegans, the extract mediated a dose dependent survival rate and decrea

Protective effect of Opuntia ficus-indica L. cladodes against UVA-induced oxidative stress in normal human keratinocytes

Opuntia ficus-indica L. is known for its beneficial effects on human health, but still little is known on cladodes as a potent source of antioxidants. Here, a direct, economic and safe method was set up to obtain water extracts from Opuntia ficus-indica cladodes rich in antioxidant compounds. When human keratinocytes were pre-treated with the extract before being exposed to UVA radiations, a clear

Five-Coordinate Platinum(II) Compounds Containing Sugar Ligands : Synthesis, Characterization, Cytotoxic Activity, and Interaction with Biological Macromolecules

This article describes the synthesis and characterization of novel cationic five-coordinate Pt(II) complexes containing nitrogen sugar-based ligands. The cytotoxicity of the complexes was evaluated on different cell lines with the expectation that both the coordinative saturation and the sugar moiety cooperate to enhance their biological activity. In fact, the complexes resulted to be more active

Characterization of a surface-active protein extracted from a marine strain of penicillium chrysogenum

Marine microorganisms represent a reservoir of new promising secondary metabolites. Surface-active proteins with good emulsification activity can be isolated from fungal species that inhabit the marine environment and can be promising candidates for different biotechnological applications. In this study a novel surface-active protein, named Sap-Pc, was purified from a marine strain of Penicillium

Anywhere workers and the sustainable development of tourist destinations

Working from anywhere, often associated with digital nomadism, is a growing trend that blurs the boundaries between work and leisure, with individuals choosing to work from tourist destinations. The phenomenon has caught the attention of academics, who mainly focus on the lifestyle aspects of digital nomadism. However, destination management organizations, as well as the tourism and hospitality in

Intake of total cruciferous vegetable and its contents of glucosinolates and isothiocyanates, glutathione S-transferases polymorphisms and breast cancer risk: a case-control study in China

Cruciferous vegetables contain high levels of glucosinolates (GSL) and isothiocyanates (ITC). ITC are known to induce glutathione S-transferases (GST) and thus exert their anticarcinogenic effects. This study explored the combined effects of cruciferous vegetable, GSL and ITC intake and GST polymorphisms on breast cancer risk. A total of 737 breast cancer cases and 756 controls were recruited into

Psychological Flexibility and Daily Functioning in Adults with Systemic Lupus Erythematosus: a Daily Diary Study

Det primära syftet med studien var att undersöka genomförbarheten av dagliga skattningar två gånger dagligen av symtom, psykologisk flexibilitet (PF) och funktion hos vuxna med systemisk lupus erythematosus (SLE). Det sekundära syftet var att undersöka sambandet mellan de vanligaste och mest besvärande symtomen på SLE (dvs. smärta, trötthet, ångest, depression och kognitiv påverkan), hälsorelateraThe primary aim of this study was to assess the feasibility of obtaining twice-daily recordings of symptoms, psychological flexibility (PF) and functioning from adults with Systemic Lupus Erythematosus (SLE). The secondary aim was to investigate the relationship between the most common and burdensome symptoms of SLE (i.e., pain, fatigue, anxiety, depression and cognitive impairment – CI), health r

Kan ett vinklat narrativ påverka minnesbilden? En kvantitativ studie om framing-effekt

Denna studie syftade till hur framing-effekten påverkar minnesbilder och individers uppfattningar om en våldsam händelse, med fokus på ordningsvakters agerande. I en kvantitativ experimentell design fördelades försökspersonerna (n=63) slumpmässigt i två grupper, kontrollgrupp (n=30) och experimentell grupp (n=33). Experimentgruppen exponerades för ett negativt vinklat narrativ och kontrollgruppen The aim of this study was to investigate the influence of the framing effect on individuals’ perceptions and memory of a violent event, focusing specifically on the actions of security guards. In a quantitative experimental design, the participants (n=63) were assigned either a neutral (n=30) or a biased narrative (n=33) before watching a video of a group conflict. Participants were then asked to

Investigating Sensor-based Condensation Detection in Network Cameras using Psychrometry

The presence of fog, or condensation, poses significant challenges in various fields, including surveillance cameras. The main issue is that fog obstructs the camera's view, essentially rendering the camera ineffective for surveillance. Currently, preventative measures such as heating the camera are a remedy at the cost of significantly increased power consumption. This master’s thesis is aime

Finns det en relation mellan arbetsklimat och en individs självförmåga och självmedkänsla?

Denna studies syfte var att undersöka huruvida det fanns en relation mellan arbetsklimatet och arbetstagarens självförmåga och självmedkänsla. Även eventuella skillnader mellan nivån av dessa variabler baserat på hur länge respondenterna varit på sin arbetsplats undersöktes. Undersökningen genomfördes genom en enkät där 130 deltagare (68 kvinnor, 62 män) fick självskatta arbetsklimat, självförmågaThe purpose of this study was to investigate whether there was a relationship between the work climate and employees’ self-efficacy and self-compassion. Also, possible differences between the level of these variables, based on how long the respondents had been at their workplace, were investigated. The study was conducted through a survey where 130 participants (68 women, 62 men) were asked to sel

Plundering the Skilled Workforce : Depriving Developing Nations of Their Most Valuable Assets

Whether developed or less developed, all countries need skilled mental labor (SML) to use technologies effectively and to attain economic growth and development. Without appropriate SML, no country can make the best use of its firms and institutions. Time and investment are required for an individual to become a skilled mental laborer, but these are not sufficient. The training must be at a level

International cross-sectional survey on current and updated definitions of intra-abdominal hypertension and abdominal compartment syndrome

Background: The Abdominal Compartment Society (WSACS) established consensus definitions and recommendations for the management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in 2006, and they were last updated in 2013. The WSACS conducted an international survey between 2022 and 2023 to seek the agreement of healthcare practitioners (HCPs) worldwide on current and n

Short- and long-term effects of beta-blockers on symptoms of anxiety and depression in patients with myocardial infarction and preserved left ventricular function : a pre-specified quality of life sub-study from the REDUCE-AMI trial

Aims: Among patients with myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF), the REDUCE-AMI trial did not demonstrate a benefit of beta-blocker vs. no beta-blocker treatment on all-cause mortality and recurrent myocardial infarction. The aim of this pre-specified sub-study was to investigate effects of beta-blockers on self-reported symptoms of anxiety and depress

Echocardiographic Grading of Right Ventricular Afterload in Left Heart Disease : Relation to Right Ventricular Function, Pulsatile and Resistant Load, and Outcome

The hemodynamic definitions of pulmonary hypertension consider resistive loading (pulmonary vascular resistance [PVR]), but there are increasing evidence that pulsatile loading (pulmonary artery compliance [PAC]) has functional and prognostic importance. The aims of the present study on patients with left heart disease, were to evaluate a novel echocardiographic right ventricular (RV) afterload sc

Making sense of recent models of the "sheltering" hypothesis for recombination arrest between sex chromosomes

In their most extreme form, sex chromosomes exhibit a complete lack of genetic recombination along much of their length in the heterogametic sex. Some recent models explain the evolution of such suppressed recombination by the "sheltering"of deleterious mutations by chromosomal inversions that prevent recombination around a polymorphic locus controlling sex. This sheltering hypothesis is based on

Prediction of gene expression-based breast cancer proliferation scores from histopathology whole slide images using deep learning

Background: In breast cancer, several gene expression assays have been developed to provide a more personalised treatment. This study focuses on the prediction of two molecular proliferation signatures: an 11-gene proliferation score and the MKI67 proliferation marker gene. The aim was to assess whether these could be predicted from digital whole slide images (WSIs) using deep learning models. Met

Investigating the Influence of a Tooth Absence on Facial Bone Growth Using a Porcine Model

With the current state of knowledge regarding disorders of facial bone development, including anodontia, the development of a suitable animal model for preclinical studies is essential. The agenesis of dental buds occurs in about 25% of the human population. Prospects for treatment include the use of growth factors, stem cells, and bioengineering. This study aimed to investigate the influence of a