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Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study

Aim: To examine the hypothesis that, based on their glucose curves during a seven-point oral glucose tolerance test, people at elevated type 2 diabetes risk can be divided into subgroups with different clinical profiles at baseline and different degrees of subsequent glycaemic deterioration. Methods: We included 2126 participants at elevated type 2 diabetes risk from the Diabetes Research on Patie

Typical models of product data integration in small and medium companies

Many small companies ask themselves how and when to begin participating in the information revolution, and what changes this may bring to their business operation. Five typical models of product data integration were designed to help users to create a comprehensive view of the problems of technical information systems in companies. It was found that setting up an information system is a dynamic pr

Critique of Exaggeration : Thinking Beyond

This study examines the function of exaggeration for thinking beyond the current concepts of God and the human. An example of thinking beyond in philosophy is the exaggeration “beyond being” in Plato’s Republic. In the philosophy of religion, generally, we deal with the questions of God. The present study discerns as an instance of thinking beyond the thinking about God and the human. The study ai

Association Between Testosterone Levels and Clinical Markers of Atherosclerosis

1.1. Objectives: To investigate the association between testosterone levels and parameters obtainedfrom the clinical exercise stress test from 119 middle-aged Swedish men.1.2. Material and Methods: All subjects underwent a clinical exercise stress test and data on maximalheart rate, systolic pressure, diastolic pressure; and ST-segment levels in lead augmented vector foot(lead aVF) and lead left p

Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice

Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), such as oral xanthine oxidase inhibitors, uricosurics, and intravenous uricase agents contribute to the development of refractory gout. Renal excretion is the major route of uric acid elimination, but the intestinal tract plays an increasingly recognized role in urate homeostasis, particularly in chron

Civil beredskap i coronatider: Störst förtroende för staten och regionerna

Arbetet med civil krisberedskap är centralt för hur samhället förmår förebygga och hantera kriser av olika slag. Den civila beredskapen inkluderar grundläggande förmågor som att ge sjukvård, upprätthålla livsmedelsdistribution och se till att infrastruktur som elnät och internetkommunikation fungerar, även i en allvarlig kris eller till och med ett krig. Under coronapandemin har diskussionerna gåt

Tactical avoidance of statistics? – How students choose methods in writing theses in interdisciplinary higher education programmes

Eldh discusses the challenges in teaching quantitative methods, in this case statistics, in interdisciplinary courses with mixed methods where both qualitative and quantitative methods are taught. Despite this, most students tend to choose to use qualitative methods in their thesis research and the author researches why this is the case. Literature suggests that students often find statistics cour

Fluorine in the solar neighbourhood : Modelling the Galactic thick and thin discs

We investigate the evolution of the abundance of fluorine in the Milky Way thick and thin discs by means of detailed chemical evolution models compared with recent observational data. The chemical evolution models adopted here have already been shown to fit the observed abundance patterns of CNO and α-elements as well as the metallicity distribution functions for the Galactic thick and thin disc s

Dynamical evolution of two-planet systems and its connection with white dwarf atmospheric pollution

Asteroid material is detected in white dwarfs (WDs) as atmospheric pollution by metals, in the form of gas/dust discs, or in photometric transits. Within the current paradigm, minor bodies need to be scattered, most likely by planets, into highly eccentric orbits where the material gets disrupted by tidal forces and then accreted on to the star. This can occur through a planet-planet scattering pr

Sharing Towns : Building success with the sharing economy outside big cities

The sharing economy is sometimes described as a big city phenomenon. Among the successful examples of sharing economy, cities such as New York, Amsterdam, Seoul, Bergen, Oslo, and Gothenburg are often highlighted. But the majority of the population of Sweden and many other countries do not live in big cities, but in small towns, medium-sized cities or in a rural area. With a smaller and less dense

Chemistry, biological activities and in silico bioprospection of sterols and triterpenes from Mexican columnar Cactaceae

The Cactaceae family is an important source of triterpenes and sterols. The wide uses of those plants include food, gathering, medicinal, and live fences. Several studies have led to the isolation and characterization of many bioactive compounds. This review is focused on the chemistry and biological properties of sterols and triterpenes isolated mainly from some species with columnar and arboresc

Encounters involving planetary systems in birth environments : The significant role of binaries

Most stars form in a clustered environment. Both single and binary stars will sometimes encounter planetary systems in such crowded environments. Encounter rates for binaries may be larger than for single stars, even for binary fractions as low as 10-20 per cent. In this work, we investigate scatterings between a Sun-Jupiter pair and both binary and single stars as in young clusters.We first perfo

Economic Evaluation of Damage Accrual in an International Systemic Lupus Erythematosus Inception Cohort Using a Multistate Model Approach

Objective: There is a paucity of data regarding health care costs associated with damage accrual in systemic lupus erythematosus. The present study was undertaken to describe costs associated with damage states across the disease course using multistate modeling. Methods: Patients from 33 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) incept

Differentiation of myeloid leukemic cells in vitro demonstrated by microcalorimetry : Stimulation of leukemic and remission cells by IgG-binding Fc receptors

Interaction of immunoglobulin G (IgG)-coated latex particles with Fc receptors on myeloid leukemic blood cells and on polymorphonuclear granulocytes (PMN) from remission patients and healthy blood donors was investigated using microcalorimetry. The induced heat production by leukemic cells from 13 patients with the M2, M4 and M5 FAB groups (French-American-British classification) of acute myeloid