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Cytogenetic studies of normal kidney tissue and renal cell carcinoma

Popular Abstract in Swedish Njurcancer är ungefär den 10:e vanligaste tumörformen i Sverige och diagnosticeras nästan dubbelt så ofta hos män som hos kvinnor. Tumörerna upptäcks vanligtvis i åldern mellan 50 och 70 år och de mest förekommande symtomen är blod i urinen och flanksmärtor. Varför man får njurcancer är inte känt, men det finns ett klart samband med rökning och asbest. Njurcancer kan upIn the present thesis normal kidney tissue and renal cell carcinoma (RCC) were studied by cytogenetic and fluorescence in situ hybridization (FISH) methods to investigate chromosomal aberrations. In the first study, 4 samples of nonneoplastic kidney tissue were cultured for cytogenetic analysis and trisomy 7 was found in all cases in 3-15% of the cells. In the second study, cytogenetic analysis o

Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intr

Flexible Synthesis of Rigid Cyclophanes - Synthesis and derivatisation of 2,7-diaza-1,2,3,6,7,8-hexahydropyrene into chiral macrocycles

Rigid, chiral and amphiphilic cyclophanes of potential use as biomimetic host molecules were prepared by cyclic dimerisation of chiral diamino building blocks with amino-reactive cross-linking reagents. A reliable synthesis of the scaffold 2,7-diaza-1,2,3,6,7,8-hexahydropyrene was developed. Chiral bidentate building blocks were formed by acylation of the aromatic diamine 2,7-diaza-1,2,3,6,7,8-hex

Efficient Iterated Filtering

Parameter estimation in general state space models is not trivial as the likelihood is unknown. We propose a recursive estimator for general state space models, and show that the estimates converge to the true parameters with probability one. The estimates are also asymptotically Cramer-Rao efficient. The proposed estimator is easy to implement as it only relies on non-linear filtering. This makes

Rapport om SI-verksamheten vid gymnasiet 2010/11

LTH:s SI-verksamhet på gymnasiet är ett samarbete mellan LTH och elva gymnasieskolor i närregionen som startade under hösten 2007 och går ut på att använda den s.k. SI-metodiken som komplement till den ordinarie undervisningen i naturvetenskapliga ämnen. SI-mötena leds av teknologer från LTH. Syftet med samarbetet är flera: att förbättra samverkan mellan LTH och gymnasieskolor i närregionen; öka i

Inhibiting and driving forces for the digitalization of security systems: security officers’ view on the issue

This memo reports on factors that drive and inhibit the digitalization of security systems. The reported factors are as follows: Technology-push factors • Need to lower costs on the end-user side, i.e. replacing labour with technology • Perceived convenience and ease-of-use of digital systems • Digital products can be connected to the current enterprise network; enabling an expanding set of secur