Search results

Filter

Filetype

Your search for "*" yielded 528841 hits

Comparative cytogenetic and DNA flow cytometric analysis of 150 bone and soft-tissue tumors

Samples from 48 benign and 102 malignant bone and soft-tissue tumors were analyzed cytogenetically and by DNA flow cytometry. Clonal chromosome abnormalities were found in 82 tumors and normal karyotypes in 68; 61 tumors were DNA-non-diploid and 89 were diploid. The cytogenetically abnormal tumors were used for comparison between the 2 types of investigation; 45 of these tumors were DNA-diploid an

Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children

Extracorporeal photochemotherapy (ECP) has demonstrated immunological effects. The proposed cytotoxic lymphocyte antigen 4 (CTLA-4) involvement, together with forkhead box P3 (FoxP3) and transforming growth factor (TGF)-beta are associated with regulatory T cell activity. The aim of the study was to evaluate the regulatory T cell-associated effect of ECP in recent onset type 1 diabetic (T1D) child

Structural Changes in the Transition State of Protein Folding: Alternative Interpretations of Curved Chevron Plots

The interpretation of folding rates is often rationalized within the context of transition state theory. This means that the reaction rate is linked to an activation barrier, the height of which is determined by the free energy difference between a ground state (the starting point) and an apparent transition state. Changes in the folding kinetics are thus caused by effects on either the ground sta

Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.

Oxi4503, which is the diphosphate prodrug of combretastatin A1, is a novel vascular targeting agent from the combretastatin family. Another member of this family, Combretastatin A-4 phosphate (CA4P), is a well-characterized vascular targeting agent already being evaluated in clinical trials. The potential for tumor vascular targeting by Oxi4503 was assessed in a mouse system. This approach aims to

Organizational Effectiveness of Ugandan Building Firms as Viewed by Craftsmen

Construction industries, especially those in developing countries, face the problems of low productivity. It comes about partly due to organizational ineffectiveness. The major attributes of organizational effectiveness are identified from literature. Means to achieving greater organization effectiveness and higher productivity are identified under the major headings of cohesion and morale of work

Hypertension mechanisms causing stroke

1. Although it is well established that hypertension is the main risk factor for stroke, the complexity of cerebrovascular problems related to hypertension is not generally appreciated. 2. Hypertension can cause stroke through many mechanisms. A high intraluminal pressure will lead to extensive alteration in endothelium and smooth muscle function in intracerebral arteries. The increased stress on

Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose

OBJECTIVES: This study assessed the health effects of occupational acrylamide exposure using hemoglobin (Hb) adducts as biomarkers of internal dose. METHODS: Two hundred and ten tunnel workers exposed for about 2 months to a chemical-grouting agent containing acrylamide and N-methylolacrylamide underwent a health examination. Blood samples were drawn for the analysis of Hb adducts of acrylamide. F

Atomic Cholesky decompositions: A route to unbiased auxiliary basis sets for density fitting approximation with tunable accuracy and efficiency

Cholesky decomposition of the atomic two-electron integral matrix has recently been proposed as a procedure for automated generation of auxiliary basis sets for the density fitting approximation [F. Aquilante , J. Chem. Phys. 127, 114107 (2007)]. In order to increase computational performance while maintaining accuracy, we propose here to reduce the number of primitive Gaussian functions of the co

A distributed scheme for optimization of interdomain routing between collaborating domains

As today’s market forces the implementation of quality-of-service-enabled services spanned over multiple administrative domains, isolated and locally optimized interdomain routing decisions become increasingly inadequate. Instead, coordinated routing models are required together with joint optimization goals. Available papers and standardization documents focus on the description of technical mean

An empirical parameterization of heterogeneous ice nucleation for multiple chemical species of aerosol

A novel, flexible framework is proposed for parameterizing the heterogeneous nucleation of ice within clouds. It has empirically derived dependencies on the chemistry and surface area of multiple species of ice nucleus (IN) aerosols. Effects from variability in mean size, spectral width, and mass loading of aerosols are represented via their influences on surface area. The parameterization is inte

Interaction between poly(ethylene glycol) and C12E8 investigated by dynamic light scattering, time-resolved fluorescence quenching, and calorimetry

Dynamic light scattering (DLS), time-resolved fluorescence quenching (TRFQ), and isothermal titration microcalorimetry have been used to show that, in dilute solution, low molecular weight poly(ethylene glycol) (PEG, M-w = 12 kDa) interacts with the nonionic surfactant octaethylene glycol n-dodecyl monoether, C12E8, to form a complex. Whereas the relaxation time distributions for the binary C12E8/

Dose resolution in radiotherapy polymer gel dosimetry: effect of echo spacing in MRI pulse sequence

In polymer gel dosimetry using magnetic resonance imaging, the uncertainty in absorbed dose is dependent on the experimental determination of T2. The concept of dose resolution (Dpdelta) of polymer gel dosimeters is developed and applied to the uncertainty in dose related to the uncertainty in T2 from a range of T4 encountered in polymer gel dosimetry. Dpdelta is defined as the minimal separation

Mental representations of important real-life decisions

Two studies investigated how decision makers characterize alternatives in important real-life decisions, which they themselves had made (to leave a partner, to choose an education and to choose a home). First, the participants indicated a very high degree of involvement in the decisions studied and about half of the participants gave maximum involvement ratings for the partner decision. Second, th

Altered expression of the retinoblastoma tumor-suppressor gene in leukemic cell lines inhibits induction of differentiation but not G1-accumulation

The retinoblastoma tumor-suppressor gene, RB, has been implicated in tumor suppression, in regulation of the cell cycle, and in mediating cell differentiation. RB is necessary for hematopoiesis in mice, and aberrant RB-expression is associated with the progress and prognosis of leukemia. We have used antisense oligonucleotides, established clones stably expressing an antisense RB construct, and al

Whose Quality of Life? Ethical Implications in Patient-Reported Health Outcome Measurement

Patient-reported health status questionnaires intend to assess illness and therapy from the patients' perspective. To provide fair and valid assessments, they should be equally relevant to major subsets of respondents. Furthermore, disease-specific measures are assumed to be perceived as more relevant than generic ones. This study assessed these assumptions among people with Parkinson's disease. C

Endometrial thickness and Doppler velocimetry of the uterine arteries as discriminators of endometrial status in women with postmenopausal bleeding: a comparative study

OBJECTIVE: Our purpose was to compare the ability of transvaginal Doppler ultrasonographic examination with that of gray-scale ultrasonographic examination to discriminate between benign and malignant and between normal and pathologic endometrium in women with postmenopausal bleeding. STUDY DESIGN: One hundred thirty-eight consecutive women scheduled for curettage because of postmenopausal bleedin

A new approach to study dispersal: immigration of novel alleles reveals female-biased dispersal in great reed warblers

We use the assignment technique and a new approach, the 'novel allele technique', to detect sex-biased dispersal in great reed warblers Acrocephalus arundinaceus . The data set consisted of immigrants and philopatric birds in a semi-isolated population in Sweden scored at 21 microsatellite loci. Fourteen cohorts were represented of which the four earliest were used to define a reference population

Urinary excretion of a glucose-containing tetrasaccharide. A parameter for increased degradation of glycogen

The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excret