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Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions.

Solid tumors exhibit chromosomal rearrangements resulting in gain or loss of multiple chromosomal loci (copy number variation, or CNV), and translocations that occasionally result in the creation of novel chimeric genes. In the case of breast cancer, although most individual tumors each have unique CNV landscape, the breakpoints, as measured over large datasets, appear to be non-randomly distribut

Hydrogen Peroxide Vapor Decontamination in a Patient Room Using Feline Calicivirus and Murine Norovirus as Surrogate Markers for Human Norovirus.

OBJECTIVE To determine whether hydrogen peroxide vapor (HPV) could be used to decontaminate caliciviruses from surfaces in a patient room. DESIGN Feline calicivirus (FCV) and murine norovirus (MNV) were used as surrogate viability markers to mimic the noncultivable human norovirus. Cell culture supernatants of FCV and MNV were dried in triplicate 35-mm wells of 6-well plastic plates. These plates

Kvalitetsregistrering ett stöd för bättre specialiserad palliativ vård. : Nio av tolv indikatorer förbättrades signifikant under ett år.

Systematic improvement of quality of care at the end of life is still scarce. The regional palliative care service in Skåne, which has eight units covering a population of almost 1.3 million inhabitants, has systematically used the Swedish Register of Palliative Care (SRPC, http://www.palliativ.se/ ) for care development. 9 out of 12 of the indicators improved significantly in 2014 compared to 201

On the dispersion equation for a homogeneous, bi-isotropic waveguide of arbitrary cross-section

In this article, we consider the propagation problem inside a waveguide filled with a homogeneous bi-isotropic material. The cross section of the waveguide is assumed arbitrary. By using the classical theory for the 2D Helmholtz equation in the cross section and the null-field approach, we obtain the dispersion equation in an implicit form. The final equation is a potential candidate for the solut

Natural Vision for Artificial Systems, Active Vision and Thought

The visual system in animals and humans consists of a number of information processing units that are here called visual routines. These routines are specialized in handling different cognitive tasks, for example, object recognition, motion, stereo, color, texture, and optic flow. together, these routines contribute to the internal representation of the visual world. On the top of this network of

Is chronic diabetic foot ulcer an indicator of cardiac disease?

OBJECTIVE: To evaluate presence and severity of cardiac disease in individuals with chronic diabetic foot ulcers using echocardiography. METHOD: Eighty consecutive patients with chronic foot ulcers attending the multidisciplinary diabetes foot clinic at Helsingborg Hospital underwent clinical examination, toe blood pressure measurement and a standard echocardiographic examination. RESULTS: Sixty-n

Oestrogen receptors alpha and beta show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer.

AIMS: The majority of all breast cancers are hormone responsive, traditionally defined by the expression of oestrogen receptor (ER) alpha and/or progesterone receptors. In contrast to ERalpha, the clinical significance of the relatively recently identified ERbeta is still unclear. This study aimed to define the relationship between ERbeta and clinicopathological parameters in a mixed cohort of bre

Tryptophan end-tagging of antimicrobial peptides for increased potency against Pseudomonas aeruginosa.

BACKGROUND: Due to increasing antibiotics resistance, antimicrobial peptides (AMPs) are receiving increased attention. Pseudomonas aeruginosa is a major pathogen in this context, involved, e.g., in keratitis and wound infections. Novel bactericidal agents against this pathogen are therefore needed. METHODS: Bactericidal potency was monitored by radial diffusion, viable count, and minimal inhibitor