Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD sy

Dense urban morphologies further amplify extreme climate events due to the urban heat island phenomenon, rendering cities more vulnerable to extreme climate events. Here we develop a modelling framework using multi-scale climate and energy system models to assess the compound impact of future climate variations and urban densification on renewable energy integration for 18 European cities. We obse

Climate change and urbanisation are among the most pervasive and rapidly growing threats to biodiversity worldwide. However, their impacts are usually considered in isolation, and interactions are rarely examined. Predicting species' responses to the combined effects of climate change and urbanisation, therefore, represents a pressing challenge in global change biology. Birds are important model t

Understanding the effects of tree species and their mycorrhizal association on soil processes is critical for predicting the ecosystem consequences of species shifts owing to global change and forest management decisions. While it is well established that forests dominated by different mycorrhizal types can vary in how they cycle carbon (C), nitrogen (N) and phosphorus (P), the degree to whi

Several promising plasma biomarkers for Alzheimer's disease have been recently developed, but their neuropathological correlates have not yet been fully determined. To investigate and compare independent associations between multiple plasma biomarkers (p-tau181, p-tau217, p-tau231, Aβ42/40, GFAP, and NfL) and neuropathologic measures of amyloid and tau, we included 105 participants from the Arizon

Aim: After low anterior resection, the bowel can be anastomosed in different ways. It is not clear which configuration is optimal from a functional and complication point of view. The primary aim was to investigate the impact of the anastomotic configuration on bowel function evaluated by the low anterior resection syndrome (LARS) score. Secondarily, the impact on postoperative complications was e

Aim: The increasing spread of vector-borne diseases has resulted in severe health concerns for humans, domestic animals and wildlife, with changes in land use and the introduction of invasive species being among the main possible causes for this increase. We explored several ecological drivers potentially affecting the local prevalence and richness of avian malaria parasite lineages in native and

Background: Per- and polyfluoroalkyl substances (PFAS) have been suggested to contribute to the development of metabolic diseases such as obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). However, evidence from epidemiological studies remain divergent. The aim of the present study was to evaluate associations between PFAS exposure and prevalent diabetes in a cross-sectional analysis

We consider Waveform Relaxation (WR) methods for parallel and partitioned time-integration of surface-coupled multiphysics problems. WR allows independent time-discretizations on independent and adaptive time-grids, while maintaining high time-integration orders. Classical WR methods such as Jacobi or Gauss-Seidel WR are typically either parallel or converge quickly.We present a novel parallel WR

Learning by teaching someone else has proven to be beneficial in both human-human and human-agent interaction. Instructing someone else, that is, taking the role as a tutor, has a series of positive effects on students' learning and performance. For example, the fact that someone else is in need of help seems to affect students to put more effort into the task at hand, trying harder, being more th

In this paper, we argue for the importance of conducting replication studies over various schools and countries when addressing topics about learning and instruction and propose educational technology to be a tool for this endeavor. We present an example of a cross-cultural replication study that makes use of educational technology in the form of a digital game-based automated feedback system. The

Do virtual representations, intended for teaching and learning, afford different constraints and affordances compared to their physical twins, and may this lead to different ways of interaction and understanding? In this line of inquiry, and with the perspective on learning as an extended activity, where learning can be mediated through the interaction with artefacts, the present study has transla

Sarah Anne Rennick is Deputy Director at the Arab Reform Initiative. In this episode, she discusses how youth navigates conflict, and how it affects their whole lives. She uses on-ground surveys from the Middle East region. More information about the issue can be found in her paper here: https://www.tandfonline.com/doi/full/10.1080/14678802.2023.2188569#.ZBlhJTKb-v0.twitter.

This article focuses on the importance that municipal schools have, and potentially can have, in counteracting radicalisation in relation to Salafist-Jihadist extremism in Sweden. The purpose of the study is to provide a review of previous research into radicalisation, with a specific focus on the role of schools. In addition to the review, there is a minor qualitative interview study with teacher

The recent rise in atmospheric methane (CH4) concentrations accelerates climate change and offsets mitigation efforts. Although wetlands are the largest natural CH4 source, estimates of global wetland CH4 emissions vary widely among approaches taken by bottom-up (BU) process-based biogeochemical models and top-down (TD) atmospheric inversion methods. Here, we integrate in situ measurements, multi-

Aeolian sand significantly affects permafrost degradation, but the effect of the aeolian sand on the permafrost on the Qinghai-Tibet Plateau remains unknown. The sand layer thickness is critical to its role. However, little quantitative research has been conducted on the effect of the sand layer thickness on its role. In this study, using CoupModel, we investigated the differences in the impact of

The aim of this paper is to find appropriate approximate expressions of the coherent electromagnetic field scattered by a particulate slab.The exact solution of the coherent electric field to the multiple scattering problem in the slab is determined by the solution of a set of integral equations. By iterating the integral equations, an approximate solution is obtained, which approximates the solutThe aim of this paper is to find appropriate approximate expressions of thecoherent electromagnetic field scattered by a particulate slab. The exact solution of the coherent electric field to the multiple scattering problem in the slabis determined by the solution of a set of integral equations. By iterating theintegral equations, an approximate solution is obtained, which approximatesthe solution