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Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Parental age is increasing rapidly in many countries. Analysis of this potentially important influence on offspring well-being is hampered by strong secular trends and socioeconomic patterning and by a shortage of follow-up data for adult offspring. We used Swedish national data on up to 3,653,938 offspring to consider the associations of parental age with a suite of outcomes in adult offspring, c

Third cumulant for multivariate aggregate claim models

The third cumulant for the aggregated multivariate claims is considered. A formula is presented for the general case when the aggregating variable is independent of the multivariate claims. Two important special cases are considered. In the first one, multivariate skewed normal claims are considered and aggregated by a Poisson variable. The second case is dealing with multivariate asymmetric gener

Hyperparameter-free sparse regression of grouped variables

In this paper, we introduce a novel framework for semi-parametric estimation of an unknown number of signals, each parametrized by a group of components. Via a reformulation of the covariance fitting criteria, we formulate a convex optimization problem over a grid of candidate representations, promoting solutions with only a few active groups. Utilizing the covariance fitting allows for a hyperpar

Trace-based manycore partitioning of stream-processing applications

Application performance on these processor array platforms is highly sensitive to how functionality is physically placed on the device, as this choice crucially determines communication latencies and congestion patterns of the on-chip inter-core communication. The problem of identifying the best, or just a good enough, partitioning and placement does not, in general, admit to an analytic solution,

A targeted approach to maintenance of tumour response. Clinical and translational studies in metastatic colorectal cancer.

In metastatic colorectal cancer (mCRC) chemotherapy +/- targeted therapy with palliative intent aims at prolonging survival with sustained quality of life. Maintenance of tumour response by a period of less intense treatment maydelay progression and accumulation of unacceptable toxicity. We studied the combination of targeted treatment with the angiogenesis inhibiting antibody bevacizumab (bev) an

Det tidiga klosterväsendet och den antika bildningen. : Slutrapport från ett forskningsprogram

Denna rapport sammanfattar resultaten av forskningsprogrammet ”Det tidiga klosterväsendet och den antika bildningen”, som pågick åren 2009-2015. Rapporten är författad av programmets forskningsledare Samuel Rubenson, men bygger på det omfattande arbete som gjorts av programmets olika forskare: Elin Andersson, Anahit Avagyan, Jesper Blid Kullberg, Karin Kulneff-Eriksson, Britt Dahlman, Bo Holmberg,