Multiple genetic hits are detected in patients with acute myeloid leukemia (AML). To investigate this further, we developed a tetracycline-inducible mouse model of AML, in which the initial transforming event, overexpression of HOXA10, can be eliminated. Continuous overexpression of HOXA10 is required to generate AML in primary recipient mice, but is not essential for maintenance of the leukemia.

Abstract in Uncoded languages A kooperatív játékelmélet egyik legjelentősebb eredménye, hogy számos konfliktushelyzetben stabil megoldást nyújt. Ez azonban csak statikus és determinisztikus környezetben alkalmazható jól. Most megmutatjuk a mag egy olyan kiterjesztését, a gyenge szekvenciális magot, mely képes valós, dinamikus, bizonytalan környezetben is eligazítást nyújtani. A megoldást a csődját

Previously, a positive effect of exercise on cartilage structure was indicated with delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). However, in that study only one full-thickness region of interest (ROI) in the medial femoral condyle was analyzed.

Objectives: The aim of this study was to explore nurses' experience of strain in dementia care. Method: Focus groups were held with 35 nurses in Sweden, Australia and UK, who care for people with dementia. The discussions were tape-recorded and analysed using qualitative content analysis. Results: The nurses described the complexity of their situation and referred to environmental factors such as

This paper is about automatic classification of dialect and accent type in Swedish. We used disyllabic words from the speech material of the Swedia 2000 dialect project in order to build a statistical prediction model. The model uses different parameters extracted from F0 contours of the words. Classification of dialect is performed for the features 'province' and 'village', whereas classification

BACKGROUND: A flow cytometric method for detection of low levels of A/B antigen had been developed previously in our laboratory. The aim of this study was to investigate if this approach could be utilized to characterize different ABO subgroups and constitute a useful tool in a reference laboratory. STUDY DESIGN AND METHODS: Blood samples causing ABO discrepancies (n = 94) by routine serology were

Controlled resistive loads can contribute to damping of electro-mechanical oscillations. This paper presents an on-off damping controller for a single machine system. It was used at a field test in Southern Sweden to damp oscillations of a 0.9 MW hydro power generator. The controller used estimated machine frequency as input and controlled a 20 kW resistive load via thyristor switches. The field m

Abstract Objective: To evaluate long-run cost-effectiveness in a Swedish setting for liraglutide compared with sulphonylureas (glimepiride) or sitagliptin, all as add-on to metformin for patients with type 2 diabetes insufficiently controlled with metformin in monotherapy. Methods: The IHE Cohort Model of Type 2 Diabetes was used to evaluate clinical and economic outcomes from a societal perspecti

On the macro level, bankruptcies are an intrinsic part of market economies and result in restructurings of companies and markets. On the micro level, bankrupt entrepreneurs are temporarily excluded from the market and forced to reorganize their understanding of the market. While some seek their way back to entrepreneurship, others decide to find other means of living which may result in drainage o

Spinal deformities affect young individuals predominantly girls who are usually subjected to regular and intensive radiological investigation especially before and after corrective surgery. Optimisation of spine computed tomography (CT) and the implementation of the low-dose CT in the work-up of spinal deformities were presented. The presented low-dose CT here means providing the operating surgeon

The menisci play a critical protective role for the knee joint through shock absorption and load distribution. Asymptomatic meniscal tears are common and are frequent incidental findings on knee MR imaging of the middle-aged or older patient. A meniscal tear can lead to knee osteoarthritis (OA), but knee OA can also lead to a spontaneous meniscal tear through breakdown and weakening of meniscal st

BACKGROUND: Information on autonomic neurapraxia in female urogenital surgery is scarce, and a model to study it is not available. OBJECTIVE: To develop a model to study the impact of autonomic neurapraxia on bladder function in female rats, as well as to assess the effects of corticosteroid therapy on the recovery of bladder function in this model. DESIGN, SETTING, AND PARTICIPANTS: Female Spra

A technique for implementing Ada with reasonable effort on a piece of non-standard hardware is described. The target machine is a single processing element in an experimental multiprocessor based on NS32000. A portable Ada front-end compiler was used for retargeting, and the process of acquiring and evaluating the front end is described. Based on this experience, comments on the validation, qualit

Abstract not available

During the 1990s, Latin America went through important structural transformations. The continent experienced a profound alteration in the relations between the state, society, market and natural environment. Societies have been trying to accommodate, contest and resist this restructuring, particularly once it became evident its negative effects on poverty reduction and the increasingly social and

System Dynamics (SD) is a method that allows for integrated modelling of technical as well as managerial aspects responsible for the dynamic complexity of systems. Therefore, simulation of SD models can also be a tool for problem analysis within software organisations. In this paper, experience with SD modelling of software processes and projects within Siemens is reported. Special focus is put on