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Aging Hematopoiesis: Functional Insights and Prospects for Rejuvenation

Aging exerts profound effects on the hematopoietic system, leading to a loss of homeostatic control and reduced regenerative capacity. Clinical consequences of these changes include anemia, compromised immune function and an increased prevalence of myeloid disorders among the elderlies. A growing body of evidence suggests that defects at the stem and progenitor cell levels contribute to many of th

A revised checklist and time window based province catalogue of the long-legged flies (Diptera: Dolichopodidae) of Sweden, with six new synonymies in Dolichopus Latreille, 1796

Familjen styltflugor (Dolichopodidae) är en flugfamilj som i Sverige rönt ganska stor uppmärksamhet under de senaste tvåhundra åren. Ett flertal checklistor har publicerats, den senaste 2004. Trots detta har ingen regelrätt landskapskatalog upprättats. En landskapskatalog visar inte bara vilka arter som finns i landet utan också i vilken del av landet de olika arterna förekommer. En tidsfönsterbas

A strong Borel–Cantelli lemma for recurrence

Consider a dynamical systems ([0, 1], T, µ) which is exponentially mixing for L1 against bounded variation. Given a non-summable sequence (mk) of non-negative numbers, one may define rk(x) such that µ(B(x, rk(x)) = mk. It is proved that for almost all x, the number of k ≤ n such that Tk(x) ∊ Bk(x) is approximately equal to m1+· · ·+mn. This is a sort of strong Borel–Cantelli lemma for recurrence.

Kommersiellt delägande av bostadsrätter och ägarlägenheter – behövs lagstiftning?

Delägande av bostadsrätter mellan en boendedelägare och en kommersiell delägare är en ny företeelse i Sverige. OBOS införde deleie-modellen efter att ha utvecklat den i Norge. Där har systemet fungerat väl under lång tid. Norska kommersiella aktörer är starkt begränsade av viktiga rättsregler och de rättsliga oklarheter som där finns håller på att klarläggas. Sverige är på många sätt annorlunda. O

Time-Adaptive Determination of Drug Efficacy in Mathematical Model of HIV Infection

The paper considers a time-adaptive finite element method for determination of drug efficacy in a parameter identification problem (PIP) for a system of ordinary differential equations (ODE) that describes dynamics of the primary human immunodeficiency virus (HIV) infection with drug therapy. Tikhonov’s regularization method, optimization approach and finite element method to solve this problem ar

Predictors of diagnostic conversion from major depression to bipolar disorder : A Swedish national longitudinal study

Background It is clinically important to predict the conversion of major depression (MD) to bipolar disorder (BD). Therefore, we sought to identify related conversion rates and risk factors. Methods This cohort study included the Swedish population born from 1941 onward. Data were collected from Swedish population-based registers. Potential risk factors, including family genetic risk scores (FGRS)

The breakup of the L-chondrite parent body 466 Ma and its terrestrial effects-a search for a mid-Ordovician biodiversity event

About a third of all meteorites that fall on Earth today, the stony L-chondrites, originate from a major breakup event in the asteroid belt 466 Ma, in the early Darriwilian. This is the largest asteroid breakup in the past three billion years documented by K-Ar gas-retention ages of recently fallen meteorites. There has been a debate whether the breakup had any effects on Earth’s biota. Based main

CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic β-cells

Background and Purpose: High levels of Ca2+ in the endoplasmic reticulum (ER), established by the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), are required for protein folding and cell signalling. Excessive ER Ca2+ release or decreased SERCA activity induces unfolded protein accumulation and ER stress in pancreatic β-cells, leading to defective insulin secretion and diabetes. Here we have inve

Sounding Pico

Sounding Pico is an art project focussing on the Pico-neighbourhood in Santa Monica, CA in the USA –developed in collaboration between artist Maj Hasager and composer Ask Kæreby during winter 2018-19. In response to the often-mediated image of a troubled area with opportunities lost, rather than gained, countermeasures have been taken – perhaps most notably by the cultural asset database Culture M

Statistical properties of aftershock rate decay : Implications for the assessment of continuing activity

Aftershock rates seem to follow a power law decay, but the assessment of the aftershock frequency immediately after an earthquake, as well as during the evolution of a seismic excitation remains a demand for the imminent seismic hazard. The purpose of this work is to study the temporal distribution of triggered earthquakes in short time scales following a strong event, and thus a multiple seismic

A homogeneous earthquake catalog for western Turkey and magnitude of completeness determination

A catalog for earthquakes that occurred in western Turkey during the period 1964-2010 is compiled for achieving homogeneity for magnitudes. Data are obtained from the International Seismological Center (ISC), where earthquake magnitudes are reported in different scales and come from a variety of sources. For establishing a common magnitude expression, namely an equivalent moment magnitude Mw*, new