A translocation between chromosomes 9 and 22 produces the fusion gene BCR-ABL that leads to the constitutive activity of a tyrosine kinase. This initiates the uncontrolled proliferation of myeloid cells causing Chronic Myeloid Leukaemia (CML). The disorder is treated by tyrosine kinase inhibitors (TKIs) that prevent the progression of CML into more advanced phases. The treatment must be sustained

Gotland Regiment P 18 was disbanded in 2004. Gotland had been a historically important strategic island for over 200 years and the Regiment was one of many that where to be disbanded due to economic restraints and a new Swedish security policy. The aim of this thesis is to examine why the decision was made due to the fact that the Regiment was re-established in 2018. Was it a rational decision or

Detta examensarbete är ett samarbete mellan Institutionen för Industriell Produktion på Lunds Tekniska Högskola och Trelleborg AB. Målet med arbetet är att analysera polymerhanteringen i Trelleborgs mixing-avdelning utifrån ett lean perspektiv, samt att komma fram till ett nytt förbättrat produktionsflöde. Det nya flödet ska vara effektivare när det kommer till kapacitet, operatörstid, trucktranspThis thesis is a collaborative project between the division of Production and Materials Engineering and Trelleborg AB. The aim of the thesis is to analyse the current pre-batch polymer handling process, assess the current process from a Lean perspective, and provide a new handling process which is more effective in terms of capacity, operator time, forklift transportation and traceability. The cur

Now more than ever, climate change poses one of the greatest threats to our existence. Regardless of religion, economical wealth, culture or politics, no-one can escape the imminent consequences of climate change. There have been numerous efforts made by political leaders world-wide to prevent climate change and develop sustainable solutions. However, due to conflicting political wills and the com

Den särskilda utskrivningsprövningen inom den rättspsykiatriska vården har varit omdiskuterad under en längre tid. Flera statliga utredningar har gjorts och en del uppmärksammade fall med lagöverträdare som suttit inom vården uppemot 20 år har skapat en het debatt. Denna uppsats ger en närmare inblick i systemet kring särskild utskrivningsprövning och vilka intressen som är centrala när bedömningaThe special discharge review within forensic pshyciatry has been a controversial subject during a longer period of time. A couple of state investigations have been made and several high-profile cases with offenders who have been within the psyciatric care upwards 20 years have created a great debate. This essay will give a closer look into the system around special discharge review and the central

Undersökning av cellens mekaniska reaktionsväg Cancer är ett existentiellt problem världen runt. Den kan uppstå i nästan vilken vävnad som helst och innebär att vissa celler börjar dela sig obehindrat. Dessutom kan tumörceller sprida sig till andra delar av kroppen och bilda så kallade metastaser. Ibland räcker det att lokalt ökad styvhet bidrar till cancercellernas metastasering och på det sätteCells can sense and respond to mechanical forces through a process called mechanotransduction. It is controlled by the mechanical cues, originated from the cell's microenvironment, and occurs via a complex, step-wise process. In this process, a cascade of events occurs, where the forces are essentially sensed by integrins and transmitted through filamentous actin (F-actin). The downstream even

In the 2017 paper by Arévalo and Söderlind, a framework was established for creating linear multistep methods of various classes based on a polynomial formulation which includes variable step size adaptivity. These classes are: k step explicit and implicit methods of order k and k+1 respectively for nonstiff problems (such as Adams methods), and k step implicit methods of order k for stiff problem

Object and surface reconstruction in 3D is commonly used in production tolerance validation. Depending on the required level of accuracy, a multitude of different methods are available, each with their own advantages and disadvantages. This thesis aims to investigate alternative surface reconstruction methods which utilise that all possible light paths are known along a given one-dimensional cur

The Anthropocene is facing complex issues that require paradigmatic shifts in thought and action. In this context, systemic change and cross-sectoral partnerships have gained an exceptional wave of support through agreements such as Agenda 2030, shaping the landscape of international development cooperation sector. However, conceptual limitations and methodological gaps pose challenges to understa

Both development practice and research have paid attention to the issue of sexual and gender-based violence in armed conflict in recent years. However, feminist scholars criticise policies on the issue for reproducing the gendered power relations which are at the root of violence. Research focuses on the policies of a few prominent donors, while policies of lesser-known actors have hardly been exa

There is a need for more efficient measures to ensure responsible migration in host countries. Sports are recognised as a key measure to promote integration. This thesis’s purpose is to increase the understanding of the impacts football clubs have on integration for youth girls with foreign backgrounds in Stockholm, Sweden. This is done by exploring social relations’ role in integration and examin

The under-representation of women in public decision-making in Peru has reaffirmed the need for further studying the reasons for low representation. This study focuses on the case at the lowest level of the Peruvian Judiciary: the Justices of the Peace (JoP) who judge cases in their community based on the knowledge of the specific sets of values in the community. The study shines light on the (und

Covid-19 has served as a magnifying lens to the globally prevailing issue of domestic violence against women. This qualitative case study examines why domestic violence against women prevails in Pakistan, what factors have led to its increase during Covid-19, and how have civil society organizations responded to this issue. Primary data was collected through online interviews with 11 civil society

Climate migration is an emerging topic of research and policymaking in the region of Asia and the Pacific. Migration in the context of climate change is mediated by social, political, and historical factors not solely dependent on the impacts of climate change. Also, migration, including climate migration, is a socially unequal process and has differential impacts on people based on their identity

Efforts to empower Albanian women and strengthen their participation in decision-making in local Forest and Pasture Users’ Associations (FPUAs) have been undertaken by the Environmental Services Project, including implementing the Gender Action Plan. The phenomenon of women’s agency and participation in decision-making in this local setting is examined in this study by answering the following: (I)

Social inequalities predominantly shape the population's health outcomes. Especially, basic social structures are the fundamental causes of determinants of health. Meanwhile, there are active intermediary factors of the social determinants of health introduced by the Commission on Social Determinants of Health. This study aims to examine those factors, alongside a fundamental cause perspective

The study examines pleasure-inclusive CSE within the case of RFSU and their partner organizations and their experiences of challenges and possibilities with CSE implementation and its cultural sensitivity. Experiences in both formal national CSE curricula such as in school- settings, and non-formal settings which reach out-of-school youth, such as in community centres or faith-based organizations,

Objectives. Armenia demonstrates disastrous environmental and human health outcomes in mining-reliant regions with high indicators of environmental pollution, loss if biodiversity, and degraded human health caused by mining and processing activities. The study investigates the negative environmental and health impacts of such activities in Lori, Armenia to understand the neglected aspects, whic

The Logical Framework Approach (LFA) has been a prevailing project management tool in the international development sector for decades, largely driven by donors. However, few studies have analysed its use from the practitioner perspective. The few studies done on the topic flag several issues with LFA, and some also suggest alternatives. Sweden is a leading actor in the development aid sector, and

The purpose of the thesis is to examine the gender perception of a project designer, project implementers, and beneficiaries in disaster risk reduction (DRR) projects in Cambodia. This thesis studies a specific DRR project called the Adaptive and Resilient Communities (ARCII) project of a Swedish non-government organization (NGO), and the local partner in Cambodia. The research questions are as fo