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Immune thrombocytopenia (ITP) is characterized by a dysregulated immune response against platelets, affecting both their destruction and production. A role for an abnormal T-cell compartment has been established in ITP pathogenesis and treatments that increase platelet counts in patients with ITP have shown improvements in T-cell profiles. On the other hand, patients who were refractory to treatme
Rationale & Objective: Use of cystatin C in addition to creatinine to estimate glomerular filtration rate (estimated glomerular filtration rate based on cystatin C [eGFRcys] and estimated glomerular filtration rate based on creatinine [eGFRcr], respectively) is increasing. When eGFRcr and eGFRcys are discordant, it is not known which is more accurate, leading to uncertainty in clinical decisio
This article is a reaction to previous appeals to widen the conceptual remit of Critical Discourse Studies (CDS). It proposes research bricolage as means for critical engagement with conceptual constructs originating from adjacent social science disciplines. Borrowing such concepts as far-right metapolitics from political science, superordinate intersectionality from gender studies, and Web 2.0 so
Severe Plasmodium falciparum malaria infections are caused by microvascular sequestration of parasites binding to the human endothelial protein C receptor (EPCR) via the multi-domain P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion ligands. Using cryogenic electron microscopy (Cryo-EM) and PfEMP1 sequence diversity analysis, we found that group A PfEMP1 CIDRα1 domains interact with t
Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non–muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatmen
Urbanisation is one of the biggest environmental challenges of our time, yet we still lack an integrative understanding of how cities affect behaviour, physiology and parasite susceptibility of free-living organisms. In this study, we focus on carotenoids, strictly dietary micronutrients that can either be used as yellow-red pigments, for integument colouration (signalling function), or as antioxi
Background: The diagnostic accuracy of digital breast tomosynthesis (DBT) and digital mammography (DM) in breast cancer screening may vary per breast density subgroup. The purpose of this study was to evaluate which women, based on automatically assessed breast density subgroups, have the greatest benefit of DBT compared with DM in the prospective Malmö Breast Tomosynthesis Screening Trial. Materi
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory joint disease that affects all aspects of life. Rheumatology care strives to achieve optimal health based on person-centred care (PCC). Effective treatment is available, but patients still experience unmet needs.Aims: The overall aim of this thesis was to explore patients' perspectives of PCC and preferred outcomes in early RA. Specifi
Background: Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods: These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl
Background: Free oxygen radicals have been implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants. Superoxide dismutase (SOD) is a naturally occurring enzyme which provides a defense against such oxidant injury. Providing supplementary SOD has been tested in clinical trials to prevent BPD in preterm infants. Objectives: To determine the efficacy and safety of SOD in
Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolvability is subject to natural selection and thus plays a critical role in eco-evolutionary dynamics. Understanding this role provides insight into how species
This book presents the findings of an in-depth qualitative longitudinal investigation into the willingness to communicate (WTC) of individuals who, through varying migration channels, left one cultural/linguistic context to make a new life in another. It examines communication behaviours and language choice in multilingual community contexts and emphasises how even the most trivial of communicatio
The detailed study of the β+/EC decay of the very neutron-deficient and alpha-unbound nucleus 115Cs is presented. The measurement was performed at the ISOLDE, CERN where delayed charged particles and γ rays were detected. The observed delayed γ rays are in agreement with the previously reported characteristics γ rays of 115Xe. Based on the experimental observations, the tentative ground-state spin
We study recurrence in the real quadratic family and give a sufficient condition on the recurrence rate of the critical orbit such that, for almost every non-regular parameter a, the set of n such that Fn(0;a) is infinite. In particular, when, this extends an earlier result by Avila and Moreira [Statistical properties of unimodal maps: the quadratic family. Ann. of Math. (2) 161(2) (2005), 831-881
Purpose: To examine risks of attention-deficit/hyperactivity disorder (ADHD) in preterm and early term birth survivors, and potential sex-specific differences. Methods: A national cohort study was conducted of all 4061,795 singletons born in Sweden in 1973–2013 who survived infancy, followed up for ADHD identified from nationwide diagnoses and medications through 2018. Poisson regression was used
Objective: The number of type-II endometrial cancer patients has been increasing and the prognosis is not favorable. We aim to investigate whether sarcopenia index in any of several different muscles could serve as a novel biomarker of prognosis in patients with type-II endometrial cancer. Methods: We retrospectively investigated a total of 194 patients at four hospitals. Ninety patients were trea
The advent of 6G wireless communication marks a transformative era in technological connectivity, bringing forth challenges and opportunities alike. This paper unveils an innovative, open-source simulator, meticulously crafted for cell-free 6G wireless networks. This simulator is not just a tool but a gateway to the future, blending cutting-edge channel models with the simulation of both physical
This paper treats the problem of feedforward control from measurable load disturbances. Most of the tuning rules based on IAE or ISE optimization for feedforward compensators that have been presented in recent years are compared with each other as well as with optimal compensators. There are two different feedforward control schemes that may be used, and these schemes are also compared and analyze
This work presents a multivariable control strategy to regulate nighttime temperature and relative humidity inside a greenhouse, using a pipe heating system and a dehumidification system. The greenhouse is modeled as a two-input two-output (TITO) process with a system identification methodology to calculate low-order linear models. Proportional-integral (PI) controllers with anti-windup are used,
