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Differential expression of the inflammatory ciita gene may be accompanied by altered bone properties in intact sex steroid-deficient female rats

Objective: The class II transactivator (CIITA), encoded by the CIITA gene, controls expression of immune response regulators, which affect bone homeostasis. Previously, we investigated a functional CIITA polymorphism in elderly women. Women carrying the allele associated with lower CIITA levels displayed higher bone mineral density (BMD), but also higher bone loss. The present exploratory study in

Human-Material Relationships around 4000 BCE : Continuity and Change in South Scandinavian Flint Tool Production Technologies

Recent studies have found that explanations of the neolithisation of South Scandinavia based on dichotomies between migration (population replacement) and diffusion (in-group change) are insufficient if we want to understand the complexity and variation involved in what happened during the centuries around 4000 BCE. However, these contrasting narratives still overshadow discussions on change in So

Relations, territories, and politics of infrastructural regionalism

In this afterword to the special issue on ‘Water, Governance, and the Dynamics of Infrastructural Regionalism’, I reflect on three achievements of regional infrastructures that are common to all the articles. First, I discuss the relational ontologies and epistemologies that the authors use to characterise the multifaceted connections between humans and non-humans, as well as the imaginaries that

Estimating Respiratory Modulation in Atrial Fibrillation Using a Convolutional Neural Network

The quantification of autonomic nervous system (ANS) activity from ECG data may provide useful information for personalizing atrial fibrillation (AF) treatment, but is currently not possible. Since respiration is known to elicit an ANS response, the purpose of this study was to assess whether the respiratory modulation in AV nodal refractory period and conduction delay during AF can be estimated f

Pollinator-mediated effects of landscape-scale land use on grassland plant community composition and ecosystem functioning – seven hypotheses

Environmental change is disrupting mutualisms between organisms worldwide. Reported declines in insect populations and changes in pollinator community compositions in response to land use and other environmental drivers have put the spotlight on the need to conserve pollinators. While this is often motivated by their role in supporting crop yields, the role of pollinators for reproduction and resu

Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity

INTRODUCTION: Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential. METHODS: We examined Gal-3 levels in brain, serum, and cerebrospinal flu

Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort

Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early life. We studied a population of 977,637 singleton women born in in Sweden between 1973 and 1995, follo

Artificial intelligence for improving public transport : A mapping study

The objective of this study is to provide a better understanding of the potential of using Artificial Intelligence (AI) to improve Public Transport (PT), by reviewing research literature. The selection process resulted in 87 scientific publications constituting a sample of how AI has been applied to improve PT. The review shows that the primary aims of using AI are to improve the service quality o

Extremely low daylight sea-crossing flights of a nocturnal migrant

Understanding the trade-off between energy expenditure of carrying large fuel loads and the risk of fuel depletion is imperative to understand the evolution of flight strategies during long-distance animal migration. Global flyways regularly involve sea crossings that may impose flight prolongations on migrating land-birds and thereby reduce their energy reserves and survival prospects. We studied

Context Effects on Duration, Fundamental Frequency, and Intonation in Human-directed Domestic Cat Meows

In this study, we investigated the prosody of domestic cat meows produced in different contexts. Prosodic cues – i.e., variation in intonation, duration, voice quality and fundamental frequency – in humans as well as in nonhuman animals carry information about idiosyncratic traits of the signaller, including sex, age, and physical and mental state. The duration, fundamental frequency (F0) and into

Exploration of sensations evoked during electrical stimulation of the median nerve at the wrist level

Objective. Nerve rehabilitation following nerve injury or surgery at the wrist level is a lengthy process during which not only peripheral nerves regrow towards receptors and muscles, but also the brain undergoes plastic changes. As a result, at the time when nerves reach their targets, the brain might have already allocated some of the areas within the somatosensory cortex that originally process

Diminishing returns of growth? Economic performance, needs satisfaction and ecological impacts of OECD welfare states

The environmental crisis, increased inequality and an aging population are likely to increase the demand for welfare services in the OECD countries. Economic growth has long been seen as a solution to these problems. However, this is no longer the case. Very few countries have managed to decouple economic performance from ecological footprints and greenhouse gas emissions. Even where this has been

Interplay between flavor anomalies and neutrino properties

A minimal extension of the Standard Model (SM) featuring two scalar leptoquarks, an SU(2) doublet with hypercharge 1/6 and a singlet with hypercharge 1/3, is proposed as an economical benchmark model for studies of an interplay between flavor physics and properties of the neutrino sector. The presence of such type of leptoquarks radiatively generates neutrino masses and offers a simultaneous expla

A Novel Predictor for the Analysis and Prediction of Enhancers and Their Strength via Multi-View Features and Deep Forest

Enhancers are short DNA segments (50–1500 bp) that effectively activate gene transcription when transcription factors (TFs) are present. There is a correlation between the genetic differences in enhancers and numerous human disorders including cancer and inflammatory bowel disease. In computational biology, the accurate categorization of enhancers can yield important information for drug discovery

Clarifying and strengthening the role of law and governance in climate scenario frameworks

Shared socio-economic pathways (SSPs) and shared policy assumptions (SPAs) are lauded as a common basis for climate scenario research across disciplines, yet they lack essential legal and governance elements that are indispensable when assessing future development pathways. This article sets out to address this shortcoming by explaining the interrelated but distinct features of law and governance

Coexistence of s -wave superconductivity and phase separation in the half-filled extended Hubbard model with attractive interactions

Understanding competing instabilities in systems with correlated fermions remains one of the holy grails of modern condensed matter physics. Among the fermionic lattice models used to this effect, the extended Hubbard model occupies a prime place due to the potential relevance of its repulsive and attractive versions for both electronic materials and artificial systems. Using the recently introduc